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OriGene
PRMT5 Monoclonal Antibody (OTI2H3), TrueMAB™
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Product Details
CF807621
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI2H3
Immunogen
Human recombinant protein fragment corresponding to amino acids 238-499 of human PRMT5 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
PRMT5 (protein arginine N-methyltransferase 5) is an arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. PRMT5 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3; such methylation is required for the assembly and biogenesis of snRNP core particles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 72 kDa ICln-binding protein; EC 2.1.1.125; Histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase-like 5; Jak-binding protein 1; PRMT5; Protein arginine N-methyltransferase 5; Shk1 kinase-binding protein 1 homolog; SKB1 homolog
Gene Aliases: HRMT1L5; IBP72; JBP1; PRMT5; SKB1; SKB1Hs
UniProt ID: (Human) O14744
Entrez Gene ID: (Human) 10419
core promoter sequence-specific DNA binding
transcription corepressor activity
protein binding
methyltransferase activity
methyl-CpG binding
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
protein complex binding
protein-arginine omega-N symmetric methyltransferase activity
ribonucleoprotein complex binding
histone methyltransferase activity (H4-R3 specific)
protein heterodimerization activity
spliceosomal snRNP assembly
DNA-templated transcription, termination
regulation of transcription, DNA-templated
regulation of mitotic nuclear division
cell proliferation
peptidyl-arginine methylation
peptidyl-arginine methylation, to symmetrical-dimethyl arginine
circadian regulation of gene expression
peptidyl-arginine N-methylation
endothelial cell activation
histone H4-R3 methylation
regulation of DNA methylation
negative regulation of cell differentiation
positive regulation of oligodendrocyte differentiation
regulation of ERK1 and ERK2 cascade
Golgi ribbon formation
liver regeneration
regulation of signal transduction by p53 class mediator
negative regulation of nucleic acid-templated transcription
positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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