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Invitrogen
PRMT2 Polyclonal Antibody
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Product Details
PA5-142908
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-DQPRTTKYHSVILQ.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933551
Product Specific Information
Additional Information: This antibody is expected to recognize all reported isoforms (NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone-arginine N-methyltransferase PRMT2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1; HMT1 hnRNP methyltransferase-like 1; MGC111373; PRMT2 alpha; PRMT2 beta; PRMT2 gamma; Protein arginine N-methyltransferase 2
Gene Aliases: AI504737; HMT1; HRMT1L1; PRMT2
UniProt ID: (Human) P55345
Entrez Gene ID: (Human) 3275, (Mouse) 15468, (Rat) 499420
transcription coactivator activity
signal transducer activity
protein binding
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
estrogen receptor binding
progesterone receptor binding
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
protein homodimerization activity
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
thyroid hormone receptor binding
androgen receptor binding
molecular_function
cytokine activity
tumor necrosis factor receptor binding
beta-catenin binding
protein methylation
signal transduction
histone methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
negative regulation of NF-kappaB transcription factor activity
histone arginine methylation
positive regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
developmental cell growth
regulation of androgen receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
response to hypoxia
immune response
biological_process
peptidyl-arginine N-methylation
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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