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Product Details
PA5-53066
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PREB. Recombinant protein control fragment (Product #RP-90969).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2645927
Product Specific Information
Immunogen sequence: REAHGIVVTD VAFLPEKGRG PELLGSHETA LFSVAVDSRC QLHLLPSRRS VP
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
Target Information
Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins. A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Guanine nucleotide-exchange factor SEC12; mammalian guanine nucleotide exchange factor mSec12; Mammalian guanine nucleotide exchange factor Sec12; mSec12; prolactin regulatory binding-element protein; Prolactin regulatory element-binding protein
Gene Aliases: C85705; PREB; SEC12
UniProt ID: (Human) Q9HCU5, (Rat) Q6AYS1, (Mouse) Q9WUQ2
Entrez Gene ID: (Human) 10113, (Rat) 58842, (Mouse) 50907
transcription, DNA-templated
regulation of transcription, DNA-templated
ER to Golgi vesicle-mediated transport
protein exit from endoplasmic reticulum
IRE1-mediated unfolded protein response
positive regulation of GTPase activity
COPII vesicle coating
protein transport
vesicle-mediated transport
positive regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transport
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