Proteintech

PRKCDBP Polyclonal Antibody

PRKCDBP Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

PRKCDBP Antibody (16250-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using PRKCDBP antibody 16250-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

PRKCDBP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PRKCDBP Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16250-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PRKCDBP Fusion Protein Ag9209 (1-261 aa encoded by BC011585)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRESALEPG PVPEAPAGGP VHAVTVVTLL EKLASMLETL RERQGGLARR QGGLAGSVRR IQSGLGALSR SHDTTSNTLA QLLAKAERVS SHANAAQERA VRRAAQVQRL EANHGLLVAR GKLHVLLFKE EGEVPASAFQ KAPEPLGPAD QSELGPEQLE AEVGESSDEE PVESRAQRLR RTGLQKVQSL RRALSGRKGP AAPPPTPVKP PRLGPGRSAE AQPEAQPALE PTLEPEPPQD TEEDPGRPGA AEEALLQMES VA (1-261 aa encoded by BC011585)

Target Information

JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.

Animal science journal = Nihon chikusan Gakkaiho

Shi M,Yang S,Huang X,Wang S,Li W,Yun J,Lu C,Yang Y,Cai C,Gao P,Guo X,Li B,Cao G

Mon Mar 20 00:00:00 UTC 2023

Caveolae-associated protein 3 promotes adipogenic differentiation of porcine preadipocytes by promoting extracellular signal-regulated kinase phosphorylation.

Animal science journal = Nihon chikusan Gakkaiho

Shi M,Yang S,Huang X,Wang S,Li W,Yun J,Lu C,Yang Y,Cai C,Gao P,Guo X,Li B,Cao G

Mon Mar 20 00:00:00 UTC 2023

The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS-14036/miR-1228-5p/PRKCDBP pathway.

Cell proliferation

Jiang R,Lu B,Feng F,Li Q,Chen X,Cao S,Pan Z,Deng Z,Zhou Y,Liu P,Xu J

Sat Jul 01 00:00:00 UTC 2023

The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS-14036/miR-1228-5p/PRKCDBP pathway.

Cell proliferation

Jiang R,Lu B,Feng F,Li Q,Chen X,Cao S,Pan Z,Deng Z,Zhou Y,Liu P,Xu J

Sat Jul 01 00:00:00 UTC 2023

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2.

Developmental cell

Wu Y,Lim YW,Stroud DA,Martel N,Hall TE,Lo HP,Ferguson C,Ryan MT,McMahon KA,Parton RG

Mon Mar 13 00:00:00 UTC 2023

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2.

Developmental cell

Wu Y,Lim YW,Stroud DA,Martel N,Hall TE,Lo HP,Ferguson C,Ryan MT,McMahon KA,Parton RG

Mon Mar 13 00:00:00 UTC 2023

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2.

Developmental cell

Wu Y,Lim YW,Stroud DA,Martel N,Hall TE,Lo HP,Ferguson C,Ryan MT,McMahon KA,Parton RG

Mon Mar 13 00:00:00 UTC 2023

Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation.

Molecular metabolism

Higuchi Y,Ogata T,Nakanishi N,Nishi M,Sakamoto A,Tsuji Y,Tomita S,Matoba S

Sat Jan 01 00:00:00 UTC 2022

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.

eLife

McMahon KA,Stroud DA,Gambin Y,Tillu V,Bastiani M,Sierecki E,Polinkovsky ME,Hall TE,Gomez GA,Wu Y,Parat MO,Martel N,Lo HP,Khanna KK,Alexandrov K,Daly R,Yap A,Ryan MT,Parton RG

Fri Jun 18 00:00:00 UTC 2021

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.

eLife

McMahon KA,Stroud DA,Gambin Y,Tillu V,Bastiani M,Sierecki E,Polinkovsky ME,Hall TE,Gomez GA,Wu Y,Parat MO,Martel N,Lo HP,Khanna KK,Alexandrov K,Daly R,Yap A,Ryan MT,Parton RG

Fri Jun 18 00:00:00 UTC 2021

Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.

ACS nano

Liao Z,Liu H,Ma L,Lei J,Tong B,Li G,Ke W,Wang K,Feng X,Hua W,Li S,Yang C

Tue Sep 28 00:00:00 UTC 2021

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.

Nature communications

McMahon KA,Wu Y,Gambin Y,Sierecki E,Tillu VA,Hall T,Martel N,Okano S,Moradi SV,Ruelcke JE,Ferguson C,Yap AS,Alexandrov K,Hill MM,Parton RG

Mon Jul 22 00:00:00 UTC 2019

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.

Nature communications

McMahon KA,Wu Y,Gambin Y,Sierecki E,Tillu VA,Hall T,Martel N,Okano S,Moradi SV,Ruelcke JE,Ferguson C,Yap AS,Alexandrov K,Hill MM,Parton RG

Mon Jul 22 00:00:00 UTC 2019

Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle.

Cell and tissue research

Zhu B,Swärd K,Ekman M,Uvelius B,Rippe C

Thu Jun 01 00:00:00 UTC 2017

Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle.

Cell and tissue research

Zhu B,Swärd K,Ekman M,Uvelius B,Rippe C

Thu Jun 01 00:00:00 UTC 2017

PloS one

Zhu B,Rippe C,Thi Hien T,Zeng J,Albinsson S,Stenkula KG,Uvelius B,Swärd K

Mon Sep 11 00:00:00 UTC 2017

PloS one

Zhu B,Rippe C,Thi Hien T,Zeng J,Albinsson S,Stenkula KG,Uvelius B,Swärd K

Mon Sep 11 00:00:00 UTC 2017

Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination.

eLife

Seemann E,Sun M,Krueger S,Tröger J,Hou W,Haag N,Schüler S,Westermann M,Huebner CA,Romeike B,Kessels MM,Qualmann B

Tue Dec 05 00:00:00 UTC 2017

Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination.

eLife

Seemann E,Sun M,Krueger S,Tröger J,Hou W,Haag N,Schüler S,Westermann M,Huebner CA,Romeike B,Kessels MM,Qualmann B

Tue Dec 05 00:00:00 UTC 2017

Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1.

BMC nephrology

Krawczyk KM,Hansson J,Nilsson H,Krawczyk KK,Swärd K,Johansson ME

Tue Oct 24 00:00:00 UTC 2017

Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1.

BMC nephrology

Krawczyk KM,Hansson J,Nilsson H,Krawczyk KK,Swärd K,Johansson ME

Tue Oct 24 00:00:00 UTC 2017

Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1.

BMC nephrology

Krawczyk KM,Hansson J,Nilsson H,Krawczyk KK,Swärd K,Johansson ME

Tue Oct 24 00:00:00 UTC 2017

Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1.

BMC nephrology

Krawczyk KM,Hansson J,Nilsson H,Krawczyk KK,Swärd K,Johansson ME

Tue Oct 24 00:00:00 UTC 2017

Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner.

PloS one

Hansson B,Rippe C,Kotowska D,Wasserstrom S,Säll J,Göransson O,Swärd K,Stenkula KG

Thu Aug 31 00:00:00 UTC 2017

Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner.

PloS one

Hansson B,Rippe C,Kotowska D,Wasserstrom S,Säll J,Göransson O,Swärd K,Stenkula KG

Thu Aug 31 00:00:00 UTC 2017

P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Tome ME,Herndon JM,Schaefer CP,Jacobs LM,Zhang Y,Jarvis CK,Davis TP

Tue Nov 01 00:00:00 UTC 2016

P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Tome ME,Herndon JM,Schaefer CP,Jacobs LM,Zhang Y,Jarvis CK,Davis TP

Tue Nov 01 00:00:00 UTC 2016

PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis.

PloS one

Taniguchi T,Maruyama N,Ogata T,Kasahara T,Nakanishi N,Miyagawa K,Naito D,Hamaoka T,Nishi M,Matoba S,Ueyama T

Mon Aug 28 00:00:00 UTC 2017

PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis.

PloS one

Taniguchi T,Maruyama N,Ogata T,Kasahara T,Nakanishi N,Miyagawa K,Naito D,Hamaoka T,Nishi M,Matoba S,Ueyama T

Mon Aug 28 00:00:00 UTC 2017

Vasopressin-induced mouse urethral contraction is modulated by caveolin-1.

European journal of pharmacology

Zeng J,Ekman M,Grossi M,Svensson D,Nilsson BO,Jiang C,Uvelius B,Swärd K

Thu Mar 05 00:00:00 UTC 2015

Vasopressin-induced mouse urethral contraction is modulated by caveolin-1.

European journal of pharmacology

Zeng J,Ekman M,Grossi M,Svensson D,Nilsson BO,Jiang C,Uvelius B,Swärd K

Thu Mar 05 00:00:00 UTC 2015

Myocardin Family Members Drive Formation of Caveolae.

PloS one

Krawczyk KK,Yao Mattisson I,Ekman M,Oskolkov N,Grantinge R,Kotowska D,Olde B,Hansson O,Albinsson S,Miano JM,Rippe C,Swärd K

Tue May 17 00:00:00 UTC 2016

Myocardin Family Members Drive Formation of Caveolae.

PloS one

Krawczyk KK,Yao Mattisson I,Ekman M,Oskolkov N,Grantinge R,Kotowska D,Olde B,Hansson O,Albinsson S,Miano JM,Rippe C,Swärd K

Tue May 17 00:00:00 UTC 2016

Endocytic crosstalk: cavins, caveolins, and caveolae regulate clathrin-independent endocytosis.

PLoS biology

Chaudhary N,Gomez GA,Howes MT,Lo HP,McMahon KA,Rae JA,Schieber NL,Hill MM,Gaus K,Yap AS,Parton RG

Tue Apr 01 00:00:00 UTC 2014

Endocytic crosstalk: cavins, caveolins, and caveolae regulate clathrin-independent endocytosis.

PLoS biology

Chaudhary N,Gomez GA,Howes MT,Lo HP,McMahon KA,Rae JA,Schieber NL,Hill MM,Gaus K,Yap AS,Parton RG

Tue Apr 01 00:00:00 UTC 2014

Elevation of PRKCDBP, a novel transcriptional target of TNF-α, and its downregulation by infliximab in patients with ulcerative colitis.

Digestive diseases and sciences

Kim JW,Kim HJ,Lee CK,Shim JJ,Jang JY,Dong SH,Kim BH,Chang YW,Chi SG

Mon Dec 01 00:00:00 UTC 2014

Elevation of PRKCDBP, a novel transcriptional target of TNF-α, and its downregulation by infliximab in patients with ulcerative colitis.

Digestive diseases and sciences

Kim JW,Kim HJ,Lee CK,Shim JJ,Jang JY,Dong SH,Kim BH,Chang YW,Chi SG

Mon Dec 01 00:00:00 UTC 2014

Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.

PloS one

Swärd K,Albinsson S,Rippe C

Tue Jan 20 00:00:00 UTC 2015

Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.

PloS one

Swärd K,Albinsson S,Rippe C

Tue Jan 20 00:00:00 UTC 2015

Cavin-3 dictates the balance between ERK and Akt signaling.

eLife

Hernandez VJ,Weng J,Ly P,Pompey S,Dong H,Mishra L,Schwarz M,Anderson RG,Michaely P

Tue Sep 24 00:00:00 UTC 2013

Cavin-3 dictates the balance between ERK and Akt signaling.

eLife

Hernandez VJ,Weng J,Ly P,Pompey S,Dong H,Mishra L,Schwarz M,Anderson RG,Michaely P

Tue Sep 24 00:00:00 UTC 2013

Cavin-3 dictates the balance between ERK and Akt signaling.

eLife

Hernandez VJ,Weng J,Ly P,Pompey S,Dong H,Mishra L,Schwarz M,Anderson RG,Michaely P

Tue Sep 24 00:00:00 UTC 2013

Cavin-3 dictates the balance between ERK and Akt signaling.

eLife

Hernandez VJ,Weng J,Ly P,Pompey S,Dong H,Mishra L,Schwarz M,Anderson RG,Michaely P

Tue Sep 24 00:00:00 UTC 2013

Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.

Physiological reports

Swärd K,Sadegh MK,Mori M,Erjefält JS,Rippe C

Sat Jun 01 00:00:00 UTC 2013

Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.

Physiological reports

Swärd K,Sadegh MK,Mori M,Erjefält JS,Rippe C

Sat Jun 01 00:00:00 UTC 2013

Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice.

European journal of pharmacology

Karbalaei MS,Rippe C,Albinsson S,Ekman M,Mansten A,Uvelius B,Swärd K

Wed Aug 15 00:00:00 UTC 2012

Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice.

European journal of pharmacology

Karbalaei MS,Rippe C,Albinsson S,Ekman M,Mansten A,Uvelius B,Swärd K

Wed Aug 15 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: Caveolae-associated protein 3; cavin 3; Cavin-3; D3T-inducible gene 2 protein; DIG-2; Dithiolethione-inducible gene 2 protein; dithiolethione-inducible gene-2; hSRBC; MGC20400; PKC-delta binding protein; Protein kinase C delta-binding protein; protein kinase C, delta binding protein; sdr-elated gene product that binds to c-kinase; sdr-related gene product that binds to c-kinase; Serum deprivation response factor-related gene product that binds to C-kinase

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Gene Aliases: 3110015B12Rik; 6330514M23Rik; cavin-3; CAVIN3; DIG-2; Dig2; HSRBC; PRKCDBP; SRBC

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UniProt ID: (Human) Q969G5, (Mouse) Q91VJ2, (Rat) Q9Z1H9

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Entrez Gene ID: (Human) 112464, (Mouse) 109042, (Rat) 85332

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Function(s)

protein kinase C binding protein binding

Process(es)

cortical actin cytoskeleton organization circadian regulation of gene expression rhythmic process negative regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade negative regulation of fermentation regulation of cell growth

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PRKCDBP Polyclonal Antibody

PRKCDBP Antibody (16250-1-AP) in ICC/IF

Product Details

16250-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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