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Proteintech
PSMA/GCPII Monoclonal Antibody (3G4E12)
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Product Details
66678-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3G4E12
Immunogen
PSMA/GCPII Fusion Protein Ag16594 (45-385 aa encoded by BC025672)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SSNEATNIT PKHNMKAFLD ELKAENIKKF LYNFTQIPHL AGTEQNFQLA KQIQSQWKEF GLDSVELAHY DVLLSYPNKT HPNYISIINE DGNEIFNTSL FEPPPPGYEN VSDIVPPFSA FSPQGMPEGD LVYVNYARTE DFFKLERDMK INCSGKIVIA RYGKVFRGNK VKNAQLAGAK GVILYSDPAD YFAPGVKSYP DGWNLPGGGV QRGNILNLNG AGDPLTPGYP ANEYAYRRGI AEAVGLPSIP VHPIGYYDAQ KLLEKMGGSA PPDSSWRGSL KVPYNVGPGF TGNFSTQKVK MHIHSTNEVT RIYNVIGTLR GAVEPDRYVI LGGHRDSWVF GG (45-385 aa encoded by BC025672)
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cell growth-inhibiting gene 27 protein; FGCP; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; GCPII; glutamate carboxylase II; Glutamate carboxypeptidase 2; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; mGCP; N-acetylated alpha-linked acidic dipeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; prostate specific membrane antigen; prostate specific membrane antigen variant F; Prostate-specific membrane antigen; Prostate-specific membrane antigen homolog; PSM; Pteroylpoly-gamma-glutamate carboxypeptidase
Gene Aliases: FGCP; FOLH; FOLH1; GCP2; GCPII; GIG27; mGCP; Naalad; NAALAD1; NAALAdase; PSM; PSMA
UniProt ID: (Human) Q04609, (Rat) P70627
Entrez Gene ID: (Human) 2346, (Rat) 85309
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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