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Invitrogen
PSMA8 Polyclonal Antibody
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FIGURE: 1 / 1
PSMA8 Antibody (PA5-89783) in WB
Western blot analysis of PSMA8 in extracts of various cell lines. Samples were incubated with PSMA8 Polyclonal antibody (Product # PA5-89783) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-89783
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PSMA8 (NP_6532632)
Conjugate
Form
Liquid
Concentration
2.33 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805773
Product Specific Information
Immunogen sequence: MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ SHKLTVEDPV TVEYITRFIA TLKQKYTQSN GRRPFGISAL IVGFDDDGIS RLYQTDPSGT YHAWKANAIG RSAKTVREFL EKNYTEDAIA SDSEAIKLAI KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI; Positive Samples: K-562, Mouse thymus, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Nucleus
Target Information
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complexe that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha4s; proteasome (prosome, macropain) subunit, alpha type, 8; Proteasome alpha 4 subunit; proteasome alpha 8 subunit; proteasome subunit alpha type 7-like protein variant 1; proteasome subunit alpha type-7-like; Proteasome subunit alpha type-8; Proteasome subunit alpha-type 7-like; Proteasome subunit alpha-type 8
Gene Aliases: 2410072D24Rik; PSMA7L; PSMA8; RGD1311659
UniProt ID: (Human) Q8TAA3, (Mouse) Q9CWH6
Entrez Gene ID: (Human) 143471, (Mouse) 73677, (Rat) 364814
proteolysis
ubiquitin-dependent protein catabolic process
proteasomal ubiquitin-independent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
proteolysis involved in cellular protein catabolic process
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
regulation of mRNA stability
T cell receptor signaling pathway
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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