Proteintech

PSMB1 Polyclonal Antibody

PSMB1 Antibody in Immunocytochemistry (ICC/IF)

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PSMB1 Antibody (11749-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed U2OS cells using (Product # 11749-1-AP) (PSMB1 antibody), at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Red stain with CL594-Phalloidin. Blue stain with DAPI.

PSMB1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11749-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PSMB1 Fusion Protein Ag2345 (1-241 aa encoded by BC020807)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLSSTAMYS APGRDLGMEP HRAAGPLQLR FSPYVFNGGT ILAIAGEDFA IVASDTRLSE GFSIHTRDSP KCYKLTDKTV IGCSGFHGDC LTLTKIIEAR LKMYKHSNNK AMTTGAIAAM LSTILYSRRF FPYYVYNIIG GLDEEGKGAV YSFDPVGSYQ RDSFKAGGSA SAMLQPLLDN QVGFKNMQNV EHVPLSLDRA MRLVKDVFIS AAERDVYTGD ALRICIVTKE GIREETVSLR KD (1-241 aa encoded by BC020807)

Target Information

PSMB1 is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Quantitative reactive cysteinome profiling reveals a functional link between ferroptosis and proteasome-mediated degradation.

Cell death and differentiation

Wang Y,Wang C

Sun Jan 01 00:00:00 UTC 2023

Molecular alteration of the proteasome contributes to AD-like pathology in the brain of HFD-STZ diabetic rats.

Metabolic brain disease

Gao H,Zhou Y,Jin PS,Wu DG,Wang YN,Zhao X,Zhao B

Wed Mar 01 00:00:00 UTC 2023

Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma.

Cancer letters

Luo H,Feng Y,Wang F,Lin Z,Huang J,Li Q,Wang X,Liu X,Zhai X,Gao Q,Li L,Zhang Y,Wen J,Zhang L,Niu T,Zheng Y

Sat Jul 01 00:00:00 UTC 2023

An ankylosing spondylitis risk variant alters osteoclast differentiation.

Rheumatology (Oxford, England)

Wu F,Han X,Liu J,Zhang Z,Yan K,Wang B,Yang L,Zou H,Yang C,Huang W,Jin L,Wang J,Qian F,Niu Z

Tue May 02 00:00:00 UTC 2023

Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized Protein Overload in the Diabetic Rat Brain.

Cellular and molecular neurobiology

Wu DG,Wang YN,Zhou Y,Gao H,Zhao B

Tue Aug 01 00:00:00 UTC 2023

Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins.

The EMBO journal

Tian G,Hu C,Yun Y,Yang W,Dubiel W,Cheng Y,Wolf DA

Thu Jul 01 00:00:00 UTC 2021

Selective Inhibition of the Immunoproteasome β5i Prevents PTEN Degradation and Attenuates Cardiac Hypertrophy.

Frontiers in pharmacology

Xie X,Wang HX,Li N,Deng YW,Bi HL,Zhang YL,Xia YL,Li HH

Mon Sep 28 00:00:00 UTC 2020

PSMB1 Negatively Regulates the Innate Antiviral Immunity by Facilitating Degradation of IKK-ε.

Viruses

Wu F,Niu Z,Zhou B,Li P,Qian F

Thu Jan 24 00:00:00 UTC 2019

Quercetin Prevents In Vivo and In Vitro Myocardial Hypertrophy Through the Proteasome-GSK-3 Pathway.

Cardiovascular drugs and therapy

Chen K,Rekep M,Wei W,Wu Q,Xue Q,Li S,Tian J,Yi Q,Zhang G,Zhang G,Xiao Q,Luo J,Liu Y

Thu Feb 01 00:00:00 UTC 2018

Quercetin Prevents In Vivo and In Vitro Myocardial Hypertrophy Through the Proteasome-GSK-3 Pathway.

Cardiovascular drugs and therapy

Chen K,Rekep M,Wei W,Wu Q,Xue Q,Li S,Tian J,Yi Q,Zhang G,Zhang G,Xiao Q,Luo J,Liu Y

Thu Feb 01 00:00:00 UTC 2018

Fibrosis, adipogenesis, and muscle atrophy in congenital muscular torticollis.

Medicine

Chen HX,Tang SP,Gao FT,Xu JL,Jiang XP,Cao J,Fu GB,Sun K,Liu SZ,Shi W

Sat Nov 01 00:00:00 UTC 2014

Fibrosis, adipogenesis, and muscle atrophy in congenital muscular torticollis.

Medicine

Chen HX,Tang SP,Gao FT,Xu JL,Jiang XP,Cao J,Fu GB,Sun K,Liu SZ,Shi W

Sat Nov 01 00:00:00 UTC 2014

Proteomic analysis reveals that proteasome subunit beta 6 is involved in hypoxia-induced pulmonary vascular remodeling in rats.

PloS one

Wang J,Xu L,Yun X,Yang K,Liao D,Tian L,Jiang H,Lu W

Fri Feb 07 00:00:00 UTC 2014

Proteomic analysis reveals that proteasome subunit beta 6 is involved in hypoxia-induced pulmonary vascular remodeling in rats.

PloS one

Wang J,Xu L,Yun X,Yang K,Liao D,Tian L,Jiang H,Lu W

Fri Feb 07 00:00:00 UTC 2014

Novel breast cancer metastasis-associated proteins.

Journal of proteome research

Ho J,Kong JW,Choong LY,Loh MC,Toy W,Chong PK,Wong CH,Wong CY,Shah N,Lim YP

Sun Feb 01 00:00:00 UTC 2009

Novel breast cancer metastasis-associated proteins.

Journal of proteome research

Ho J,Kong JW,Choong LY,Loh MC,Toy W,Chong PK,Wong CH,Wong CY,Shah N,Lim YP

Sun Feb 01 00:00:00 UTC 2009

Novel breast cancer metastasis-associated proteins.

Journal of proteome research

Ho J,Kong JW,Choong LY,Loh MC,Toy W,Chong PK,Wong CH,Wong CY,Shah N,Lim YP

Sun Feb 01 00:00:00 UTC 2009

Novel breast cancer metastasis-associated proteins.

Journal of proteome research

Ho J,Kong JW,Choong LY,Loh MC,Toy W,Chong PK,Wong CH,Wong CY,Shah N,Lim YP

Sun Feb 01 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: beta-6; component C5 of proteasome; Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; proteasome (prosome, macropain) subunit, beta type, 1; proteasome beta 1 subunit; proteasome beta-subunit C5; Proteasome component C5; Proteasome gamma chain; Proteasome subunit beta type-1; Proteasome subunit beta-6; proteasome subunit C5; proteasome subunit HC5; proteasome subunit RC5; testicular secretory protein Li 45

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Gene Aliases: AA409053; C81484; HC5; Lmpc5; PMSB1; PSC5; PSMB1

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UniProt ID: (Human) P20618, (Mouse) O09061, (Rat) P18421

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Entrez Gene ID: (Human) 5689, (Mouse) 19170, (Rat) 94198

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Function(s)

threonine-type endopeptidase activity protein binding endopeptidase activity peptidase activity hydrolase activity

Process(es)

proteolysis proteasomal ubiquitin-independent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process MAPK cascade protein polyubiquitination stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of cellular amino acid metabolic process viral process anaphase-promoting complex-dependent catabolic process tumor necrosis factor-mediated signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway regulation of mRNA stability T cell receptor signaling pathway negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition Wnt signaling pathway, planar cell polarity pathway negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PSMB1 Polyclonal Antibody

PSMB1 Antibody (11749-1-AP) in ICC/IF

Product Details

11749-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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