Proteintech

PSMB5 Polyclonal Antibody

PSMB5 Antibody in Immunocytochemistry (ICC/IF)

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PSMB5 Antibody (19178-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using (Product # 19178-1-AP) (PSMB5 antibody), at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PSMB5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

19178-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PSMB5 Fusion Protein Ag5828 (1-263 aa encoded by BC057840)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MALASVLER PLPVNQRGFF GLGGRADLLD LGPGSLSDGL SLAAPGWGVP EEPGIEMLHG TTTLAFKFRH GVIVAADSRA TAGAYIASQT VKKVIEINPY LLGTMAGGAA DCSFWERLLA RQCRIYELRN KERISVAAAS KLLANMVYQY KGMGLSMGTM ICGWDKRGPG LYYVDSEGNR ISGATFSVGS GSVYAYGVMD RGYSYDLEVE QAYDLARRAI YQATYRDAYS GGAVNLYHVR EDGWIRVSSD NVADLHEKYS GSTP (1-263 aa encoded by BC057840)

Target Information

Cyclic nucleotide phosphodiesterases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism.

Free radical biology & medicine

Xiong Q,Sun H,Xing W,Li X,Chen G,Zhao Z,Wu C,Li P

Sat May 20 00:00:00 UTC 2023

Cascade-Activated AIEgen-Peptide Probe for Noninvasively Monitoring Chymotrypsin-like Activity of Proteasomes in Cancer Cells.

Analytical chemistry

Jiao Q,Zheng Y,Pei S,Luo X,Wu X,Xu K,Zhong W

Tue Jun 13 00:00:00 UTC 2023

Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma.

Cancer letters

Luo H,Feng Y,Wang F,Lin Z,Huang J,Li Q,Wang X,Liu X,Zhai X,Gao Q,Li L,Zhang Y,Wen J,Zhang L,Niu T,Zheng Y

Sat Jul 01 00:00:00 UTC 2023

Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma.

Cancer letters

Luo H,Feng Y,Wang F,Lin Z,Huang J,Li Q,Wang X,Liu X,Zhai X,Gao Q,Li L,Zhang Y,Wen J,Zhang L,Niu T,Zheng Y

Sat Jul 01 00:00:00 UTC 2023

Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP).

Biochemical pharmacology

Xie X,Shen TT,Bi HL,Su ZL,Liao ZQ,Zhang Y,Shi L,Xia YL

Mon Aug 01 00:00:00 UTC 2022

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.

Nature communications

Vdovin A,Jelinek T,Zihala D,Sevcikova T,Durech M,Sahinbegovic H,Snaurova R,Radhakrishnan D,Turi M,Chyra Z,Popkova T,Venglar O,Hrdinka M,Hajek R,Simicek M

Thu Nov 10 00:00:00 UTC 2022

Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells.

Journal of Cancer

Yu H,Kim YM,Cho M

Mon Sep 28 00:00:00 UTC 2020

Selective Inhibition of the Immunoproteasome β5i Prevents PTEN Degradation and Attenuates Cardiac Hypertrophy.

Frontiers in pharmacology

Xie X,Wang HX,Li N,Deng YW,Bi HL,Zhang YL,Xia YL,Li HH

Mon Sep 28 00:00:00 UTC 2020

Cancer vulnerabilities unveiled by genomic loss.

Cell

Nijhawan D,Zack TI,Ren Y,Strickland MR,Lamothe R,Schumacher SE,Tsherniak A,Besche HC,Rosenbluh J,Shehata S,Cowley GS,Weir BA,Goldberg AL,Mesirov JP,Root DE,Bhatia SN,Beroukhim R,Hahn WC

Fri Aug 17 00:00:00 UTC 2012

Cancer vulnerabilities unveiled by genomic loss.

Cell

Nijhawan D,Zack TI,Ren Y,Strickland MR,Lamothe R,Schumacher SE,Tsherniak A,Besche HC,Rosenbluh J,Shehata S,Cowley GS,Weir BA,Goldberg AL,Mesirov JP,Root DE,Bhatia SN,Beroukhim R,Hahn WC

Fri Aug 17 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: beta-5; Macropain epsilon chain; MGC118075; Multicatalytic endopeptidase complex epsilon chain; proteasome (prosome, macropain) subunit, beta type, 5; proteasome beta 5 subunit; proteasome catalytic subunit 3; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit beta type-5; Proteasome subunit beta-5; Proteasome subunit MB1; Proteasome subunit X; proteasome subunit, beta type, 5; PSX large multifunctional protease X; testicular tissue protein Li 153

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Gene Aliases: LMPX; MB1; PSMB5; X

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UniProt ID: (Human) P28074

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Entrez Gene ID: (Human) 5693

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Function(s)

threonine-type endopeptidase activity protein binding peptidase activity

Process(es)

MAPK cascade protein polyubiquitination stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent proteolysis regulation of cellular amino acid metabolic process response to oxidative stress viral process anaphase-promoting complex-dependent catabolic process tumor necrosis factor-mediated signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process regulation of mRNA stability T cell receptor signaling pathway negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition Wnt signaling pathway, planar cell polarity pathway negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PSMB5 Polyclonal Antibody

PSMB5 Antibody (19178-1-AP) in ICC/IF

Product Details

19178-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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