Product References
Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans.
Molecular psychiatry
Hassani Nia F,Woike D,Bento I,Niebling S,Tibbe D,Schulz K,Hirnet D,Skiba M,Hönck HH,Veith K,Günther C,Scholz T,Bierhals T,Driemeyer J,Bend R,Failla AV,Lohr C,Alai MG,Kreienkamp HJ
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to indicate that both the PDZ- and the SAM-mediated interactions of Shank2 contribute to the compaction of postsynaptic protein complexes into nanoclusters, and that deficiencies in this process interfere with normal brain development in humans.
Sat Jun 01 00:00:00 UTC 2024
The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling.
Molecular neurobiology
Woike D,Tibbe D,Hassani Nia F,Martens V,Wang E,Barsukov I,Kreienkamp HJ
MA1-046 was used in Immunocytochemistry to suggest how missense variants found in autistic patients which alter SPN and Ank domains affect the synaptic function of Shank3.
Thu Feb 01 00:00:00 UTC 2024
ADAM22 ethnic-specific variant reducing binding of membrane-associated guanylate kinases causes focal epilepsy and behavioural disorder.
Brain communications
Nosková L,Fukata Y,Stránecký V,Šaligová J,Bodnárová O,Giertlová M,Fukata M,Kmoch S
MA1-046 was used in Immunoprecipitation to highlight a novel pathogenic mechanism of ADAM22 dysfunction and reconfirms an essential role of interaction of ADAM22 with membrane-associated guanylate kinases in seizure protection in humans.
Wed Nov 22 00:00:00 UTC 2023
Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
Nature communications
Lloyd BA,Han Y,Roth R,Zhang B,Aoto J
MA1-046 was used in Western Blotting to identify neurexin-3 as a critical presynaptic adhesion molecule that regulates excitatory synapse nano-organization in hippocampus.
Sat Aug 05 00:00:00 UTC 2023
Reproducible and scalable differentiation of highly pure cortical neurons from human induced pluripotent stem cells.
STAR protocols
Dannert A,Klimmt J,Cardoso Gonçalves C,Crusius D,Paquet D
MA1-046 was used in Immunocytochemistry to differentiate hiPSCs into cortical neurons with high yield and purity.
Thu May 04 00:00:00 UTC 2023
Untranslated regions of brain-derived neurotrophic factor mRNA control its translatability and subcellular localization.
The Journal of biological chemistry
Lekk I,Cabrera-Cabrera F,Turconi G,Tuvikene J,Esvald EE,Rähni A,Casserly L,Garton DR,Andressoo JO,Timmusk T,Koppel I
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to uncover two novel aspects in understanding the function of Bdnf UTRs. First, the long Bdnf 3' UTR does not repress BDNF expression in the brain. Second, exon I-derived 5' UTR has a distinct role in subcellular targeting of Bdnf mRNA.
Wed Feb 01 00:00:00 UTC 2023
High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly.
eLife
Berryer MH,Rizki G,Nathanson A,Klein JA,Trendafilova D,Susco SG,Lam D,Messana A,Holton KM,Karhohs KW,Cimini BA,Pfaff K,Carpenter AE,Rubin LL,Barrett LE
MA1-046 was used in Immunocytochemistry to demonstrate the robustness of our automated screening platform for identifying potent synaptic modulators, which can be further leveraged for scaled analyses of human synaptic mechanisms and drug discovery efforts.
Fri Apr 21 00:00:00 UTC 2023
The Effect of Sleep Deprivation and Subsequent Recovery Period on the Synaptic Proteome of Rat Cerebral Cortex.
Molecular neurobiology
Gulyássy P,Todorov-Völgyi K,Tóth V,Györffy BA,Puska G,Simor A,Juhász G,Drahos L,Kékesi KA
MA1-046 was used in Western Blot to investigate the effect of sleep deprivation and recovery period (RP) on the cortical synaptic proteome in rats.
Tue Feb 01 00:00:00 UTC 2022
MeCP2 loss-of-function dysregulates microRNAs regionally and disrupts excitatory/inhibitory synaptic transmission balance.
Hippocampus
Horvath PM,Piazza MK,Kavalali ET,Monteggia LM
MA1-046 was used in Immunocytochemistry-immunofluorescence to investigate the role of MeCP2 on miRNA synaptic change associated with Rett syndrome.
Mon Aug 01 00:00:00 UTC 2022
Comprehensive Spatial Profile of the Orphan G Protein Coupled Receptor GPRC5B Expression in Mouse Brain.
Frontiers in neuroscience
Fu W,Franchini L,Orlandi C
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to identify high levels of GPRC5B glycosylation both in transfected cells and in mouse brain.
Sat Jul 16 00:00:00 UTC 2022
Adolescence is a sensitive period for prefrontal microglia to act on cognitive development.
Science advances
Schalbetter SM,von Arx AS,Cruz-Ochoa N,Dawson K,Ivanov A,Mueller FS,Lin HY,Amport R,Mildenberger W,Mattei D,Beule D,Földy C,Greter M,Notter T,Meyer U
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to study how the microglia, the brain's resident immune cells, contribute to the maturational process.
Fri Mar 04 00:00:00 UTC 2022
An enriched environment reduces chronic stress-induced visceral pain through modulating microglial activity in the central nucleus of the amygdala.
American journal of physiology. Gastrointestinal and liver physiology
Yuan T,Orock A,Greenwood-VanMeerveld B
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to demonstrate that microglia-mediated synaptic plasticity in the CeA explains, plays a role, at least in part, in the positive effects of EE to reduce visceral hypersensitivity.
Tue Feb 01 00:00:00 UTC 2022
Cytoskeleton Protein EB3 Contributes to Dendritic Spines Enlargement and Enhances Their Resilience to Toxic Effects of Beta-Amyloid.
International journal of molecular sciences
Pchitskaya E,Rakovskaya A,Chigray M,Bezprozvanny I
MA1-046 was used in Functional Assay to show that this protein is required for a normal dendritogenesis.
Fri Feb 18 00:00:00 UTC 2022
CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons.
iScience
McSweeney D,Gabriel R,Jin K,Pang ZP,Aronow B,Pak C
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to study cell-autonomous functions of CASK in cortical excitatory induced neurons (iNs) generated from CASK knockout (KO) isogenic human embryonic stem cells (hESCs) using gene expression, morphometrics, and electrophysiology.
Fri Oct 21 00:00:00 UTC 2022
Impaired spatial navigation and age-dependent hippocampal synaptic dysfunction are associated with chronic inflammatory response in db/db mice.
The European journal of neuroscience
Al-Onaizi M,Al-Sarraf A,Braysh K,Kazem F,Al-Hussaini H,Rao M,Kilarkaje N,ElAli A
MA1-046 was used in Western Blotting to suggest that T2DM impairs cognitive function by promoting neuronal loss in the dentate gyrus and triggering an age-dependent deterioration in hippocampal synaptic integrity, associated with an aberrant neuroinflammatory response.
Thu Dec 01 00:00:00 UTC 2022
Eyeblink tract tracing with two strains of herpes simplex virus 1.
Brain research
O'Dell DE,Smith-Bell CA,Enquist LW,Engel EA,Schreurs BG
MA1-046 was used in Immunohistochemistry-immunofluorescence to examine the presence of postsynaptic marker PSD-95, which plays a role in synaptic plasticity, in HSV-772 infected and in dual-infected rats (HSV-772 and HSV-780).
Sat Oct 15 00:00:00 UTC 2022
Glutamate delta 1 receptor regulates autophagy mechanisms and affects excitatory synapse maturation in the somatosensory cortex.
Pharmacological research
Gawande DY,S Narasimhan KK,Bhatt JM,Pavuluri R,Kesherwani V,Suryavanshi PS,Shelkar GP,Dravid SM
MA1-046 was used in Western Blotting to demonstrate a novel function of GluD1 in the regulation of autophagy pathway which may underlie autism phenotypes and is relevant to the genetic association of GluD1 coding, GRID1 gene with autism and other developmental disorders.
Fri Apr 01 00:00:00 UTC 2022
SEMA6B variants cause intellectual disability and alter dendritic spine density and axon guidance.
Human molecular genetics
Cordovado A,Schaettin M,Jeanne M,Panasenkava V,Denommé-Pichon AS,Keren B,Mignot C,Doco-Fenzy M,Rodan L,Ramsey K,Narayanan V,Jones JR,Prijoles EJ,Mitchell WG,Ozmore JR,Juliette K,Torti E,Normand EA,Granger L,Petersen AK,Au MG,Matheny JP,Phornphutkul C,Chambers MK,Fernández-Ramos JA,López-Laso E,Kruer MC,Bakhtiari S,Zollino M,Morleo M,Marangi G,Mei D,Pisano T,Guerrini R,Louie RJ,Childers A,Everman DB,Isidor B,Audebert-Bellanger S,Odent S,Bonneau D,Gilbert-Dussardier B,Redon R,Bézieau S,Laumonnier F,Stoeckli ET,Toutain A,Vuillaume ML
MA1-046 was used in Immunocytochemistry-immunofluorescence to highlight the important role of SEMA6B in neuronal development, notably in spine formation and maturation and in axon guidance.
Thu Sep 29 00:00:00 UTC 2022
Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears.
International journal of molecular sciences
Van Bulck M,Brandt N,Claus RA,Gräler M,Bräuer AU
MA1-046 was used in Immunocytochemistry-immunofluorescence to underscore the potential role of lipids as a possible early diagnostic biomarker in amyloidosis-related disorders.
Sat Feb 19 00:00:00 UTC 2022
Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific.
Nature communications
Hruska M,Cain RE,Dalva MB
MA1-046 was used in Immunocytochemistry to show that the nanoscale organization of glutamate receptors containing specific subunits define distinct subsynaptic features.
Thu Feb 17 00:00:00 UTC 2022
ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.
Molecular psychiatry
Huang Y,Huang J,Zhou QX,Yang CX,Yang CP,Mei WY,Zhang L,Zhang Q,Hu L,Hu YQ,Song NN,Wu SX,Xu L,Ding YQ
MA1-046 was used in Immunocytochemistry to support the idea that ZFP804A/ZNF804A plays important roles in the cognitive functions and sensorimotor gating, and its dysfunction may contribute to SZ, particularly in the female patients.
Tue Jun 01 00:00:00 UTC 2021
Combined cellomics and proteomics analysis reveals shared neuronal morphology and molecular pathway phenotypes for multiple schizophrenia risk genes.
Molecular psychiatry
Rosato M,Stringer S,Gebuis T,Paliukhovich I,Li KW,Posthuma D,Sullivan PF,Smit AB,van Kesteren RE
MA1-046 was used in Immunocytochemistry to provide new biological functions for schizophrenia risk genes and support the idea that polygenic risk is the result of multiple small impacts on common neuronal signaling pathways.
Mon Mar 01 00:00:00 UTC 2021
Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.
Neuropharmacology
Nuwer JL,Brady ML,Povysheva NV,Coyne A,Jacob TC
MA1-046 was used in Western Blot to show that α5-GABAARs contribute to dendritic spine maturation and excitatory synapse development via a NMDAR dependent mechanism without perturbing overall neuronal excitability.
Fri Oct 01 00:00:00 UTC 2021
Novel missense mutations in PTCHD1 alter its plasma membrane subcellular localization and cause intellectual disability and autism spectrum disorder.
Human mutation
Halewa J,Marouillat S,Dixneuf M,Thépault RA,Ung DC,Chatron N,Gérard B,Ghoumid J,Lesca G,Till M,Smol T,Couque N,Ruaud L,Chune V,Grotto S,Verloes A,Vuillaume ML,Toutain A,Raynaud M,Laumonnier F
MA1-046 was used in Immunocytochemistry to find that six variants impaired the expression level of the PTCHD1 protein, and were retained in the endoplasmic reticulum suggesting abnormal protein folding.
Thu Jul 01 00:00:00 UTC 2021
Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity.
Neuroscience
Dore K,Malinow R
MA1-046 was used in Western Blot to show that PSD-95 overexpression blocks agonist induced conformational movement in the NMDA receptor intracellular domain as well as long-term depression of synaptic transmission that in NMDA receptor-dependent and ion-flux independent.
Sun Feb 21 00:00:00 UTC 2021
Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity.
Neuroscience
Dore K,Malinow R
MA1-046 was used in Western Blot to show that PSD-95 overexpression blocks agonist induced conformational movement in the NMDA receptor intracellular domain as well as long-term depression of synaptic transmission that in NMDA receptor-dependent and ion-flux independent.
Sun Feb 21 00:00:00 UTC 2021
Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells.
Cells
Soni A,Klütsch D,Hu X,Houtman J,Rund N,McCloskey A,Mertens J,Schafer ST,Amin H,Toda T
MA1-046 was used in Immunocytochemistry to demonstrate that induced neurons (NPC-iNs) by this method make synaptic connections, elicit neuronal activity-dependent cellular responses, and develop functional neuronal networks.
Mon Jul 26 00:00:00 UTC 2021
ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice.
Nature communications
Aoto K,Kato M,Akita T,Nakashima M,Mutoh H,Akasaka N,Tohyama J,Nomura Y,Hoshino K,Ago Y,Tanaka R,Epstein O,Ben-Haim R,Heyman E,Miyazaki T,Belal H,Takabayashi S,Ohba C,Takata A,Mizuguchi T,Miyatake S,Miyake N,Fukuda A,Matsumoto N,Saitsu H
MA1-046 was used in Immunohistochemistry to identify de novo and biallelic variants in ATP6V0A1, encoding the a1-subunit of the V0 domain, in individuals with developmental and epileptic encephalopathy who showed various degrees of intellectual disability, developmental delay, and epilepsy.
Thu Apr 08 00:00:00 UTC 2021
Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines.
Frontiers in cellular neuroscience
Acuña-Hinrichsen F,Covarrubias-Pinto A,Ishizuka Y,Stolzenbach MF,Martin C,Salazar P,Castro MA,Bramham CR,Otth C
MA1-046 was used in Immunocytochemistry to demonstrate that HSV-1 infection induces structural disassembly and functional deregulation in cultured cortical neurons, an altered glutamate response, Arc accumulation within the somata, and decreased expression of spine scaffolding-like proteins such as PSD-95, Drebrin and CaMKIIβ.
Sat Nov 11 00:00:00 UTC 2023
Quantifying molecular aggregation by super resolution microscopy within an excitatory synapse from mouse hippocampal neurons.
STAR protocols
Kedia S,Ramanan N,Nair D
MA1-046 was used in Immunocytochemistry to evaluate the nanoscale organization heterogeneity between neuronal subcompartments through a super-resolution microscopy paradigm.
Fri Jun 18 00:00:00 UTC 2021
Age-Dependent Contributions of NMDA Receptors and L-Type Calcium Channels to Long-Term Depression in the Piriform Cortex.
International journal of molecular sciences
Rajani V,Maziar A,Man KNM,Hell JW,Yuan Q
MA1-046 was used in Immunohistochemistry to study the expression and contribution of N-methyl-D-aspartate receptors (NMDARs) and L-type calcium channels (LTCCs) in long-term depression.
Fri Dec 17 00:00:00 UTC 2021
Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function.
Cell reports
Blockus H,Rolotti SV,Szoboszlay M,Peze-Heidsieck E,Ming T,Schroeder A,Apostolo N,Vennekens KM,Katsamba PS,Bahna F,Mannepalli S,Ahlsen G,Honig B,Shapiro L,de Wit J,Losonczy A,Polleux F
MA1-046 was used in Western Blotting to identify a trans-synaptic complex linking the establishment of synaptic specificity to circuit function.
Tue Oct 19 00:00:00 UTC 2021
Human vault RNA1-1, but not vault RNA2-1, modulates synaptogenesis.
Communicative & integrative biology
Wakatsuki S,Ohno M,Araki T
MA1-046 was used in Immunocytochemistry-immunoflourescence to uncover the function of the different vtRNA paralogs.
Wed Apr 14 00:00:00 UTC 2021
Disruption of rat deep cerebellar perineuronal net alters eyeblink conditioning and neuronal electrophysiology.
Neurobiology of learning and memory
O'Dell DE,Schreurs BG,Smith-Bell C,Wang D
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to investigate the role of perineuronal net (PNN) in cerebellar learning in the deep cerebellar nuclei (DCN) and demonstrate PNN degradation may erase sex differences in delay conditioning.
Fri Jan 01 00:00:00 UTC 2021
A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function.
Science advances
Xiao MF,Roh SE,Zhou J,Chien CC,Lucey BP,Craig MT,Hayes LN,Coughlin JM,Leweke FM,Jia M,Xu D,Zhou W,Conover Talbot C,Arnold DB,Staley M,Jiang C,Reti IM,Sawa A,Pelkey KA,McBain CJ,Savonenko A,Worley PF
MA1-046 was used in Western Blot to show that the identified vulnerability of NPTX2 function can provide a framework for assessing the impact of genetics and the intersection with stress.
Fri Nov 26 00:00:00 UTC 2021
Neurofascin Is a Novel Component of Rod Photoreceptor Synapses in the Outer Retina.
Frontiers in neural circuits
Pourhoseini S,Goswami-Sewell D,Zuniga-Sanchez E
MA1-046 was used in Immunohistochemistry to suggest a new role of Nfasc in rod synapses within the mouse outer retina.
Thu Jan 13 00:00:00 UTC 2022
Transsynaptic N-Cadherin Adhesion Complexes Control Presynaptic Vesicle and Bulk Endocytosis at Physiological Temperature.
Frontiers in cellular neuroscience
Dagar S,Teng Z,Gottmann K
MA1-046 was used in Immunocytochemistry to provide a novel, adhesion protein-mediated mechanism for efficient coupling of exo- and endocytosis.
Fri Nov 12 00:00:00 UTC 2021
RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Cell
Wang J,Miao Y,Wicklein R,Sun Z,Wang J,Jude KM,Fernandes RA,Merrill SA,Wernig M,Garcia KC,Südhof TC
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to show how BAI binding to RTN4/NoGo receptors represents a receptor-ligand axis that, enabled by rare post-translational modifications, controls development of synaptic circuits.
Wed Nov 24 00:00:00 UTC 2021
Synaptic changes and the response of microglia in a light-induced photoreceptor degeneration model.
Molecular vision
Xu S,Zhang P,Zhang M,Wang X,Li G,Xu G,Ni Y
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to explore synaptic changes and the response of microglia in a light-induced photoreceptor degeneration model.
Fri Dec 10 00:00:00 UTC 2021
Adult medial habenula neurons require GDNF receptor GFRα1 for synaptic stability and function.
PLoS biology
Fernández-Suárez D,Krapacher FA,Pietrajtis K,Andersson A,Kisiswa L,Carrier-Ruiz A,Diana MA,Ibáñez CF
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to define the presence of GluA1/GluA2 (Ca2+ impermeable) as well as GluA1/GluA4 (Ca2+ permeable), uncover an unexpected function for GFRa1 in the maintenance and function of adult glutamatergic synapses and reveal a potential new mechanism for regulating synaptic plasticity in the septohabenulointerpeduncular pathway and attuning of anxiety and fear behaviors.
Mon Nov 01 00:00:00 UTC 2021
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.
Nature
Yu K,Lin CJ,Hatcher A,Lozzi B,Kong K,Huang-Hobbs E,Cheng YT,Beechar VB,Zhu W,Zhang Y,Chen F,Mills GB,Mohila CA,Creighton CJ,Noebels JL,Scott KL,Deneen B
MA1-046 was used in Immunohistochemistry to develop a high-throughput in vivo screening platform and discover several driver variants of PIK3CA, using a native mouse model of glioblastoma.
Sat Feb 01 00:00:00 UTC 2020
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.
Science (New York, N.Y.)
Suzuki K,Elegheert J,Song I,Sasakura H,Senkov O,Matsuda K,Kakegawa W,Clayton AJ,Chang VT,Ferrer-Ferrer M,Miura E,Kaushik R,Ikeno M,Morioka Y,Takeuchi Y,Shimada T,Otsuka S,Stoyanov S,Watanabe M,Takeuchi K,Dityatev A,Aricescu AR,Yuzaki M
MA1-046 was used in Immunohistochemistry to design and characterize CPTX, a synthetic synaptic organizer combining structural elements from cerebellin-1 and neuronal pentraxin-1.
Fri Aug 28 00:00:00 UTC 2020
Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility.
Neuron
Kapur M,Ganguly A,Nagy G,Adamson SI,Chuang JH,Frankel WN,Ackerman SL
MA1-046 was used in Immunohistochemistry to demonstrate that mutations in a neuronally enriched arginine tRNA, n-Tr20, increased seizure threshold and altered synaptic transmission.
Wed Oct 14 00:00:00 UTC 2020
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
The EMBO journal
Weinert S,Gimber N,Deuschel D,Stuhlmann T,Puchkov D,Farsi Z,Ludwig CF,Novarino G,López-Cayuqueo KI,Planells-Cases R,Jentsch TJ
MA1-046 was used in Western Blotting to generate Clcn3unc/unc mice in which ClC-3 is converted into a Cl- channel.
Mon May 04 00:00:00 UTC 2020
Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.
The EMBO journal
Alsabban AH,Morikawa M,Tanaka Y,Takei Y,Hirokawa N
MA1-046 was used in Immunocytochemistry to propose that KIF3B transports NR2A/APC complex and that its dysfunction is responsible for SCZ pathogenesis.
Thu Jan 02 00:00:00 UTC 2020
Enhanced Prefrontal Neuronal Activity and Social Dominance Behavior in Postnatal Forebrain Excitatory Neuron-Specific Cyfip2 Knock-Out Mice.
Frontiers in molecular neuroscience
Zhang Y,Kang Hyae R,Lee SH,Kim Y,Ma R,Jin C,Lim JE,Kim S,Kang Y,Kang H,Kim SY,Kwon SK,Choi SY,Han K
MA1-046 was used in Western Blot to provide additional insights into the functions of CYFIP2 in the adult brain.
Tue Nov 17 00:00:00 UTC 2020
The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform.
Frontiers in molecular neuroscience
Jin C,Kang H,Yoo T,Ryu JR,Yoo YE,Ma R,Zhang Y,Kang HR,Kim Y,Seong H,Bang G,Park S,Kwon SK,Sun W,Kim H,Kim JY,Kim E,Han K
MA1-046 was used in Western Blotting to validate that the increased Shank3 mRNA in Shank3B KO brains produced an unusual ∼60 kDa Shank3 isoform (Shank3-N), which did not properly localize to the synaptic compartment.
Sat Jan 30 00:00:00 UTC 2021
Mitochondrial-associated impairments of temozolomide on neural stem/progenitor cells and hippocampal neurons.
Mitochondrion
Lomeli N,Di K,Pearre DC,Chung TF,Bota DA
MA1-046 was used in Immunocytochemistry-immunoflourescence to examine the mitochondrial-mediated mechanisms involving TMZ-induced neural damage in primary rat neural stem/progenitor cells (NSC) and hippocampal neurons.
Fri May 01 00:00:00 UTC 2020
Proteomic comparison of different synaptosome preparation procedures.
Amino acids
Gulyássy P,Puska G,Györffy BA,Todorov-Völgyi K,Juhász G,Drahos L,Kékesi KA
MA1-046 was used in Western Blotting to examine five synaptosome isolation methods from a proteomic point of view by the means of electron microscopy, Western blot, and liquid chromatography-mass spectrometry to compare their efficiency in the isolation of synaptosomes and depletion of contaminating subcellular structures.
Tue Dec 01 00:00:00 UTC 2020
Prelimbic cortical targets of ventromedial thalamic projections include inhibitory interneurons and corticostriatal pyramidal neurons in the rat.
Brain structure & function
Sieveritz B,Arbuthnott GW
MA1-046 was used in Immunohistochemistry-immunofluorescence to provide evidence that most ventromedial thalamic input to pyramidal neurons is provided to corticostriatal neurons and that overall more contacts are made onto the population of excitatory than onto the population of inhibitory neurons.
Tue Sep 01 00:00:00 UTC 2020
A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons.
Journal of neuroscience methods
Ishizuka Y,Bramham CR
MA1-046 was used in Immunocytochemistry to present a simplified cryopreservation method for rodent primary hippocampal and cortical neurons from embryonic day 18.5 fetuses, using DMSO-containing traditional cell freezing medium.
Sun Mar 01 00:00:00 UTC 2020
The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation.
Cell reports
Lo LH,Dong R,Lyu Q,Lai KO
MA1-046 was used in Immunocytochemistry to unravel arginine methylation as a crucial regulatory mechanism for actin cytoskeleton during synapse development.
Tue Jun 09 00:00:00 UTC 2020
The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation.
Cell reports
Lo LH,Dong R,Lyu Q,Lai KO
MA1-046 was used in Immunocytochemistry to unravel arginine methylation as a crucial regulatory mechanism for actin cytoskeleton during synapse development.
Tue Jun 09 00:00:00 UTC 2020
Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer's disease.
Acta neuropathologica communications
Lackie RE,Marques-Lopes J,Ostapchenko VG,Good S,Choy WY,van Oosten-Hawle P,Pasternak SH,Prado VF,Prado MAM
MA1-046 was used in Western Blotting to conclude that despite the protective effects of STI1 in C. elegans and in mammalian cultured neurons, in vivo, the predominant effect of elevated STI1 is deleterious in AD.
Fri Aug 21 00:00:00 UTC 2020
Differential Scaling of Synaptic Molecules within Functional Zones of an Excitatory Synapse during Homeostatic Plasticity.
eNeuro
Venkatesan S,Subramaniam S,Rajeev P,Chopra Y,Jose M,Nair D
MA1-046 was used in Immunocytochemistry to examine the scaling of presynaptic and postsynaptic scaffolding molecules along with neurotransmitter receptors in primary cultures from mouse and rat hippocampal neurons.
Fri Jun 18 00:00:00 UTC 2021
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
eLife
Vevea JD,Chapman ER
MA1-046 was used in Immunocytochemistry to develop knockoff and apply it, for the first time, to study the function of SYT1.
Tue Jun 09 00:00:00 UTC 2020
Truncating mutations in SHANK3 associated with global developmental delay interfere with nuclear β-catenin signaling.
Journal of neurochemistry
Hassani Nia F,Woike D,Kloth K,Kortüm F,Kreienkamp HJ
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to illustrate that truncating mutations in SHANK3 not only lead to a reduction in Shank3 protein available at postsynaptic sites but also negatively affects the Wnt signaling pathway.
Sun Nov 01 00:00:00 UTC 2020
Influence of Aging on the Retina and Visual Motion Processing for Optokinetic Responses in Mice.
Frontiers in neuroscience
Sugita Y,Yamamoto H,Maeda Y,Furukawa T
MA1-046 was used in Immunohistochemistry to examine the detailed visual characteristics throughout the initial and late phases of optokinetic responses affected by aging.
Sat Dec 19 00:00:00 UTC 2020
Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus.
Molecular autism
Hassani Nia F,Woike D,Martens V,Klüssendorf M,Hönck HH,Harder S,Kreienkamp HJ
MA1-046 was used in Immunocytochemistry-immunoflourescence to study the interactions of δ-catenin with the Shank3 scaffolding proteins.
Wed Oct 28 00:00:00 UTC 2020
An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility.
Science advances
Iwata S,Morikawa M,Takei Y,Hirokawa N
MA1-046 was used in Western Blot, Immunocytochemistry to show that the molecular motor KIF17 is locally degraded and synthesized in an N-methyl-d-aspartate receptor (NMDAR)-mediated activity-dependent manner.
Tue Dec 01 00:00:00 UTC 2020
An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility.
Science advances
Iwata S,Morikawa M,Takei Y,Hirokawa N
MA1-046 was used in Western Blot, Immunocytochemistry to show that the molecular motor KIF17 is locally degraded and synthesized in an N-methyl-d-aspartate receptor (NMDAR)-mediated activity-dependent manner.
Tue Dec 01 00:00:00 UTC 2020
Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.
Neurobiology of aging
Klaus C,Hansen JN,Ginolhac A,Gérard D,Gnanapragassam VS,Horstkorte R,Rossdam C,Buettner FFR,Sauter T,Sinkkonen L,Neumann H,Linnartz-Gerlach B
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to investigate Siglec receptors in neurons.
Wed Apr 01 00:00:00 UTC 2020
Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation.
Molecular cell
Zhang W,Chuang YA,Na Y,Ye Z,Yang L,Lin R,Zhou J,Wu J,Qiu J,Savonenko A,Leahy DJ,Huganir R,Linden DJ,Worley PF
MA1-046 was used in Western Blotting to provide an atomic model for dynamic and local control of Arc function underlying synaptic plasticity and memory.
Thu Jul 11 00:00:00 UTC 2019
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Neuron
Marro SG,Chanda S,Yang N,Janas JA,Valperga G,Trotter J,Zhou B,Merrill S,Yousif I,Shelby H,Vogel H,Kalani MYS,Südhof TC,Wernig M
MA1-046 was used in Immunocytochemistry to reveal contrasting roles of NLGN4 in human and mouse neurons, suggesting that human evolution has impacted even fundamental cell biological processes generally assumed to be highly conserved.
Wed Aug 21 00:00:00 UTC 2019
Nucleome Dynamics during Retinal Development.
Neuron
Norrie JL,Lupo MS,Xu B,Al Diri I,Valentine M,Putnam D,Griffiths L,Zhang J,Johnson D,Easton J,Shao Y,Honnell V,Frase S,Miller S,Stewart V,Zhou X,Chen X,Dyer MA
MA1-046 was used in Immunohistochemistry to demonstrate the importance of performing integrated analysis of the structure and organization of chromatin to identify cell-type- and developmental stage-specific regulatory elements during neurogenesis.
Wed Nov 06 00:00:00 UTC 2019
Brain ischemic insult induces cofilin rod formation leading to synaptic dysfunction in neurons.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Shu L,Chen B,Chen B,Xu H,Wang G,Huang Y,Zhao Y,Gong H,Jiang M,Chen L,Liu X,Wang Y
MA1-046 was used in Immunohistochemistry-immunofluorescence to demonstrate that the formation of cofilin rods after brain ischemic insult leads to impairment of synaptic structure and function in neurons.
Fri Nov 01 00:00:00 UTC 2019
Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity.
Frontiers in molecular neuroscience
Paul A,Nawalpuri B,Shah D,Sateesh S,Muddashetty RS,Clement JP
MA1-046 was used in Western Blotting to study the molecular mechanism underlying altered neuronal protein synthesis in Syngap1-/+ mutations.
Thu Oct 01 00:00:00 UTC 2020
UBE3A regulates the transcription of IRF, an antiviral immunity.
Human molecular genetics
Furumai R,Tamada K,Liu X,Takumi T
MA1-046 was used in Western Blotting to suggest a function for UBE3A as a transcriptional regulator of the immune system in the brain.
Sat Jun 15 00:00:00 UTC 2019
Redundant and nonredundant organismal functions of EPS15 and EPS15L1.
Life science alliance
Milesi C,Alberici P,Pozzi B,Oldani A,Beznoussenko GV,Raimondi A,Soppo BE,Amodio S,Caldieri G,Malabarba MG,Bertalot G,Confalonieri S,Parazzoli D,Mironov AA,Tacchetti C,Di Fiore PP,Sigismund S,Offenhäuser N
MA1-046 was used in Western Blotting to characterise the redundant and nonredundant functions of EPS15 and EPS15L1.
Fri Feb 01 00:00:00 UTC 2019
Amyloid-β oligomers suppress subunit-specific glutamate receptor increase during LTP.
Alzheimer's & dementia (New York, N. Y.)
Tanaka H,Sakaguchi D,Hirano T
MA1-046 was used in Immunocytochemistry-immunoflourescence to show that AβOs primarily inhibit the increase in the number of GluA1 homomers and suppress hippocampal long-term potentiation expression.
Mon Apr 11 00:00:00 UTC 2022
CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment.
Cell reports
Subramanian J,Michel K,Benoit M,Nedivi E
MA1-046 was used in Immunocytochemistry to examine the role of activity and CPG15 in dendritic spine formation, PSD95 recruitment and synapse stabilisation.
Tue Aug 06 00:00:00 UTC 2019
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.
Acta neuropathologica communications
Verschuuren M,Verstraelen P,García-Díaz Barriga G,Cilissen I,Coninx E,Verslegers M,Larsen PH,Nuydens R,De Vos WH
MA1-046 was used in Immunocytochemistry-immunoflourescence to illustrate that profiling microscopy images with deep coverage enables sensitive interrogation of neuronal connectivity and allows exposing a pharmacological window for targeted treatments.
Tue Jun 04 00:00:00 UTC 2019
In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
Nature communications
Spence EF,Dube S,Uezu A,Locke M,Soderblom EJ,Soderling SH
MA1-046 was used in Immunocytochemistry to study the molecular mechanisms that underlie excitatory synaptogenesis.
Wed Jan 23 00:00:00 UTC 2019
Higher Levels of Protein Palmitoylation in the Frontal Cortex across Aging Were Associated with Reference Memory and Executive Function Declines.
eNeuro
Zamzow DR,Elias V,Acosta VA,Escobedo E,Magnusson KR
MA1-046 was used in Western Blotting to examine some of the factors that lead to the differences in the palmitoylation levels of NMDAR complex proteins in the frontal cortex of aged animals.
Tue May 21 00:00:00 UTC 2019
Paroxysmal and cognitive phenotypes in Prrt2 mutant mice.
Genes, brain, and behavior
Robertson L,Featherby T,Howell S,Hughes J,Thomas P
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to validate the utility of Prrt2 mutant mice, displaying paroxysomal and cognitive defect features, for in vivo episodic disease studies.
Sat Jun 01 00:00:00 UTC 2019
Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission.
eNeuro
Chander P,Kennedy MJ,Winckler B,Weick JP
MA1-046 was used in Immunocytochemistry to characterize the function of neuron-specific gene 2 in mouse and human neurons.
Tue May 21 00:00:00 UTC 2019
A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity.
Neuron
Schroeder A,Vanderlinden J,Vints K,Ribeiro LF,Vennekens KM,Gounko NV,Wierda KD,de Wit J
MA1-046 was used in Immunohistochemistry-immunofluorescence to show that hippocampal CA1 pyramidal neurons express multiple synaptogenic LRR proteins that differentially distribute to the major excitatory inputs on their apical dendrites.
Wed Jul 25 00:00:00 UTC 2018
3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity.
Developmental cell
Papadimitriou C,Celikkaya H,Cosacak MI,Mashkaryan V,Bray L,Bhattarai P,Brandt K,Hollak H,Chen X,He S,Antos CL,Lin W,Thomas AK,Dahl A,Kurth T,Friedrichs J,Zhang Y,Freudenberg U,Werner C,Kizil C
MA1-046 was used in Immunocytochemistry-immunoflourescence to conclude that our culture system enables a reductionist investigation of regulation of human NSC plasticity for the identification of potential therapeutic targets for intervention in AD.
Mon Jul 02 00:00:00 UTC 2018
X10 expansion microscopy enables 25-nm resolution on conventional microscopes.
EMBO reports
Truckenbrodt S,Maidorn M,Crzan D,Wildhagen H,Kabatas S,Rizzoli SO
MA1-046 was used in Immunohistochemistry-immunofluorescence to develop a novel microscopy protocol enabling 25-nm resolution on conventional microscopes.
Sat Sep 01 00:00:00 UTC 2018
α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kerov V,Laird JG,Joiner ML,Knecht S,Soh D,Hagen J,Gardner SH,Gutierrez W,Yoshimatsu T,Bhattarai S,Puthussery T,Artemyev NO,Drack AV,Wong RO,Baker SA,Lee A
MA1-046 was used in Immunocytochemistry-immunoflourescence to investigate the retinal function of the α2δ-4 subunit of voltage-gated Cav1.4 L-type channels.
Wed Jul 04 00:00:00 UTC 2018
α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kerov V,Laird JG,Joiner ML,Knecht S,Soh D,Hagen J,Gardner SH,Gutierrez W,Yoshimatsu T,Bhattarai S,Puthussery T,Artemyev NO,Drack AV,Wong RO,Baker SA,Lee A
MA1-046 was used in Immunocytochemistry-immunoflourescence to investigate the retinal function of the α2δ-4 subunit of voltage-gated Cav1.4 L-type channels.
Wed Jul 04 00:00:00 UTC 2018
α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kerov V,Laird JG,Joiner ML,Knecht S,Soh D,Hagen J,Gardner SH,Gutierrez W,Yoshimatsu T,Bhattarai S,Puthussery T,Artemyev NO,Drack AV,Wong RO,Baker SA,Lee A
MA1-046 was used in Immunocytochemistry-immunoflourescence to investigate the retinal function of the α2δ-4 subunit of voltage-gated Cav1.4 L-type channels.
Wed Jul 04 00:00:00 UTC 2018
α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kerov V,Laird JG,Joiner ML,Knecht S,Soh D,Hagen J,Gardner SH,Gutierrez W,Yoshimatsu T,Bhattarai S,Puthussery T,Artemyev NO,Drack AV,Wong RO,Baker SA,Lee A
MA1-046 was used in Immunocytochemistry-immunoflourescence to investigate the retinal function of the α2δ-4 subunit of voltage-gated Cav1.4 L-type channels.
Wed Jul 04 00:00:00 UTC 2018
Combinatorial Effects of Alpha- and Gamma-Protocadherins on Neuronal Survival and Dendritic Self-Avoidance.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ing-Esteves S,Kostadinov D,Marocha J,Sing AD,Joseph KS,Laboulaye MA,Sanes JR,Lefebvre JL
MA1-046 was used in Immunohistochemistry-immunofluorescence to assess the functional interactions between protocadherin a and protocadherin g clusters.
Wed Mar 14 00:00:00 UTC 2018
Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Choi TY,Lee SH,Kim YJ,Bae JR,Lee KM,Jo Y,Kim SJ,Lee AR,Choi S,Choi LM,Bang S,Song MR,Chung J,Lee KJ,Kim SH,Park CS,Choi SY
MA1-046 was used in Western Blotting to investigate the role of cereblon in synaptic function and animal behaviour.
Wed Apr 04 00:00:00 UTC 2018
The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tu YK,Duman JG,Tolias KF
MA1-046 was used in Immunocytochemistry-immunoflourescence to study the requirement of BAI1 in vivo for hippocampal spine development, and identify three distinct signalling mechanisms mediating BAI1's prosynaptogenic functions.
Wed Sep 26 00:00:00 UTC 2018
Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Omotade OF,Rui Y,Lei W,Yu K,Hartzell HC,Fowler VM,Zheng JQ
MA1-046 was used in Immunohistochemistry to study the mechanism by which the actin cytoskeleton regulates dendrite development and spine formation.
Wed Nov 28 00:00:00 UTC 2018
Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation.
Frontiers in molecular neuroscience
Yamagata M,Duan X,Sanes JR
MA1-046 was used in Immunocytochemistry to propose that cadherins promote high affinity contacts between appropriate partners, which then enable synaptic differentiation.
Thu Nov 11 00:00:00 UTC 2021
Axonal abnormalities in vanishing white matter.
Annals of clinical and translational neurology
Klok MD,Bugiani M,de Vries SI,Gerritsen W,Breur M,van der Sluis S,Heine VM,Kole MHP,Baron W,van der Knaap MS
MA1-046 was used in Immunocytochemistry to study the occurrence and development of axonal pathology and the influence of astrocytes in vanishing white matter.
Sun Apr 01 00:00:00 UTC 2018
Neonatal maternal deprivation impairs localized de novo activity-induced protein translation at the synapse in the rat hippocampus.
Bioscience reports
Ahmad F,Salahuddin M,Alsamman K,Herzallah HK,Al-Otaibi ST
MA1-046 was used in Western Blotting to elucidate the molecular mechanisms underlying the detrimental alterations in brain functions induced by early-life stress.
Fri Jun 29 00:00:00 UTC 2018
Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model.
Frontiers in behavioral neuroscience
Kang S,Ha S,Park H,Nam E,Suh WH,Suh YH,Chang KA
MA1-046 was used in Western Blotting to investigate the therapeutic effects of carboxy-dehydroevodiamine-HCl and the underlying mechanism in a transgenic mouse model of Alzheimer's disease.
Wed Sep 30 00:00:00 UTC 2020
Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome.
Molecular cell
Ramachandran KV,Fu JM,Schaffer TB,Na CH,Delannoy M,Margolis SS
MA1-046 was used in Western Blot to find that the NMP degrades exclusively a large fraction of ribosome-associated nascent polypeptides that are being newly synthesized during neuronal stimulation.
Thu Jul 05 00:00:00 UTC 2018
PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
Cell reports
Schaffer TB,Smith JE,Cook EK,Phan T,Margolis SS
MA1-046 was used in Western Blotting to show that, mediated by ephexin5), PKCε reduces the number of dendritic spines, which are sites of eventual synapse formation on developing dendrites.
Tue Nov 27 00:00:00 UTC 2018
Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models.
Nature communications
Zhang H,Zhang C,Vincent J,Zala D,Benstaali C,Sainlos M,Grillo-Bosch D,Daburon S,Coussen F,Cho Y,David DJ,Saudou F,Humeau Y,Choquet D
MA1-046 was used in Proximity Ligation Assay to study a mechanism underlying hippocampal synaptic and memory dysfunction in Huntington's disease, and highlight AMPAR surface diffusion as a promising therapeutic target.
Mon Oct 15 00:00:00 UTC 2018
Developmental lead (Pb)-induced deficits in hippocampal protein translation at the synapses are ameliorated by ascorbate supplementation.
Neuropsychiatric disease and treatment
Ahmad F,Salahuddin M,Alsamman K,AlMulla AA,Salama KF
MA1-046 was used in Western Blotting to assess the alterations in the synapse-specific translation induced by developmental lead exposure.
Wed Mar 30 00:00:00 UTC 2022
Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons.
Journal of neurochemistry
Mangold CA,Yao PJ,Du M,Freeman WM,Benkovic SJ,Szpara ML
MA1-046 was used in Immunocytochemistry-immunofluorescence to provide insight into potential purine biosynthetic mechanisms utilized within neurons during homeostasis as well as viral infection.
Thu Mar 01 00:00:00 UTC 2018
NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation.
The Journal of biological chemistry
Paradis-Isler N,Boehm J
MA1-046 was used in Immunocytochemistry-immunoflourescence to study the mechanisms regulating neuronal AGO proteins.
Fri Jun 15 00:00:00 UTC 2018
Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors.
Neuron
Abrahamsson T,Chou CYC,Li SY,Mancino A,Costa RP,Brock JA,Nuro E,Buchanan KA,Elgar D,Blackman AV,Tudor-Jones A,Oyrer J,Farmer WT,Murai KK,Sjöström PJ
MA1-046 was used in Western Blotting to show that presynaptic NMDA receptors sometimes signal metabotropically and support emerging principle that evoke and spontaneous release are distinct processes.
Wed Nov 15 00:00:00 UTC 2017
Structural Similarities between Neuregulin 1-3 Isoforms Determine Their Subcellular Distribution and Signaling Mode in Central Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vullhorst D,Ahmad T,Karavanova I,Keating C,Buonanno A
MA1-046 was used in Immunohistochemistry to study the subcellular distribution and processing of neuregulin isoforms in rat hipppocampal neurons.
Wed May 24 00:00:00 UTC 2017
The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kozuka T,Chaya T,Tamalu F,Shimada M,Fujimaki-Aoba K,Kuwahara R,Watanabe SI,Furukawa T
MA1-046 was used in Immunohistochemistry to investigate the role of neurotransmission from photoreceptor cells to ON bipolar cells in development.
Wed Oct 11 00:00:00 UTC 2017
Cellular and Molecular Analysis of Dendritic Morphogenesis in a Retinal Cell Type That Senses Color Contrast and Ventral Motion.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu J,Sanes JR
MA1-046 was used in Immunohistochemistry to elucidate cellular and molecular mechanisms that shape dendritic arbors and synaptic distribution, enabling a single retinal ganglion cell connectivity and function.
Wed Dec 13 00:00:00 UTC 2017
A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus.
Journal of Alzheimer's disease : JAD
Brooks SW,Dykes AC,Schreurs BG
MA1-046 was used in Western Blot to report that increase in serum cholesterol, induced by feeding rabbits a high-cholesterol diet, is associated with higher levels of 27-OHC in the brain as well as increased levels of neurodegeneration in the hippocampus.
Wed Feb 21 00:00:00 UTC 2018
Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model.
Brain research
Song L,Yu A,Murray K,Cortopassi G
MA1046 was used in immunohistochemistry - frozen section and western blot to find that complex 1 -deficient Ndufs4-/- mice present with acute vision loss around p30, and this vision loss is coincident with an 'inflammatory wave'
Wed Feb 15 00:00:00 UTC 2017
The short- and long-term proteomic effects of sleep deprivation on the cortical and thalamic synapses.
Molecular and cellular neurosciences
Simor A,Györffy BA,Gulyássy P,Völgyi K,Tóth V,Todorov MI,Kis V,Borhegyi Z,Szabó Z,Janáky T,Drahos L,Juhász G,Kékesi KA
MA1-046 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to support the synaptic homeostasis hypothesis function of sleep and highlight the long-term influence of SD after the recovery sleep period, mostly on cortical synapses.
Wed Mar 01 00:00:00 UTC 2017
Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons.
PloS one
Joe IS,Kim JH,Kim H,Hong JH,Kim M,Park M
MA1046 was used in immunohistochemistry to identify putative molecules, biological processes, and functional pathways connected to cyclin Y-related cell division
Thu Sep 07 00:00:00 UTC 2017
Hyaluronan synthesis by developing cortical neurons in vitro.
Scientific reports
Fowke TM,Karunasinghe RN,Bai JZ,Jordan S,Gunn AJ,Dean JM
MA1046 was used in immunocytochemistry to assess the localization of hyaluronan and hyaluronan synthases during the development of cortical neurons
Mon Mar 13 00:00:00 UTC 2017
Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice.
Nature communications
Aloisi E,Le Corf K,Dupuis J,Zhang P,Ginger M,Labrousse V,Spatuzza M,Georg Haberl M,Costa L,Shigemoto R,Tappe-Theodor A,Drago F,Vincenzo Piazza P,Mulle C,Groc L,Ciranna L,Catania MV,Frick A
MA1-046 was used in Immunocytochemistry to provide a mechanistic link between changes of mGluR5 dynamics and pathological phenotypes of Fragile X Syndrome.
Tue Oct 24 00:00:00 UTC 2017
Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.
Cell reports
Xu J,Marshall JJ,Fernandes HB,Nomura T,Copits BA,Procissi D,Mori S,Wang L,Zhu Y,Swanson GT,Contractor A
MA1-046 was used in Western Blotting to demonstrate that alterations in striatal function dominate the behavioural phenotype in mice without kainate receptors.
Tue Feb 21 00:00:00 UTC 2017
Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.
Cell reports
Xu J,Marshall JJ,Fernandes HB,Nomura T,Copits BA,Procissi D,Mori S,Wang L,Zhu Y,Swanson GT,Contractor A
MA1-046 was used in Western Blotting to demonstrate that alterations in striatal function dominate the behavioural phenotype in mice without kainate receptors.
Tue Feb 21 00:00:00 UTC 2017
Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c.
Nature neuroscience
Chen YC,Kuo HY,Bornschein U,Takahashi H,Chen SY,Lu KM,Yang HY,Chen GM,Lin JR,Lee YH,Chou YC,Cheng SJ,Chien CT,Enard W,Hevers W,Pääbo S,Graybiel AM,Liu FC
MA1046 was used in western blot to propose that Foxp2-Mef2C signaling is important for corticostriatal circuit formation
Tue Nov 01 00:00:00 UTC 2016
Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
The Journal of clinical investigation
Rué L,Bañez-Coronel M,Creus-Muncunill J,Giralt A,Alcalá-Vida R,Mentxaka G,Kagerbauer B,Zomeño-Abellán MT,Aranda Z,Venturi V,Pérez-Navarro E,Estivill X,Martí E
MA1-046 was used in Western Blotting to demonstrate that a locked nucleic acid-modified antisense oligonucleotide, complementary to the CAG repeat, preferentially binds mutant Huntingtin without affecting Huntingtin mRNA or protein levels.
Tue Nov 01 00:00:00 UTC 2016
Dopaminergic abnormalities in Hdac6-deficient mice.
Neuropharmacology
Fukada M,Nakayama A,Mamiya T,Yao TP,Kawaguchi Y
MA1046 was used in western blot to examine the dopaminergic abnormalities in Histone deacetylase 6 knockout mice
Tue Nov 01 00:00:00 UTC 2016
Ontogenic Profile and Synaptic Distribution of GluN3 Proteins in the Rat Brain and Hippocampal Neurons.
Neurochemical research
Wee KS,Tan FC,Cheong YP,Khanna S,Low CM
MA1-046 was used in immunoprecipitation and western blot to survey rat brain and hippocampal neurons by looking at the ontogenic profile and synaptic distribution of GluN3 proteins
Mon Feb 01 00:00:00 UTC 2016
Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy.
Neurology. Genetics
Muona M,Fukata Y,Anttonen AK,Laari A,Palotie A,Pihko H,Lönnqvist T,Valanne L,Somer M,Fukata M,Lehesjoki AE
MA1-046 was used in Immunoprecipitation to identify the molecular genetic basis of a syndrome characterised by rapidly progressing cerebral atrophy, intractable seizures, and intellectual disability.
Mon Feb 01 00:00:00 UTC 2016
NDE1 and GSK3β Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking.
ACS chemical neuroscience
Ogawa F,Murphy LC,Malavasi EL,O'Sullivan ST,Torrance HS,Porteous DJ,Millar JK
MA1-046 was used in western blot to determine how GSK3Beta and NDE1 associate with TRAK1 and regulate axonal mitochondrial motility and identify cyclic AMP as the novel modulator of axonal mitochondrial trafficking
Wed May 18 00:00:00 UTC 2016
Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse.
Translational psychiatry
Fujiwara K,Fujita Y,Kasai A,Onaka Y,Hashimoto H,Okada H,Yamashita T
MA1-046 was used in immunocytochemistry to characterize mice with a deletion of JMJD2B in neurons showing hyperactive behavior, defective spine maturation, and memory deficits
Tue Mar 29 00:00:00 UTC 2016
Neuregulin-1 attenuates cognitive function impairments in a transgenic mouse model of Alzheimer's disease.
Cell death & disease
Ryu J,Hong BH,Kim YJ,Yang EJ,Choi M,Kim H,Ahn S,Baik TK,Woo RS,Kim HS
MA1046 was used in immunohistochemistry to demonstrate that an intracerebroventricular infusion of neuregulin 1 attenuates cognitive impairments in an animal model of Alzheimer's disease
Thu Feb 25 00:00:00 UTC 2016
Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2.
Frontiers in cellular neuroscience
Kumar A,Paeger L,Kosmas K,Kloppenburg P,Noegel AA,Peche VS
MA1046 was used in immunocytochemistry to explore the role of CAP2 in the brain
Wed Aug 10 00:00:00 UTC 2016
Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins.
PloS one
Heintz TG,Eva R,Fawcett JW
MA1-046 was used in western blot propose that Eph/ephrin signaling modulates proximal dendritic spines in Purkinje cells by inactivating integrin signaling
Thu Jul 27 00:00:00 UTC 2017
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Nature medicine
Yokoi N,Fukata Y,Kase D,Miyazaki T,Jaegle M,Ohkawa T,Takahashi N,Iwanari H,Mochizuki Y,Hamakubo T,Imoto K,Meijer D,Watanabe M,Fukata M
MA1-046 was used in western blot to use mouse models to discover mechanisms that lead to LGI1-related epilepsy
Thu Jan 01 00:00:00 UTC 2015
Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade.
Proceedings of the National Academy of Sciences of the United States of America
Gainey MA,Tatavarty V,Nahmani M,Lin H,Turrigiano GG
MA1-046 was used in immunocytochemistry to examine receptor trafficking during synaptic scaling.
Tue Jul 07 00:00:00 UTC 2015
Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bacaj T,Ahmad M,Jurado S,Malenka RC,Südhof TC
MA1-046 was used in Immunocytochemistry to suggest a requirement for Rab11Fip5 and Rab11, during long-term depression.
Wed May 13 00:00:00 UTC 2015
Truncated tau deregulates synaptic markers in rat model for human tauopathy.
Frontiers in cellular neuroscience
Jadhav S,Katina S,Kovac A,Kazmerova Z,Novak M,Zilka N
MA1-046 was used in western blot to use of a rat model for human tauopathy to show that truncated tau deregulates synaptic markers
Tue Mar 10 00:00:00 UTC 2015
S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength.
Nature communications
Zhang P,Fu WY,Fu AK,Ip NY
MA1-046 was used in western blot to report that p35 S-nitrosylation by nitric oxide signaling regulates hippocampal synaptic strength
Tue Oct 27 00:00:00 UTC 2015
The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.
Molecular vision
Pak JS,Lee EJ,Craft CM
MA1-046 was used in immunohistochemistry to characterize Grk1 knock out mice with or without the Crb1(rd8) mutation
Fri Jun 24 00:00:00 UTC 2016
Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.
Scientific reports
Cho E,Kim DH,Hur YN,Whitcomb DJ,Regan P,Hong JH,Kim H,Ho Suh Y,Cho K,Park M
MA1-046 was used in western blot to characterize inhibition of plasticity-induced AMPA receptor exocytosis and LTP by Cyclin Y
Wed Jul 29 00:00:00 UTC 2015
Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.
Cell reports
Calafate S,Buist A,Miskiewicz K,Vijayan V,Daneels G,de Strooper B,de Wit J,Verstreken P,Moechars D
MA1-046 was used in immunohistochemistry to test if synaptic contacts between neurons aid propagation of Tau pathology.
Tue May 26 00:00:00 UTC 2015
Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum.
The Journal of biological chemistry
Russwurm C,Koesling D,Russwurm M
MA1-046 was used in western blot to investigate the effect of phosphorylation on the function of phosphodiesterase 10A.
Fri May 08 00:00:00 UTC 2015
LKB1 and AMPK regulate synaptic remodeling in old age.
Nature neuroscience
Samuel MA,Voinescu PE,Lilley BN,de Cabo R,Foretz M,Viollet B,Pawlyk B,Sandberg MA,Vavvas DG,Sanes JR
MA1-046 was used in Immunohistochemistry to find that the serine/threonine kinase LKB1 and AMPK, regulate age related decreases in neuronal function from synaptic remodelling.
Mon Sep 01 00:00:00 UTC 2014
Synaptic function of nicastrin in hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America
Lee SH,Sharma M,Südhof TC,Shen J
MA1-046 was used in western blot to test if presenilin and nicastrin regulate synaptic function in a gamma-secretase-dependent or -independent manner
Tue Jun 17 00:00:00 UTC 2014
Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ohkawa T,Satake S,Yokoi N,Miyazaki Y,Ohshita T,Sobue G,Takashima H,Watanabe O,Fukata Y,Fukata M
MA1-046 was used in immunocytochemistry to study the role of autoantibodies against the GABA(A) receptor to encephalitis
Wed Jun 11 00:00:00 UTC 2014
Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines.
Journal of neurochemistry
Yamazaki H,Kojima N,Kato K,Hirose E,Iwasaki T,Mizui T,Takahashi H,Hanamura K,Roppongi RT,Koibuchi N,Sekino Y,Mori N,Shirao T
MA1-046 was used in immunohistochemistry and western blot to study the regulation of dendritic spine morphology by the drebrin-binding protein spikar
Sat Feb 01 00:00:00 UTC 2014
DREAM controls the on/off switch of specific activity-dependent transcription pathways.
Molecular and cellular biology
Mellström B,Sahún I,Ruiz-Nuño A,Murtra P,Gomez-Villafuertes R,Savignac M,Oliveros JC,Gonzalez P,Kastanauskaite A,Knafo S,Zhuo M,Higuera-Matas A,Errington ML,Maldonado R,DeFelipe J,Jefferys JG,Bliss TV,Dierssen M,Naranjo JR
MA1-046 was used in western blot to study the role of DREAM in regulating activity-dependent transcription in the brain
Sat Mar 01 00:00:00 UTC 2014
N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo.
Hippocampus
Nikitczuk JS,Patil SB,Matikainen-Ankney BA,Scarpa J,Shapiro ML,Benson DL,Huntley GW
MA1-046 was used in immunohistochemistry and western blot to study the organization of adult hippocampal excitatory and inhibitory circuits and the role played by the N-cadherin/beta-catenin complex
Fri Aug 01 00:00:00 UTC 2014
Immunolocalization of the P2X4 receptor on neurons and glia in the mammalian retina.
Neuroscience
Ho T,Vessey KA,Fletcher EL
MA1-046 was used in western blot to determine the localization of the P2X4 receptor subunit in the retina
Fri Sep 26 00:00:00 UTC 2014
Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression.
The European journal of neuroscience
Dai X,Iwasaki H,Watanabe M,Okabe S
MA1-046 was used in immunocytochemistry to study the roles of neurophilin-2 and PAK3 in the mechanism by which Dlx1 modulates the growth and post-synaptic differentiation of dendritic cells
Sat Feb 01 00:00:00 UTC 2014
Sequential delivery of synaptic GluA1- and GluA4-containing AMPA receptors (AMPARs) by SAP97 anchored protein complexes in classical conditioning.
The Journal of biological chemistry
Zheng Z,Keifer J
MA1-046 was used in immunohistochemistry to study the role of SAP97 in the sequential delivery of synaptic GluA1 and GluA4 AMPAR subunits in classical conditioning
Fri Apr 11 00:00:00 UTC 2014
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation.
Nature neuroscience
Xu D,Shen W,Guo R,Xue Y,Peng W,Sima J,Yang J,Sharov A,Srikantan S,Yang J,Fox D,Qian Y,Martindale JL,Piao Y,Machamer J,Joshi SR,Mohanty S,Shaw AC,Lloyd TE,Brown GW,Ko MS,Gorospe M,Zou S,Wang W
MA1-046 was used in immunohistochemistry to study the interaction of human topoisomerase 3-beta with fragile X syndrome protein and its role in synapse formation
Sun Sep 01 00:00:00 UTC 2013
RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission.
Proceedings of the National Academy of Sciences of the United States of America
Schwechter B,Rosenmund C,Tolias KF
MA1-046 was used in immunocytochemistry to study the role of the Rac guanine nucleotide exchange activity of Ras GRF2 in the mechanism by which synaptic transmission is enhanced by NMDA calcium flux
Tue Aug 27 00:00:00 UTC 2013
Local palmitoylation cycles define activity-regulated postsynaptic subdomains.
The Journal of cell biology
Fukata Y,Dimitrov A,Boncompain G,Vielemeyer O,Perez F,Fukata M
MA1-046 was used in immunocytochemistry, immunohistochemistry - frozen section, and western blot to assess activity-regulated postsynaptic subdomains defined by local palmitoylation cycles
Mon Jul 08 00:00:00 UTC 2013
Transient, 5-HT2B receptor-mediated facilitation in neuropathic pain: Up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons.
Pain
Aira Z,Buesa I,García Del Caño G,Bilbao J,Doñate F,Zimmermann M,Azkue JJ
MA1-046 was used in immunohistochemistry and western blot to study the roles of PKCgamma and the NMDA receptor in 5-HT2B-mediated neuropathic pain facilitation
Sun Sep 01 00:00:00 UTC 2013
Super-resolution imaging reveals that AMPA receptors inside synapses are dynamically organized in nanodomains regulated by PSD95.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nair D,Hosy E,Petersen JD,Constals A,Giannone G,Choquet D,Sibarita JB
MA1-046 was used in immunocytochemistry to study the dynamic organization of AMPA receptors within synapses and the modulatory role of PSD95 using super-resolution imaging techniques
Wed Aug 07 00:00:00 UTC 2013
The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Duman JG,Tzeng CP,Tu YK,Munjal T,Schwechter B,Ho TS,Tolias KF
MA1-046 was used in Immunocytochemistry to identify brain-specific angiogenesis inhibitor 1 as a synaptic adhesion GPCR that is required for spinogenesis and synaptogenesis in mice and rats.
Wed Apr 17 00:00:00 UTC 2013
Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry.
The Journal of physiology
Kawahara A,Kurauchi S,Fukata Y,Martínez-Hernández J,Yagihashi T,Itadani Y,Sho R,Kajiyama T,Shinzato N,Narusuye K,Fukata M,Luján R,Shigemoto R,Ito I
MA1-046 was used in western blot to identify major histocompatibility complex class I as a regulator of asymmetry
Tue Oct 01 00:00:00 UTC 2013
Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT(2A) receptors.
Neuroscience letters
Roppongi RT,Kojima N,Hanamura K,Yamazaki H,Shirao T
MA1-046 was used in immunocytochemistry to study the ability of 5-HT(2A) receptor activation to reduce drebrin and F-actin levels in hippocampal neuron dendritic spines
Fri Jun 28 00:00:00 UTC 2013
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
The Journal of biological chemistry
Oku S,Takahashi N,Fukata Y,Fukata M
MA1-046 was used in immunohistochemistry and western blot to study neurochondrin targeting to Rab5-positive endosomes and the role of palmitoylation
Fri Jul 05 00:00:00 UTC 2013
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory.
Nature neuroscience
Lai KO,Wong AS,Cheung MC,Xu P,Liang Z,Lok KC,Xie H,Palko ME,Yung WH,Tessarollo L,Cheung ZH,Ip NY
MA1-046 was used in western blot to study Cdk5-mediated phosphorylation of the BDNF receptor TrkB and the role in activity-dependent structural plasticity and spatial memory
Thu Nov 01 00:00:00 UTC 2012
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
Science translational medicine
Sharma M,Burré J,Südhof TC
MA1-046 was used in immunohistochemistry to study the beneficial effects of proteasome inhibitors on neurodegeneration in a murine model of cysteine string protein-alpha deficiency
Wed Aug 15 00:00:00 UTC 2012
Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate.
Proceedings of the National Academy of Sciences of the United States of America
Irie F,Badie-Mahdavi H,Yamaguchi Y
MA1-046 was used in immunohistochemistry to characterize a transgenic mouse without heparan sulfate
Tue Mar 27 00:00:00 UTC 2012
Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Danglot L,Freret T,Le Roux N,Narboux Nême N,Burgo A,Hyenne V,Roumier A,Contremoulins V,Dauphin F,Bizot JC,Vodjdani G,Gaspar P,Boulouard M,Poncer JC,Galli T,Simmler MC
MA1-046 was used in immunohistochemistry to study the role of the membrane protein vezatin in dendritic spine morphogenesis and the functional maturation of synapses
Wed Jun 27 00:00:00 UTC 2012
PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gómez-Varela D,Schmidt M,Schoellerman J,Peters EC,Berg DK
MA1-046 was used in immunocytochemistry to study the mechanism by which plasma membrane calcium-ATPase pump isoform 2 controls calcium signaling in neurons
Wed May 16 00:00:00 UTC 2012
Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain.
ACS chemical neuroscience
Grünewald E,Tew KD,Porteous DJ,Thomson PA
MA1-046 was used in western blot to study the developmental and adult expression of GPCR50 in mouse brain and its potential role in neurotransmitter signaling
Wed Jun 20 00:00:00 UTC 2012
Sonic hedgehog regulates presynaptic terminal size, ultrastructure and function in hippocampal neurons.
Journal of cell science
Mitchell N,Petralia RS,Currier DG,Wang YX,Kim A,Mattson MP,Yao PJ
MA1-046 was used in Immunocytochemistry to examine whether Sonic hedgehog signalling has a function in hippocampal neurons.
Sat Sep 15 00:00:00 UTC 2012
Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons.
Molecular and cellular biology
Saba R,Störchel PH,Aksoy-Aksel A,Kepura F,Lippi G,Plant TD,Schratt GM
MA1-046 was used in Western Blotting to identify miRNAs that regulate synaptic plasticity within the nucleus accumbens, a brain region critical to forming drug-seeking habits.
Wed Feb 01 00:00:00 UTC 2012
Allopregnanolone prevents dieldrin-induced NMDA receptor internalization and neurotoxicity by preserving GABA(A) receptor function.
Endocrinology
Briz V,Parkash J,Sánchez-Redondo S,Prevot V,Suñol C
MA1-046 was used in western blot to study the mechanism for the effect of allopregnanolone on NMDA receptor internalization and neurotoxicity
Wed Feb 01 00:00:00 UTC 2012
Preso regulation of dendritic outgrowth through PI(4,5)P2-dependent PDZ interaction with βPix.
The European journal of neuroscience
Mo J,Lee D,Hong S,Han S,Yeo H,Sun W,Choi S,Kim H,Lee HW
MA1-046 was used in immunohistochemistry to study the role of the PI(4,5)P2-dependent interaction of PDZ with beta-Pix in the regulation of dendritic outgrowth by Preso
Sun Jul 01 00:00:00 UTC 2012
Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation.
Brain research
Pichardo-Casas I,Goff LA,Swerdel MR,Athie A,Davila J,Ramos-Brossier M,Lapid-Volosin M,Friedman WJ,Hart RP,Vaca L
MA1-046 was used in western blot to characterize the expression profile of synaptoneurosomal miRNAs in different regions of the rat brain and the corresponding change due to prolonged excitatory stimulation
Fri Feb 03 00:00:00 UTC 2012
Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain.
The Journal of comparative neurology
Noam Y,Phan L,McClelland S,Manders EM,Ehrengruber MU,Wadman WJ,Baram TZ,Chen Y
MA1-046 was used in immunohistochemistry to study filamin A and its anatomical and subcellular localization in the brain of mature rats
Sat Sep 01 00:00:00 UTC 2012
Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons.
The Journal of biological chemistry
Mori Y,Matsui T,Furutani Y,Yoshihara Y,Fukuda M
MA1-046 was used in immunocytochemistry to investigate the effect of small GTPase Rab17 on the dentritic morphogenesis and postsynaptic development of hippocampal neurons
Fri Mar 16 00:00:00 UTC 2012
Cofilin aggregation blocks intracellular trafficking and induces synaptic loss in hippocampal neurons.
The Journal of biological chemistry
Cichon J,Sun C,Chen B,Jiang M,Chen XA,Sun Y,Wang Y,Chen G
MA1-046 was used in immunohistochemistry to investigate the role of cofilin in hippocampal neurons
Fri Feb 03 00:00:00 UTC 2012
Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse.
PloS one
Vessey KA,Fletcher EL
MA1-046 was used in Immunohistochemistry to determine if the P2X7 receptor has a role in mediating neurotransmission in the central nervous system, using the P2X7 receptor knock-out mouse.
Tue May 29 00:00:00 UTC 2012
Identification of a novel signaling pathway and its relevance for GluA1 recycling.
PloS one
Seebohm G,Neumann S,Theiss C,Novkovic T,Hill EV,Tavaré JM,Lang F,Hollmann M,Manahan-Vaughan D,Strutz-Seebohm N
MA1-046 was used in immunocytochemistry to study a novel signaling pathway involved in recycling the AMPA-type glutamate receptor GluA1
Fri Aug 03 00:00:00 UTC 2012
Ca2+-activated Cl− currents are dispensable for olfaction.
Nature neuroscience
Billig GM,Pál B,Fidzinski P,Jentsch TJ
MA1-046 was used in immunohistochemistry to investigate the involvement of calcium-activated chloride channels in olfaction
Wed Jun 01 00:00:00 UTC 2011
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins.
Proceedings of the National Academy of Sciences of the United States of America
Bolliger MF,Martinelli DC,Südhof TC
MA1-046 was used in immunocytochemistry to identify the receptor for C1q-like proteins
Tue Feb 08 00:00:00 UTC 2011
Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons.
The Journal of cell biology
Ko J,Soler-Llavina GJ,Fuccillo MV,Malenka RC,Südhof TC
MA1-046 was used in immunocytochemistry to investigate the effect of decreased expression levels of neuroligins and leucine-rich repeat transmembrane proteins on cultured hippocampal neurons
Mon Jul 25 00:00:00 UTC 2011
PSD-95 alters microtubule dynamics via an association with EB3.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sweet ES,Previtera ML,Fernández JR,Charych EI,Tseng CY,Kwon M,Starovoytov V,Zheng JQ,Firestein BL
MA1-046 was used in immunocytochemistry to investigate the mechanism for cytoskeleton changes mediated by PSD95
Wed Jan 19 00:00:00 UTC 2011
PSD-95 and PSD-93 play critical but distinct roles in synaptic scaling up and down.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sun Q,Turrigiano GG
MA1-046 was used in immunocytochemistry to investigate the role of PSD-95 in synaptic scaling
Wed May 04 00:00:00 UTC 2011
Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tapia L,Milnerwood A,Guo A,Mills F,Yoshida E,Vasuta C,Mackenzie IR,Raymond L,Cynader M,Jia W,Bamji SX
MA1-046 was used in immunohistochemistry to investigate the role of progranulin for the regulation of synaptic function in vitro
Wed Aug 03 00:00:00 UTC 2011
cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain.
Journal of neurochemistry
Yang HB,Yang X,Cao J,Li S,Liu YN,Suo ZW,Cui HB,Guo Z,Hu XD
MA1-046 was used in immunohistochemistry to demonstrate the colocalization of GluN2B with post-synaptic density marker PSD-95
Sat Jan 01 00:00:00 UTC 2011
Ultrastructural modifications of spine and synapse morphology by SAP97.
Hippocampus
Poglia L,Muller D,Nikonenko I
MA1-046 was used in immunohistochemistry to study the effect of SAP97 on the morphology of spine and synapse of rat pyramidal neurons in hippocampal slice cultures
Thu Sep 01 00:00:00 UTC 2011
Cell-type-specific localization of protocadherin β16 at AMPA and AMPA/Kainate receptor-containing synapses in the primate retina.
The Journal of comparative neurology
Puller C,Haverkamp S
MA1-046 was used in immunohistochemistry to investigate the expression of protocadherins in glutamatergic synapses
Tue Feb 15 00:00:00 UTC 2011
Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the γ-Protocadherins.
Frontiers in molecular neuroscience
Prasad T,Weiner JA
MA1-046 was used in immunohistochemistry to study the role of protocadherins in the development of spinal cord afferent circuit
Tue Oct 02 00:00:00 UTC 2012
N-cadherin and neuroligins cooperate to regulate synapse formation in hippocampal cultures.
The Journal of biological chemistry
Aiga M,Levinson JN,Bamji SX
MA1-046 was used in immunohistochemistry to investigate the role of N-cadherin and neuroligins in synapse formation
Fri Jan 07 00:00:00 UTC 2011
Cellular mechanisms for dopamine D4 receptor-induced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
The Journal of biological chemistry
Yuen EY,Yan Z
MA1-046 was used in immunocytochemistry to investigate the regulation of AMPA receptors by dopamine D4 receptor
Fri Jul 15 00:00:00 UTC 2011
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons.
Nature neuroscience
Chang MC,Park JM,Pelkey KA,Grabenstatter HL,Xu D,Linden DJ,Sutula TP,McBain CJ,Worley PF
MA1-046 was used in immunocytochemistry to study the role of the immediate-early gene Narp in regulating homeostatic scaling of excitatory synapses
Wed Sep 01 00:00:00 UTC 2010
Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling.
Proceedings of the National Academy of Sciences of the United States of America
McClelland AC,Hruska M,Coenen AJ,Henkemeyer M,Dalva MB
MA1-046 was used in immunocytochemistry to investigate the mechanism of excitatory synapse density modulation by EphB2-ephrin-B3 association
Tue May 11 00:00:00 UTC 2010
AMPA and metabotropic excitoxicity explain subplate neuron vulnerability.
Neurobiology of disease
Nguyen V,McQuillen PS
MA1-046 was used in immunocytochemistry to investigate the mechanism for subplate neuron vulnerability during cerebral hypoxia-ischemia
Fri Jan 01 00:00:00 UTC 2010
PAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarization.
Development (Cambridge, England)
Achilleos A,Wehman AM,Nance J
MA1-046 was used in immunohistochemistry to investigate the cellular role of PAR-3 during C. elegans intestinal epithelial cell polarization
Tue Jun 01 00:00:00 UTC 2010
Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mah W,Ko J,Nam J,Han K,Chung WS,Kim E
MA1-046 was used in immunocytochemistry to investigate the role of SALM proteins in the process of synapse formation
Wed Apr 21 00:00:00 UTC 2010
Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen LY,Rex CS,Babayan AH,Kramár EA,Lynch G,Gall CM,Lauterborn JC
MA1-046 was used in immunohistochemistry to investigate the Rac>PAK signaling pathway in a Fmr1-knockout mouse model
Wed Aug 18 00:00:00 UTC 2010
Tumor necrosis factor-α signaling maintains the ability of cortical synapses to express synaptic scaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Steinmetz CC,Turrigiano GG
MA1-046 was used in immunocytochemistry to investigate the role of tumor necrosis factor-alpha for the ability of cortical synapses to express synaptic scaling
Wed Nov 03 00:00:00 UTC 2010
Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption.
Experimental neurology
Lim Y,Kehm VM,Li C,Trojanowski JQ,Lee VM
MA1-046 was used in western blot to investigate the effect of alpha-syn overexpression on the degeneration of developing neurons
Fri Jan 01 00:00:00 UTC 2010
Cannabinoid receptor activation reduces TNFalpha-induced surface localization of AMPAR-type glutamate receptors and excitotoxicity.
Neuropharmacology
Zhao P,Leonoudakis D,Abood ME,Beattie EC
MA1-046 was used in immunocytochemistry to investigate the influence of cannabinoid receptor function on AMPAR-type glutamate receptor distribution
Mon Feb 01 00:00:00 UTC 2010
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
Molecular and cellular neurosciences
Tian X,Kai L,Hockberger PE,Wokosin DL,Surmeier DJ
MA1-046 was used in immunocytochemistry to identify homeostatic mechanisms underlying striatal adaptations in Parkinson disease
Sat May 01 00:00:00 UTC 2010
Synaptic localization of neuroligin 2 in the rodent retina: comparative study with the dystroglycan-containing complex.
Journal of neuroscience research
Lui L,Levinson JN,Noël G,Handrigan GR,Richman JM,El-Husseini A,Moukhles H
MA1-046 was used in immunohistochemistry to determine the localization of neuroligin 2 in rodent retinal synapses
Mon Mar 01 00:00:00 UTC 2010
Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood.
Neuroscience
Kojima N,Hanamura K,Yamazaki H,Ikeda T,Itohara S,Shirao T
MA1-046 was used in western blot to compare the role of drebrin in neuronal function and cognitive process
Wed Jan 13 00:00:00 UTC 2010
Low accumulation of drebrin at glutamatergic postsynaptic sites on GABAergic neurons.
Neuroscience
Hanamura K,Mizui T,Kakizaki T,Roppongi RT,Yamazaki H,Yanagawa Y,Shirao T
MA1-046 was used in immunocytochemistry to investigate the level of drebin in GABAergic neurons
Wed Sep 15 00:00:00 UTC 2010
Organization of NMDA receptors at extrasynaptic locations.
Neuroscience
Petralia RS,Wang YX,Hua F,Yi Z,Zhou A,Ge L,Stephenson FA,Wenthold RJ
MA1-046 was used in immunocytochemistry to study the extrasynaptic localization of NMDA receptors and its involvement in the synaptic formation
Wed Apr 28 00:00:00 UTC 2010
Immunohistochemical evidence for synaptic release of glutamate from orexin terminals in the locus coeruleus.
Neuroscience
Henny P,Brischoux F,Mainville L,Stroh T,Jones BE
MA1-046 was used in immunohistochemistry to investigate the location of glutamate synaptic release in the locus coeruleus
Wed Sep 01 00:00:00 UTC 2010
Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses.
The Journal of comparative neurology
Su J,Gorse K,Ramirez F,Fox MA
MA1-046 was used in western blot to investigate the effect of collagen XIX on the formation of hippocampal synapses
Sun Jan 10 00:00:00 UTC 2010
Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb.
The Journal of comparative neurology
Lepousez G,Csaba Z,Bernard V,Loudes C,Videau C,Lacombe J,Epelbaum J,Viollet C
MA1-046 was used in immunocytochemistry to study the presence of somatostatin interneurons in the external plexiform layer in the mouse main olfactory bulb
Tue Jun 01 00:00:00 UTC 2010
DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory.
Molecular brain
Wu LJ,Mellström B,Wang H,Ren M,Domingo S,Kim SS,Li XY,Chen T,Naranjo JR,Zhuo M
MA1-046 was used in immunoprecipitation to study the role of downstream regulatory element antagonist modulator in synaptic depression and fear formation
Thu Jan 21 00:00:00 UTC 2010
Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Huang K,Sanders S,Singaraja R,Orban P,Cijsouw T,Arstikaitis P,Yanai A,Hayden MR,El-Husseini A
MA1-046 was used in western blot to study the substrate specificity of four neuronal palmitoyl acyl transferases
Sat Aug 01 00:00:00 UTC 2009
Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis.
Journal of cell science
Takahashi H,Yamazaki H,Hanamura K,Sekino Y,Shirao T
MA1-046 was used in immunocytochemistry to study the role of the AMPA receptor in dendritic spine morphogenesis
Wed Apr 15 00:00:00 UTC 2009
Role of PSD95 in membrane association and catalytic activity of nNOSalpha in nitrergic varicosities in mice gut.
American journal of physiology. Gastrointestinal and liver physiology
Chaudhury A,He XD,Goyal RK
MA1-046 was used in immunoprecipitation and western blot to study the role of PSD95 in membrane association and catalytic activity of nNOSalpha in nitrergic varicosities in mouse gut
Thu Oct 01 00:00:00 UTC 2009
GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth.
Molecular and cellular neurosciences
Grünewald E,Kinnell HL,Porteous DJ,Thomson PA
MA1-046 was used in western blot to study the interaction between GPR50 and NOGO-A and its effect on neurite outgrowth
Tue Dec 01 00:00:00 UTC 2009
Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal.
Toxicology and applied pharmacology
Pitt J,Roth W,Lacor P,Smith AB,Blankenship M,Velasco P,De Felice F,Breslin P,Klein WL
MA1-046 was used in Immunocytochemistry to suggest that oleocanthal is capable of altering the oligomerisation state of ADDLs while protecting neurons from the synaptopathological effects of ADDLs.
Thu Oct 15 00:00:00 UTC 2009
Imaging synaptogenesis by measuring accumulation of synaptic proteins.
Cold Spring Harbor protocols
Dean C,Scheiffele P
MA1-046 was used in immunocytochemistry to develop a procedure for imaging synaptogenesis by measuring accumulation of synaptic proteins
Sun Nov 01 00:00:00 UTC 2009
Organization of the core structure of the postsynaptic density.
Proceedings of the National Academy of Sciences of the United States of America
Chen X,Winters C,Azzam R,Li X,Galbraith JA,Leapman RD,Reese TS
MA1-046 was used in western blot to investigate the molecular organization of postsynaptic density at glutamatergic synapses.
Tue Mar 18 00:00:00 UTC 2008
Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Luikart BW,Zhang W,Wayman GA,Kwon CH,Westbrook GL,Parada LF
MA1-046 was used in immunocytochemistry to study the molecular pathways underlying dendritic filopodial motility and synaptic formation.
Wed Jul 02 00:00:00 UTC 2008
Subunit-specific surface mobility of differentially labeled AMPA receptor subunits.
European journal of cell biology
Kropf M,Rey G,Glauser L,Kulangara K,Johnsson K,Hirling H
MA1-046 was used in immunohistochemistry to study the lateral mobility and trafficing of differentially labeled AMPA receptor subunits
Wed Oct 01 00:00:00 UTC 2008
Treadmill training after spinal cord hemisection in mice promotes axonal sprouting and synapse formation and improves motor recovery.
Journal of neurotrauma
Goldshmit Y,Lythgo N,Galea MP,Turnley AM
MA1-046 was used in immunohistochemistry to study the effect of treadmill training on axonal regrowth and functional recovery after spinal cord injury in mice
Thu May 01 00:00:00 UTC 2008
Localization and possible function of P2Y(4) receptors in the rodent retina.
Neuroscience
Ward MM,Puthussery T,Fletcher EL
MA1-046 was used in immunohistochemistry to study the localization and role of P2Y(4) receptors in rodent retina
Tue Sep 09 00:00:00 UTC 2008
New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kato AS,Zhou W,Milstein AD,Knierman MD,Siuda ER,Dotzlaf JE,Yu H,Hale JE,Nisenbaum ES,Nicoll RA,Bredt DS
MA1-046 was used in immunoprecipitation to characterize a new member of the TARP family and its effect on AMPA receptors in cerebellar neurons.
Wed May 02 00:00:00 UTC 2007
Expression of alpha 7 nicotinic acetylcholine receptors by bipolar, amacrine, and ganglion cells of the rabbit retina.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Dmitrieva NA,Strang CE,Keyser KT
MA1-046 was used in immunohistochemistry to study the expression level of alpha 7 nAChRs in rabbit retinal neurons
Tue May 01 00:00:00 UTC 2007
Regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneurons.
Brain research bulletin
Longart M,Chatani-Hinze M,Gonzalez CM,Vullhorst D,Buonanno A
MA1-046 was used in immunocytochemistry to study the role of neuregulin in modulating ErbB4 endocytosis in cultured hippocampal neurons
Thu Jul 12 00:00:00 UTC 2007
Composition of the synaptic PSD-95 complex.
Molecular & cellular proteomics : MCP
Dosemeci A,Makusky AJ,Jankowska-Stephens E,Yang X,Slotta DJ,Markey SP
MA1-046 was used in immunoprecipitation to identify the major constituent proteins of the synaptic PSD-95 complex.
Mon Oct 01 00:00:00 UTC 2007
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.
Cell
Offenhäuser N,Castelletti D,Mapelli L,Soppo BE,Regondi MC,Rossi P,D'Angelo E,Frassoni C,Amadeo A,Tocchetti A,Pozzi B,Disanza A,Guarnieri D,Betsholtz C,Scita G,Heberlein U,Di Fiore PP
MA1-046 was used in western blot to study the role of altered actin dynamics in increased ethanol resistance and consumption in Eps8 knockout mice
Fri Oct 06 00:00:00 UTC 2006
BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactions.
The Journal of cell biology
Bamji SX,Rico B,Kimes N,Reichardt LF
MA1-046 was used in immunohistochemistry to investigate the effect of brain-derived neurotrophic factor on the synaptic vesicle mobilization and the synapse formation.
Mon Jul 17 00:00:00 UTC 2006
Telencephalin slows spine maturation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Matsuno H,Okabe S,Mishina M,Yanagida T,Mori K,Yoshihara Y
MA1-046 was used in immunocytochemistry to study the role of the adhesion molecule telencephalin in slowing spine maturation
Wed Feb 08 00:00:00 UTC 2006
Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons.
Molecular pharmacology
Gu Z,Jiang Q,Yuen EY,Yan Z
MA1-046 was used in immunocytochemistry to investigate the subcellular localization of CaMKII influenced by D4 receptor activation in cultured prefrontal cortical neurons
Wed Mar 01 00:00:00 UTC 2006
Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retina.
The European journal of neuroscience
Bahadori R,Biehlmaier O,Zeitz C,Labhart T,Makhankov YV,Forster U,Gesemann M,Berger W,Neuhauss SC
MA1-046 was used in immunohistochemistry to study the role of nyctalopin in synaptic transmission in the zebrafish retina
Fri Sep 01 00:00:00 UTC 2006
Evidence for the involvement of purinergic P2X receptors in outer retinal processing.
The European journal of neuroscience
Puthussery T,Yee P,Vingrys AJ,Fletcher EL
MA1-046 was used in immunohistochemistry to investigate the association between extracellular purines and outer retinal processing
Sat Jul 01 00:00:00 UTC 2006
Preparation of postsynaptic density fraction from hippocampal slices and proteomic analysis.
Biochemical and biophysical research communications
Dosemeci A,Tao-Cheng JH,Vinade L,Jaffe H
MA1-046 was used in blocking or activating experiment to establish a method for the preparation of postsynaptic density fractions from hippocampal slices
Fri Jan 13 00:00:00 UTC 2006
Mosaic deletion of Rb arrests rod differentiation and stimulates ectopic synaptogenesis in the mouse retina.
The Journal of comparative neurology
Johnson DA,Donovan SL,Dyer MA
MA1-046 was used in immunohistochemistry to study the role of the retinoblastoma gene in rod differentiation and ectopic synaptogenesis in murine retina
Fri Sep 01 00:00:00 UTC 2006
AII amacrine cells in the distal inner nuclear layer of the mouse retina.
The Journal of comparative neurology
Lee EJ,Mann LB,Rickman DW,Lim EJ,Chun MH,Grzywacz NM
MA1-046 was used in immunocytochemistry to identify and characterize misplaced AII amacrine cells in the distal inner nuclear layer of mouse retina
Wed Feb 01 00:00:00 UTC 2006
Involvement of myosin Vb in glutamate receptor trafficking.
The Journal of biological chemistry
Lisé MF,Wong TP,Trinh A,Hines RM,Liu L,Kang R,Hines DJ,Lu J,Goldenring JR,Wang YT,El-Husseini A
MA1-046 was used in immunocytochemistry to reveal the role of myosin Vb in glutamate receptor trafficking.
Fri Feb 10 00:00:00 UTC 2006
Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter.
Proceedings of the National Academy of Sciences of the United States of America
Nam CI,Chen L
MA1-046 was used in immunocytochemistry to investigate the role of presynaptic beta-neurexins in regulating postsynaptic differentiation.
Tue Apr 26 00:00:00 UTC 2005
The origin recognition core complex regulates dendrite and spine development in postmitotic neurons.
The Journal of cell biology
Huang Z,Zang K,Reichardt LF
MA1-046 was used in immunohistochemistry to study the role of the origin recognition core complex in regulating dendrite and spine development of postmitotic neurons
Mon Aug 15 00:00:00 UTC 2005
Molecular constituents of neuronal AMPA receptors.
The Journal of cell biology
Fukata Y,Tzingounis AV,Trinidad JC,Fukata M,Burlingame AL,Nicoll RA,Bredt DS
MA1-046 was used in western blot to identify stargazin-like transmembrane AMPAR regulatory proteins as a part of neuronal alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
Mon May 09 00:00:00 UTC 2005
Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post-synaptic densities following transient global ischemia in the rat brain.
Journal of neurochemistry
Besshoh S,Bawa D,Teves L,Wallace MC,Gurd JW
MA1-046 was used in western blot to study the involvement of lipid rafts in increased phosphorylation of NMDA receptors after transient global ischemia in the rat brain
Fri Apr 01 00:00:00 UTC 2005
Direct interaction of myosin regulatory light chain with the NMDA receptor.
Journal of neurochemistry
Amparan D,Avram D,Thomas CG,Lindahl MG,Yang J,Bajaj G,Ishmael JE
MA1-046 was used in immunohistochemistry to study the interaction between myosin regulatory light chain and the NMDA receptor
Sat Jan 01 00:00:00 UTC 2005
Association of heat shock proteins and neuronal membrane components with lipid rafts from the rat brain.
Journal of neuroscience research
Chen S,Bawa D,Besshoh S,Gurd JW,Brown IR
MA1-046 was used in western blot to investigate the role of heat short proteins in lipid raft-associated signal transduction process
Mon Aug 15 00:00:00 UTC 2005
The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner.
The European journal of neuroscience
Neuhoff H,Sassoè-Pognetto M,Panzanelli P,Maas C,Witke W,Kneussel M
MA1-046 was used in immunohistochemistry to study the subcellular expression of profilin I in brain neurons and its potential role in activity-dependent synaptic structure remodelling
Sat Jan 01 00:00:00 UTC 2005
Collagen XVII and BPAG1 expression in the retina: evidence for an anchoring complex in the central nervous system.
The Journal of comparative neurology
Claudepierre T,Manglapus MK,Marengi N,Radner S,Champliaud MF,Tasanen K,Bruckner-Tuderman L,Hunter DD,Brunken WJ
MA1-046 was used in immunohistochemistry to study the expression of collagen XVII and BPAG-1 in the retina
Mon Jun 27 00:00:00 UTC 2005
Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity.
The Journal of biological chemistry
Levinson JN,Chéry N,Huang K,Wong TP,Gerrow K,Kang R,Prange O,Wang YT,El-Husseini A
MA1-046 was used in immunocytochemistry to study the role for neuroligins and their synaptic partners in controlling the number of inhibitory and excitatory synapses.
Fri Apr 29 00:00:00 UTC 2005
A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin.
Proceedings of the National Academy of Sciences of the United States of America
Prange O,Wong TP,Gerrow K,Wang YT,El-Husseini A
MA1-046 was used in immunocytochemistry to study the role of PSD-95 and neuroligin during the excitatory and inhibitory synapse formation.
Tue Sep 21 00:00:00 UTC 2004
Postsynaptic density assembly is fundamentally different from presynaptic active zone assembly.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bresler T,Shapira M,Boeckers T,Dresbach T,Futter M,Garner CC,Rosenblum K,Gundelfinger ED,Ziv NE
MA1-046 was used in immunohistochemistry to examine the recruitment of PSD molecules, NMDA receptor subunit NR1, and the scaffolding molecules ProSAP1 and ProSAP2 to nascent synaptic junctions.
Wed Feb 11 00:00:00 UTC 2004
PSD93 regulates synaptic stability at neuronal cholinergic synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Parker MJ,Zhao S,Bredt DS,Sanes JR,Feng G
MA1-046 was used in Binding experiments to examine the assembly of the postsynaptic complex of neuronal cholinergic synapses.
Wed Jan 14 00:00:00 UTC 2004
Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase.
Neuroscience
Fleisig H,El-Din El-Husseini A,Vincent SR
MA1-046 was used in immunocytochemistry to investigate the regulatory effect of ACPT on ErbB4 phosphorylation and cleavage
Thu Oct 14 00:00:00 UTC 2004
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.
Neuron
Colledge M,Snyder EM,Crozier RA,Soderling JA,Jin Y,Langeberg LK,Lu H,Bear MF,Scott JD
MA1-046 was used in immunocytochemistry to investigate the role of ubiquitination for PSD-95 degradation and AMPA receptor surface expression
Thu Oct 30 00:00:00 UTC 2003
Role of beta-catenin in synaptic vesicle localization and presynaptic assembly.
Neuron
Bamji SX,Shimazu K,Kimes N,Huelsken J,Birchmeier W,Lu B,Reichardt LF
MA1-046 was used in immunohistochemistry to study the role of beta-catenin in synaptic organization
Thu Nov 13 00:00:00 UTC 2003
Distribution of postsynaptic density (PSD)-95 and Ca2+/calmodulin-dependent protein kinase II at the PSD.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Petersen JD,Chen X,Vinade L,Dosemeci A,Lisman JE,Reese TS
MA1-046 was used in immunocytochemistry to investigate the localization of postsynaptic density (PSD)-95 at the PSD
Wed Dec 03 00:00:00 UTC 2003
Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Takahashi H,Sekino Y,Tanaka S,Mizui T,Kishi S,Shirao T
MA1-046 was used in immunocytochemistry to investigate the role of drebrin synaptic clustering during neuronal development and spine morphogenesis.
Wed Jul 23 00:00:00 UTC 2003
Cellular localization of the MPP4 protein in the mammalian retina.
Investigative ophthalmology & visual science
Stöhr H,Stojic J,Weber BH
MA1-046 was used in immunocytochemistry to examine the distribution of MPP4 in mammalian retina
Mon Dec 01 00:00:00 UTC 2003
Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins.
The Biochemical journal
Larsson M,Hjälm G,Sakwe AM,Engström A,Höglund AS,Larsson E,Robinson RC,Sundberg C,Rask L
MA1-046 was used in immunoprecipitation to characterize the interaction of megalin with MAGUK proteins
Tue Jul 15 00:00:00 UTC 2003
Gamma protocadherins are required for survival of spinal interneurons.
Neuron
Wang X,Weiner JA,Levi S,Craig AM,Bradley A,Sanes JR
MA1-046 was used in immunohistochemistry to study the role of gamma protocadherins in the survival of spinal interneurons
Thu Dec 05 00:00:00 UTC 2002
Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.
Neuron
Elgersma Y,Fedorov NB,Ikonen S,Choi ES,Elgersma M,Carvalho OM,Giese KP,Silva AJ
MA1-046 was used in western blot to study the role of CaMKII inhibitory autophosphorylation in hippocampal plasticity and learning
Thu Oct 24 00:00:00 UTC 2002
Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure.
Proceedings of the National Academy of Sciences of the United States of America
Weber BH,Schrewe H,Molday LL,Gehrig A,White KL,Seeliger MW,Jaissle GB,Friedburg C,Tamm E,Molday RS
MA1-046 was used in immunohistochemistry to study the function of the retinoschisin protein and its role in X-linked juvenile retinoschisis.
Tue Apr 30 00:00:00 UTC 2002
Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97.
The European journal of neuroscience
Klöcker N,Bunn RC,Schnell E,Caruana G,Bernstein A,Nicoll RA,Bredt DS
MA1-046 was used in immunocytochemistry to study the effects on cellular distribution, protein clustering and synaptic structure of SAP97 lacking the SH3 and GK domains
Tue Oct 01 00:00:00 UTC 2002
Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel.
The Journal of biological chemistry
Imamura F,Maeda S,Doi T,Fujiyoshi Y
MA1-046 was used in immunocytochemistry to investigate the mechanism for the regulation of PSD-95 clustering.
Fri Feb 01 00:00:00 UTC 2002
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms.
Nature
Chen L,Chetkovich DM,Petralia RS,Sweeney NT,Kawasaki Y,Wenthold RJ,Bredt DS,Nicoll RA
MA1-046 was used in western blot to study the mechanisms by which stargazin regulates synaptic targeting of AMPA receptors
Thu Jan 25 00:00:00 UTC 2001
Glutamate-induced transient modification of the postsynaptic density.
Proceedings of the National Academy of Sciences of the United States of America
Dosemeci A,Tao-Cheng JH,Vinade L,Winters CA,Pozzo-Miller L,Reese TS
MA1-046 was used in immunocytochemistry to investigate the mechanism of the transient modification of the postsynaptic density induced by glutamate.
Tue Aug 28 00:00:00 UTC 2001
Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sans N,Racca C,Petralia RS,Wang YX,McCallum J,Wenthold RJ
MA1-046 was used in immunoprecipitation to investigate the interaction between GluR1 and SAP97.
Mon Oct 01 00:00:00 UTC 2001
A sequence motif responsible for ER export and surface expression of Kir2.0 inward rectifier K(+) channels.
FEBS letters
Stockklausner C,Ludwig J,Ruppersberg JP,Klöcker N
MA1-046 was used in immunocytochemistry to investigate the secretory pathway for and surface expression of Kir2.0 inward rectifier potassium channels
Fri Mar 30 00:00:00 UTC 2001
Sustained elevation of calcium induces Ca(2+)/calmodulin-dependent protein kinase II clusters in hippocampal neurons.
Neuroscience
Tao-Cheng JH,Vinade L,Smith C,Winters CA,Ward R,Brightman MW,Reese TS,Dosemeci A
MA1-046 was used in immunohistochemistry to investigate the effect of calcium elevation on calcium/calmodulin-dependent protein kinase II clusters in hippocampal neurons
Tue Dec 04 00:00:00 UTC 2001
Blockade of cadherin-6B activity perturbs the distribution of PSD-95 family proteins in retinal neurones.
Genes to cells : devoted to molecular & cellular mechanisms
Honjo Y,Nakagawa S,Takeichi M
MA1-046 was used in immunocytochemistry to investigate the role of cadherins in synaptic organization
Sat Apr 01 00:00:00 UTC 2000
Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang W,Vazquez L,Apperson M,Kennedy MB
MA1-046 was used in western blot to investigate the interaction between citron and PSD-95 at synapses
Fri Jan 01 00:00:00 UTC 1999
PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain.
The Journal of biological chemistry
Christopherson KS,Hillier BJ,Lim WA,Bredt DS
MA1-046 was used in western blot to study the formation of a postsynaptic protein complex containning PSD-95, nNOS and NMDA receptors
Fri Sep 24 00:00:00 UTC 1999
Immunocytochemical localization of the postsynaptic density protein PSD-95 in the mammalian retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Koulen P,Fletcher EL,Craven SE,Bredt DS,Wässle H
MA1-046 was used in immunocytochemistry to locate the postsynaptic density protein PSD-95 in the mammalian retina
Tue Dec 01 00:00:00 UTC 1998
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.
Science (New York, N.Y.)
Kornau HC,Schenker LT,Kennedy MB,Seeburg PH
MA1-046 was used in western blot to investigate the interaction between NMDA and PSD-95
Fri Sep 22 00:00:00 UTC 1995
