Proteintech

PRSS8 Polyclonal Antibody

PRSS8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

PRSS8 Antibody (15527-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse ovary tissue slide using (Product # 15527-1-AP) (PRSS8 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

15527-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PRSS8 Fusion Protein Ag7234 (26-325 aa encoded by BC001462)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize 39 kDa monomer form and 70 kDa homodimer form.

Immunogen sequence: SGTGAEGAE APCGVAPQAR ITGGSSAVAG QWPWQVSITY EGVHVCGGSL VSEQWVLSAA HCFPSEHHKE AYEVKLGAHQ LDSYSEDAKV STLKDIIPHP SYLQEGSQGD IALLQLSRPI TFSRYIRPIC LPAANASFPN GLHCTVTGWG HVAPSVSLLT PKPLQQLEVP LISRETCNCL YNIDAKPEEP HFVQEDMVCA GYVEGGKDAC QGDSGGPLSC PVEGLWYLTG IVSWGDACGA RNRPGVYTLA SSYASWIQSK VTELQPRVVP QTQESQPDSN LCGSHLAFSS APAQGLLRPI L (26-325 aa encoded by BC001462)

Target Information

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sodium retention in nephrotic syndrome is independent of the activation of the membrane-anchored serine protease prostasin (CAP1/PRSS8) and its enzymatic activity.

Pflugers Archiv : European journal of physiology

Essigke D,Bohnert BN,Janessa A,Wörn M,Omage K,Kalbacher H,Birkenfeld AL,Bugge TH,Szabo R,Artunc F

Wed Jun 01 00:00:00 UTC 2022

Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice.

Acta physiologica (Oxford, England)

Essigke D,Ilyaskin AV,Wörn M,Bohnert BN,Xiao M,Daniel C,Amann K,Birkenfeld AL,Szabo R,Bugge TH,Korbmacher C,Artunc F

Sat May 01 00:00:00 UTC 2021

Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice.

Acta physiologica (Oxford, England)

Essigke D,Ilyaskin AV,Wörn M,Bohnert BN,Xiao M,Daniel C,Amann K,Birkenfeld AL,Szabo R,Bugge TH,Korbmacher C,Artunc F

Sat May 01 00:00:00 UTC 2021

Dietary Na⁺ intake in healthy humans changes the urine extracellular vesicle prostasin abundance while the vesicle excretion rate, NCC, and ENaC are not altered.

American journal of physiology. Renal physiology

Zachar R,Jensen BL,Svenningsen P

Sun Dec 01 00:00:00 UTC 2019

Lovastatin attenuates hypertension induced by renal tubule-specific knockout of ATP-binding cassette transporter A1, by inhibiting epithelial sodium channels.

British journal of pharmacology

Wu MM,Liang C,Yu XD,Song BL,Yue Q,Zhai YJ,Linck V,Cai YX,Niu N,Yang X,Zhang BL,Wang QS,Zou L,Zhang S,Thai TL,Ma J,Sutliff RL,Zhang ZR,Ma HP

Sun Sep 01 00:00:00 UTC 2019

The epithelial Na⁺ channel α- and γ-subunits are cleaved at predicted furin-cleavage sites, glycosylated and membrane associated in human kidney.

Pflugers Archiv : European journal of physiology

Zachar R,Mikkelsen MK,Skjødt K,Marcussen N,Zamani R,Jensen BL,Svenningsen P

Sun Dec 01 00:00:00 UTC 2019

Albuminuria in kidney transplant recipients is associated with increased urinary serine proteases and activation of the epithelial sodium channel.

American journal of physiology. Renal physiology

Hinrichs GR,Michelsen JS,Zachar R,Friis UG,Svenningsen P,Birn H,Bistrup C,Jensen BL

Sun Jul 01 00:00:00 UTC 2018

Albuminuria in kidney transplant recipients is associated with increased urinary serine proteases and activation of the epithelial sodium channel.

American journal of physiology. Renal physiology

Hinrichs GR,Michelsen JS,Zachar R,Friis UG,Svenningsen P,Birn H,Bistrup C,Jensen BL

Sun Jul 01 00:00:00 UTC 2018

Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.

Pflugers Archiv : European journal of physiology

Oxlund C,Kurt B,Schwarzensteiner I,Hansen MR,Stæhr M,Svenningsen P,Jacobsen IA,Hansen PB,Thuesen AD,Toft A,Hinrichs GR,Bistrup C,Jensen BL

Thu Jun 01 00:00:00 UTC 2017

Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.

Pflugers Archiv : European journal of physiology

Oxlund C,Kurt B,Schwarzensteiner I,Hansen MR,Stæhr M,Svenningsen P,Jacobsen IA,Hansen PB,Thuesen AD,Toft A,Hinrichs GR,Bistrup C,Jensen BL

Thu Jun 01 00:00:00 UTC 2017

Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.

Pflugers Archiv : European journal of physiology

Oxlund C,Kurt B,Schwarzensteiner I,Hansen MR,Stæhr M,Svenningsen P,Jacobsen IA,Hansen PB,Thuesen AD,Toft A,Hinrichs GR,Bistrup C,Jensen BL

Thu Jun 01 00:00:00 UTC 2017

Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.

Pflugers Archiv : European journal of physiology

Oxlund C,Kurt B,Schwarzensteiner I,Hansen MR,Stæhr M,Svenningsen P,Jacobsen IA,Hansen PB,Thuesen AD,Toft A,Hinrichs GR,Bistrup C,Jensen BL

Thu Jun 01 00:00:00 UTC 2017

Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women.

Journal of hypertension

Frederiksen-Møller B,Jørgensen JS,Hansen MR,Krigslund O,Vogel LK,Andersen LB,Jensen BL

Mon Feb 01 00:00:00 UTC 2016

Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women.

Journal of hypertension

Frederiksen-Møller B,Jørgensen JS,Hansen MR,Krigslund O,Vogel LK,Andersen LB,Jensen BL

Mon Feb 01 00:00:00 UTC 2016

Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women.

Journal of hypertension

Frederiksen-Møller B,Jørgensen JS,Hansen MR,Krigslund O,Vogel LK,Andersen LB,Jensen BL

Mon Feb 01 00:00:00 UTC 2016

Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women.

Journal of hypertension

Frederiksen-Møller B,Jørgensen JS,Hansen MR,Krigslund O,Vogel LK,Andersen LB,Jensen BL

Mon Feb 01 00:00:00 UTC 2016

Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Andersen H,Friis UG,Hansen PB,Svenningsen P,Henriksen JE,Jensen BL

Fri May 01 00:00:00 UTC 2015

Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Andersen H,Friis UG,Hansen PB,Svenningsen P,Henriksen JE,Jensen BL

Fri May 01 00:00:00 UTC 2015

Increased expression of prostasin contributes to early-onset severe preeclampsia through inhibiting trophoblast invasion.

Journal of perinatology : official journal of the California Perinatal Association

Yang Y,Zhang J,Gong Y,Liu X,Bai Y,Xu W,Zhou R

Thu Jan 01 00:00:00 UTC 2015

Increased expression of prostasin contributes to early-onset severe preeclampsia through inhibiting trophoblast invasion.

Journal of perinatology : official journal of the California Perinatal Association

Yang Y,Zhang J,Gong Y,Liu X,Bai Y,Xu W,Zhou R

Thu Jan 01 00:00:00 UTC 2015

Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium.

Acta physiologica (Oxford, England)

Steensgaard M,Svenningsen P,Tinning AR,Nielsen TD,Jørgensen F,Kjaersgaard G,Madsen K,Jensen BL

Wed Dec 01 00:00:00 UTC 2010

Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium.

Acta physiologica (Oxford, England)

Steensgaard M,Svenningsen P,Tinning AR,Nielsen TD,Jørgensen F,Kjaersgaard G,Madsen K,Jensen BL

Wed Dec 01 00:00:00 UTC 2010

Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium.

Acta physiologica (Oxford, England)

Steensgaard M,Svenningsen P,Tinning AR,Nielsen TD,Jørgensen F,Kjaersgaard G,Madsen K,Jensen BL

Wed Dec 01 00:00:00 UTC 2010

Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium.

Acta physiologica (Oxford, England)

Steensgaard M,Svenningsen P,Tinning AR,Nielsen TD,Jørgensen F,Kjaersgaard G,Madsen K,Jensen BL

Wed Dec 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: CAP1; channel activating protease 1; Channel-activating protease 1; Prostasin; protease, serine, 8 (prostasin); Serine protease 8

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Gene Aliases: 2410039E18Rik; AI313909; C79772; CAP1; fr; mCAP1; PROSTASIN; PRSS8

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UniProt ID: (Human) Q16651, (Rat) Q9ES87

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Entrez Gene ID: (Human) 5652, (Mouse) 76560, (Rat) 192107

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Function(s)

serine-type endopeptidase activity protein binding serine-type peptidase activity sodium channel regulator activity peptidase activity hydrolase activity

Process(es)

hair follicle development proteolysis positive regulation of sodium ion transport transepithelial transport response to drug response to peptide hormone response to mineralocorticoid

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PRSS8 Polyclonal Antibody

PRSS8 Antibody (15527-1-AP) in IHC (P)

Product Details

15527-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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