Proteintech

PRPH2 Polyclonal Antibody

PRPH2 Antibody in Immunohistochemistry (IHC)

FIGURE: 1 / 3

PRPH2 Antibody (18109-1-AP) in IHC

IF result of anti-PRPH2 (18109-1-AP) in Mouse Retina by Dr. Seongjin Seo. OS (Outer segment) Stain.

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Product Details

18109-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

Assay-dependent

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

1:20-1:200

View 7 publications 7 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PRPH2 Fusion Protein Ag12555 (124-346 aa encoded by BC074720)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GSLENTLGQ GLKNGMKYYR DTDTPGRCFM KKTIDMLQIE FKCCGNNGFR DWFEIQWISN RYLDFSSKEV KDRIKSNVDG RYLVDGVPFS CCNPSSPRPC IQYQITNNSA HYSYDHQTEE LNLWVRGCRA ALLSYYSSLM NSMGVVTLLI WLFEVTITIG LRYLQTSLDG VSNPEESESE SEGWLLEKSV PETWKAFLES VKKLGKGNQV EAEGAGAGQA PEAG (124-346 aa encoded by B C074720)

Target Information

Peripherin-2 (PRPH2), also known as retinal degeneration slow protein (RDS), is a photoreceptor-specific tetraspanin protein implicated in outer segment disk morphogenesis. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Mutations in peripherin-2 are responsible for various retinal degenerative diseases including autosomal dominant retinitis pigmentosa (ADRP).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Deletion of Emc1 in photoreceptor cells causes retinal degeneration in mice.

The FEBS journal

Li X,Jiang Z,Su Y,Wang K,Jiang X,Sun K,Yang Y,Zhou Y,Zhu X,Zhang L

Fri Sep 01 00:00:00 UTC 2023

Deletion of Emc1 in photoreceptor cells causes retinal degeneration in mice.

The FEBS journal

Li X,Jiang Z,Su Y,Wang K,Jiang X,Sun K,Yang Y,Zhou Y,Zhu X,Zhang L

Fri Sep 01 00:00:00 UTC 2023

Subretinal gene therapy delays vision loss in a Bardet-Biedl Syndrome type 10 mouse model.

Molecular therapy. Nucleic acids

Hsu Y,Bhattarai S,Thompson JM,Mahoney A,Thomas J,Mayer SK,Datta P,Garrison J,Searby CC,Vandenberghe LH,Seo S,Sheffield VC,Drack AV

Tue Mar 14 00:00:00 UTC 2023

A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation.

iScience

Yamasaki S,Tu HY,Matsuyama T,Horiuchi M,Hashiguchi T,Sho J,Kuwahara A,Kishino A,Kimura T,Takahashi M,Mandai M

Fri Jan 21 00:00:00 UTC 2022

Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.

PloS one

Datta P,Cribbs JT,Seo S

Wed Jul 24 00:00:00 UTC 2024

Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.

PloS one

Datta P,Cribbs JT,Seo S

Wed Jul 24 00:00:00 UTC 2024

Multimeric conformation of type III intermediate filaments but not the filamentous conformation exhibits high affinity to lipid bilayers.

Genes to cells : devoted to molecular & cellular mechanisms

Hwang B,Ise H

Mon Jun 01 00:00:00 UTC 2020

Multimeric conformation of type III intermediate filaments but not the filamentous conformation exhibits high affinity to lipid bilayers.

Genes to cells : devoted to molecular & cellular mechanisms

Hwang B,Ise H

Mon Jun 01 00:00:00 UTC 2020

Hydrogel-mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration.

Biomaterials

Mitrousis N,Hacibekiroglu S,Ho MT,Sauvé Y,Nagy A,van der Kooy D,Shoichet MS

Thu Oct 01 00:00:00 UTC 2020

The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors.

The Journal of biological chemistry

Datta P,Hendrickson B,Brendalen S,Ruffcorn A,Seo S

Fri Dec 13 00:00:00 UTC 2019

The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors.

The Journal of biological chemistry

Datta P,Hendrickson B,Brendalen S,Ruffcorn A,Seo S

Fri Dec 13 00:00:00 UTC 2019

The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Otsu W,Hsu YC,Chuang JZ,Sung CH

Wed May 01 00:00:00 UTC 2019

The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Otsu W,Hsu YC,Chuang JZ,Sung CH

Wed May 01 00:00:00 UTC 2019

Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.

Proceedings of the National Academy of Sciences of the United States of America

Shirai H,Mandai M,Matsushita K,Kuwahara A,Yonemura S,Nakano T,Assawachananont J,Kimura T,Saito K,Terasaki H,Eiraku M,Sasai Y,Takahashi M

Tue Jan 05 00:00:00 UTC 2016

Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.

Proceedings of the National Academy of Sciences of the United States of America

Shirai H,Mandai M,Matsushita K,Kuwahara A,Yonemura S,Nakano T,Assawachananont J,Kimura T,Saito K,Terasaki H,Eiraku M,Sasai Y,Takahashi M

Tue Jan 05 00:00:00 UTC 2016

Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function.

Scientific reports

Fujii M,Sunagawa GA,Kondo M,Takahashi M,Mandai M

Tue Aug 02 00:00:00 UTC 2016

Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function.

Scientific reports

Fujii M,Sunagawa GA,Kondo M,Takahashi M,Mandai M

Tue Aug 02 00:00:00 UTC 2016

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 UTC 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 UTC 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 UTC 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 UTC 2015

BBS mutations modify phenotypic expression of CEP290-related ciliopathies.

Human molecular genetics

Zhang Y,Seo S,Bhattarai S,Bugge K,Searby CC,Zhang Q,Drack AV,Stone EM,Sheffield VC

Wed Jan 01 00:00:00 UTC 2014

BBS mutations modify phenotypic expression of CEP290-related ciliopathies.

Human molecular genetics

Zhang Y,Seo S,Bhattarai S,Bugge K,Searby CC,Zhang Q,Drack AV,Stone EM,Sheffield VC

Wed Jan 01 00:00:00 UTC 2014

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.

Proceedings of the National Academy of Sciences of the United States of America

Singh MS,Charbel Issa P,Butler R,Martin C,Lipinski DM,Sekaran S,Barnard AR,MacLaren RE

Tue Jan 15 00:00:00 UTC 2013

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.

Proceedings of the National Academy of Sciences of the United States of America

Singh MS,Charbel Issa P,Butler R,Martin C,Lipinski DM,Sekaran S,Barnard AR,MacLaren RE

Tue Jan 15 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: peripherin 2 (retinal degeneration, slow); peripherin 2, homolog of mouse; peripherin, photoreceptor type; Peripherin-2; retinal degeneration 2; Retinal degeneration slow protein; retinal degeneration, slow; retinal degeneration, slow (retinitis pigmentosa 7); retinal peripherin; Tetraspanin-22; Tspan-22

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Gene Aliases: AOFMD; AVMD; CACD2; DS; MDBS1; Nmf193; PRPH; PRPH2; Rd-2; Rd2; RDS; RP7; RSRDS; TSPAN22

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UniProt ID: (Human) P23942, (Rat) P17438, (Mouse) P15499

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Entrez Gene ID: (Human) 5961, (Rat) 25534, (Mouse) 19133

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Process(es)

cell adhesion cell surface receptor signaling pathway visual perception retina development in camera-type eye response to low light intensity stimulus

Performance Guarantee

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PRPH2 Polyclonal Antibody

PRPH2 Antibody (18109-1-AP) in IHC

Product Details

18109-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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