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Invitrogen
PRPF39 Polyclonal Antibody
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Product Details
PA5-51528
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PRPF39. Recombinant protein control fragment (Product #RP-89011).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2645971
Product Specific Information
Immunogen sequence: DINWENEQGN LREVTAIYDR ILGIPTQLYS HHFQRFKEHV QNNLPRDLLT GEQFIQLRRE LASVNGHSGD DGPPGDDLPS GIEDITDPAK LITEIENMRH RIIEIHQEMF NYNEHEVSKR WTFEEGIKRP YFHVKPLEKA QL
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 98%.
Target Information
The PRPF39 gene plays a critical role as a splicing factor involved in alternative splicing regulation. In humans, it is homologous to the yeast Prp39 and Prp42 paralogs, forming a homodimer that interacts with the carboxy-terminal domain (CTD) of U1C, a parallel mechanism observed in the yeast Prp39/Prp42 heterodimer. Recent studies have highlighted its impact on splicing efficiency through knockdown experiments in HEK293 cells, which revealed significant changes in the expression of many genes, underscoring its importance in splicing adaptability according to cell type-specific needs. Additionally, PRPF39 is found to be highly expressed in Acute Lymphoblastic Leukemia (ALL), with research suggesting that targeting PRPF39 for degradation could contribute to the treatment of ALL. Phylogenetic analyses indicate a coevolution of PRPF39 expression with molecular components like shortened U1 snRNA, reflecting the splicing complexity across different species. The gene is also involved in the regulation of distant genes which are relevant to cellular responses, such as those involved in cisplatin response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: flj11128; flj20666; flj45460; mgc149842; mgc149843; Pre-mRNA-processing factor 39; PRP39 homolog; PRP39 pre-mRNA processing factor 39 homolog; v-src suppressed transcript 1
Gene Aliases: PRPF39; Srcs1
UniProt ID: (Human) Q86UA1
Entrez Gene ID: (Human) 55015, (Rat) 314171, (Mouse) 328110
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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