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Invitrogen
PRL1 Polyclonal Antibody
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FIGURE: 1 / 3
PRL1 Antibody (PA5-67528) in ICC/IF
Immunofluorescence analysis of PRL1 in NIH3T3 cells fixed with 4% PFA, permeabilized with 0.2% Triton X-100 and stained with polyclonal PRL1 antibody (Product # PA5-67528) at 1:40. Cells were co-stained with DAPI (blue). Data courtesy of Dr. Xiaofang Tang at Cincinnati Children's Hospital Medical Center.
Product Details
PA5-67528
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein of human PRL1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2688527
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp779M0721; PRL-1; protein tyrosine phosphatase 4a1; Protein tyrosine phosphatase type IVA 1; protein tyrosine phosphatase type IVA protein 1; Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PTP(CAAXI); PTP4A1 protein; PTP4A2; RP5-1148A21.2
Gene Aliases: AA415290; AU019864; C130021B01; HH72; PRL-1; PRL1; PTP(CAAX1); PTP4A1; PTPCAAX1
UniProt ID: (Human) Q93096, (Rat) Q78EG7, (Mouse) Q63739
Entrez Gene ID: (Human) 7803, (Rat) 29463, (Mouse) 19243
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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