Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
PRPS2 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
PRPS2 Antibody (PA5-88677) in WB
Western blot analysis of PRPS2 in extracts of various cell lines. Samples were incubated with PRPS2 Polyclonal antibody (Product # PA5-88677) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-88677
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PRPS2 (NP_0027561)
Conjugate
Form
Liquid
Concentration
0.04 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805069
Product Specific Information
Immunogen sequence: MPNIVLFSGS SHQDLSQRVA DRLGLELGKV VTKKFSNQET SVEIGESVRG EDVYIIQSGC GEINDNLMEL LIMINACKIA SSSRVTAVIP CFPYARQDKK DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA VLQWIRENIA EWKNCIIVSP DAGGAKRVTS IADRLNVEFA LIHKERKKAN EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG; Positive Samples: HeLa, MCF-7, Mouse brain, Mouse heart, Mouse kidney, Rat liver
Target Information
The Phosphoribosyl Pyrophosphate Synthetase 2 (PRPS2) gene plays a critical role in cellular metabolism by encoding an enzyme that conducts a key reaction linking central carbon metabolism and nucleotide production, essential for various biological functions. Structurally, PRPS2 shares a high sequence identity with PRPS1, making it less sensitive to allosteric inhibition and particularly significant in certain oncology contexts due to its upregulation at the translational level in some cancers. The enzyme encoded by PRPS2 is pivotal in coupling protein and nucleotide biosynthesis, aided by a unique cis-regulatory element in its 5' UTR, which is influenced by oncogenic pathways. This gene manifests a tissue-specific expression profile, predominantly in proliferative tissues such as the thymus, lung, and small intestine, highlighting its significance in cell growth and proliferation. The evolutionary origins of PRPS2, along with its functional diversification into multiple PRPS genes in eukaryotes, underscore its indispensable role in cellular physiology and pathology.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Phophoribosylpyrophosphate synthetase, subunit II; Phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase II; PPRibP; PPRibP synthetase; PRS-II; ribose-phosphate diphosphokinase 2; Ribose-phosphate pyrophosphokinase 2; testicular secretory protein Li 41
Gene Aliases: 2610101M19Rik; AA589463; AI464149; Prps-2; PRPS2; PRSII
UniProt ID: (Human) P11908, (Rat) P09330, (Mouse) Q9CS42
Entrez Gene ID: (Human) 5634, (Rat) 24689, (Mouse) 110639
5-phosphoribose 1-diphosphate biosynthetic process
AMP biosynthetic process
nucleotide biosynthetic process
phosphorylation
ribose phosphate metabolic process
organ regeneration
nucleobase-containing compound metabolic process
nucleoside metabolic process
ribonucleoside monophosphate biosynthetic process
cellular biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support