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Invitrogen
PRRX1 Polyclonal Antibody
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Product Details
PA5-38008
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
19 amino acid peptide near the center of human PRRX1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2554612
Product Specific Information
A recommended positive control is HeLa cell lysate.
At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein K-2; homeobox protein mHox; Homeobox protein PHOX1; MHox; Muscle homeobox protein; paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; Paired mesoderm homeobox protein 1; Paired-related homeobox protein 1; PRX-1; rHox
Gene Aliases: A230024N07Rik; AA755424; AGOTC; AI385634; AI843499; K-2; mHox; PHOX1; Pmx; PMX1; PRRX1; PRX-1; PRX1
UniProt ID: (Human) P54821, (Mouse) P63013, (Rat) P63014
Entrez Gene ID: (Human) 5396, (Mouse) 18933, (Rat) 266813
negative regulation of transcription from RNA polymerase II promoter
positive regulation of mesenchymal cell proliferation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
embryonic limb morphogenesis
inner ear morphogenesis
middle ear morphogenesis
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
neuron fate determination
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
artery morphogenesis
cartilage development
palate development
regulation of neuron projection regeneration
neuronal stem cell population maintenance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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