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Abnova
PRKCABP Monoclonal Antibody (3G5)
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Product Details
H00009463-M01
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3G5
Immunogen
PRKCABP (NP_036539, 266 a.a. approximately 375 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Tissue lysate).
Immunogen sequence: KVKEMDDEEY SCIALGEPLY RVSTGNYEYR LILRCRQEAR ARFSQMRKDV LEKMELLDQK HVQDIVFQLQ RLVSTMSKYY NDCYAVLRDA DVFPIEVDLA HTTLAYGLNQ
Target Information
PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC15204; OTTHUMP00000028509; PRKCA-binding protein; Protein interacting with C kinase 1; protein kinase C, alpha binding protein; Protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
Gene Aliases: PICK; PICK1; PRKCABP
UniProt ID: (Human) Q9NRD5, (Rat) Q9EP80
Entrez Gene ID: (Human) 9463, (Rat) 84591
G-protein coupled receptor binding
protein kinase C binding
receptor binding
protein binding
protein C-terminus binding
ATPase activity
enzyme binding
protein domain specific binding
identical protein binding
metal ion binding
actin filament binding
Arp2/3 complex binding
kinase activity
receptor tyrosine kinase binding
G-protein coupled glutamate receptor binding
ephrin receptor binding
GTPase binding
positive regulation of receptor internalization
protein phosphorylation
protein targeting
protein kinase C-activating G-protein coupled receptor signaling pathway
negative regulation of gene expression
monoamine transport
dopamine transport
phosphorylation
glial cell development
negative regulation of Arp2/3 complex-mediated actin nucleation
cellular response to decreased oxygen levels
cellular response to glucose starvation
receptor clustering
long term synaptic depression
negative regulation of cell death
dendritic spine organization
dendritic spine maintenance
retrograde vesicle-mediated transport, Golgi to ER
regulation of Arp2/3 complex-mediated actin nucleation
DNA methylation involved in embryo development
DNA methylation involved in gamete generation
neuronal ion channel clustering
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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