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Abnova
PRICKLE1 Monoclonal Antibody (8G5)
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Product Details
H00144165-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
8G5
Immunogen
PRICKLE1 (NP_694571, 684 a.a. approximately 756 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: DNALNLVTER KYSPKDRLRL YTPDNYEKFI QNKSAREIQA YIQNADLYGQ YAHATPDYGL QNPGMNRFLG LYG
Target Information
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: prickle homolog 1; prickle-like 1; Prickle-like protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; REST/NRSF interacting LIM domain protein; REST/NRSF-interacting LIM domain protein 1
Gene Aliases: EPM1B; PRICKLE1; RILP
UniProt ID: (Human) Q96MT3
Entrez Gene ID: (Human) 144165
neural tube closure
protein import into nucleus
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
aorta development
negative regulation of transcription, DNA-templated
Wnt signaling pathway, planar cell polarity pathway
coronary vasculature development
negative regulation of canonical Wnt signaling pathway
negative regulation of cardiac muscle cell myoblast differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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