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Product Details
H00051422-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3C4
Immunogen
PRKAG2 (AAH20540, 191 a.a. approximately 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: AFMKQNLDEL GIGTYHNIAF IHPDTPIIKA LNIFVERRIS ALPVVDESGK VVDIYSKFDV INLAAEKTYN NLDITVTQAL QHRSQYFEGV VKCNKLEILE TIVDRIVRAE
Target Information
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-AMP-activated protein kinase subunit gamma-2; ampk gamma; AMPK gamma2; AMPK subunit gamma-2; H91620p; OTTHUMP00000211956; protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Gene Aliases: AAKG; AAKG2; CMH6; H91620p; PRKAG2; WPWS
UniProt ID: (Human) Q9UGJ0
Entrez Gene ID: (Human) 51422
glycogen metabolic process
regulation of glycolytic process
protein phosphorylation
negative regulation of protein kinase activity
fatty acid biosynthetic process
ATP biosynthetic process
carnitine shuttle
cell cycle arrest
positive regulation of peptidyl-threonine phosphorylation
sterol biosynthetic process
macroautophagy
regulation of fatty acid metabolic process
activation of protein kinase activity
intracellular signal transduction
regulation of fatty acid biosynthetic process
positive regulation of protein kinase activity
regulation of fatty acid oxidation
regulation of glucose import
negative regulation of protein serine/threonine kinase activity
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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