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Product Details
BS-5784R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PROK2/Prokineticin 2, amino acids 28-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the suprachiasmatic nucleus (SCN) with receptors located in the critical autonomic control centers of the brain. It has a depolarizing effect on neurons expressing the receptor. PK2 is predominantly controlled by the endogenous circadian clock, but light also plays a modulatory role. PK2 functions as a critical SCN output molecule responsible for circadian locomotor rhythms. PK2 expression is high during the day, and responsive to nocturnal light pulses. PK2 also functions as a chemoattractant for subventricular zone-derived neuronal progenitors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bombina variegata 8 kD protein; Bombina variegata 8kDa protein; Bv 8 homolog (Bombina variegata); homolog of mouse Bv8 (Bombina variegata 8 kDa); homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2; PK2; prokineticin 1; prokineticin 2 beta; Prokineticin-2; Protein Bv8 homolog
Gene Aliases: BV8; HH4; KAL4; MIT1; PK2; Prok1; PROK2
UniProt ID: (Human) Q9HC23, (Rat) Q8R413, (Mouse) Q9QXU7
Entrez Gene ID: (Human) 60675, (Rat) 192206, (Mouse) 50501
activation of MAPK activity
angiogenesis
chemotaxis
inflammatory response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
spermatogenesis
circadian rhythm
cell proliferation
positive regulation of cell proliferation
sensory perception of pain
negative regulation of apoptotic process
regulation of angiogenesis
positive regulation of smooth muscle contraction
rhythmic process
epicardium-derived cardiac endothelial cell differentiation
coronary vasculature development
vasculogenesis involved in coronary vascular morphogenesis
epicardium-derived cardiac vascular smooth muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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