Proteintech

PSMC1 Polyclonal Antibody

FIGURE: 1 / 5

PSMC1 Antibody (11196-1-AP) in WB

Mouse brain tissue were subjected to SDS PAGE followed by western blot with 11196-1-AP ( PSMC1 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Product Details

11196-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PSMC1 Fusion Protein Ag1677 (77-440 aa encoded by BC016368)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EFIRNQEQM KPLEEKQEEE RSKVDDLRGT PMSVGTLEEI IDDNRAIVST SVGSEHYVSI LSFVDKDLLE PGCSVLLNHK VHAVIGVLMD DTDPLVTVMK VEKAPQETYA DIGGLDNQIQ EIKESVELPL THPEYYEEMG IKPPKGVILY GPPGTGKTLL AKAVANQTSA TFLRVVGSEL IQKYLGDGPK LVRELFRVAE EHAPSIVFID EIDAIGTKRY DSNSGGEREI QRTMLELLNQ LDGFDSRGDV KVIMATNRIE TLDPALIRPG RIDRKIEFPL PDEKTKKRIF QIHTSRMTLA DDVTLDDLIM AKDDLSGADI KAICTEAGLM ALRERRMKVT NEDFKKSKEN VLYKKQEGTP EGLYL (77-440 aa encoded by B C016368)

Target Information

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.

PloS one

Chadchankar J,Korboukh V,Conway LC,Wobst HJ,Walker CA,Doig P,Jacobsen SJ,Brandon NJ,Moss SJ,Wang Q

Mon Mar 23 00:00:00 UTC 2020

The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S.

Cellular and molecular life sciences : CMLS

Sbardella D,Tundo GR,Coletta A,Marcoux J,Koufogeorgou EI,Ciaccio C,Santoro AM,Milardi D,Grasso G,Cozza P,Bousquet-Dubouch MP,Marini S,Coletta M

Sat Sep 01 00:00:00 UTC 2018

The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S.

Cellular and molecular life sciences : CMLS

Sbardella D,Tundo GR,Coletta A,Marcoux J,Koufogeorgou EI,Ciaccio C,Santoro AM,Milardi D,Grasso G,Cozza P,Bousquet-Dubouch MP,Marini S,Coletta M

Sat Sep 01 00:00:00 UTC 2018

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.

Oncogene

Sparks A,Dayal S,Das J,Robertson P,Menendez S,Saville MK

Thu Sep 18 00:00:00 UTC 2014

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.

Oncogene

Sparks A,Dayal S,Das J,Robertson P,Menendez S,Saville MK

Thu Sep 18 00:00:00 UTC 2014

Adenoviral expression of TDP-43 and FUS genes and shRNAs for protein degradation pathways in rodent motoneurons in vitro and in vivo.

Neuropathology : official journal of the Japanese Society of Neuropathology

Watabe K,Akiyama K,Kawakami E,Ishii T,Endo K,Yanagisawa H,Sango K,Tsukamoto M

Sat Feb 01 00:00:00 UTC 2014

Adenoviral expression of TDP-43 and FUS genes and shRNAs for protein degradation pathways in rodent motoneurons in vitro and in vivo.

Neuropathology : official journal of the Japanese Society of Neuropathology

Watabe K,Akiyama K,Kawakami E,Ishii T,Endo K,Yanagisawa H,Sango K,Tsukamoto M

Sat Feb 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: 26S protease regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; 26S proteasome regulatory subunit 4; MGC24583; MGC8541; P26s4; peptidase (prosome, macropain) 26S subunit, ATPase 1; protease (prosome, macropain) 26S subunit, ATPase 1; proteasome (prosome, macropain) 26S subunit, ATPase, 1; proteasome 26S ATPase subunit 1; Proteasome 26S subunit ATPase 1; proteasome 26S subunit, ATPase, 1; prs4

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Gene Aliases: AI325227; P26S4; p56; PSMC1; rpt2; Rpt2/S4; S4

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UniProt ID: (Human) P62191, (Rat) P62193, (Mouse) P62192

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Entrez Gene ID: (Human) 5700, (Rat) 117263, (Mouse) 19179

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Function(s)

protein binding ATP binding ATPase activity TBP-class protein binding proteasome-activating ATPase activity poly(A) RNA binding nucleotide binding hydrolase activity

Process(es)

biological_process protein catabolic process MAPK cascade protein polyubiquitination stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of cellular amino acid metabolic process ER-associated ubiquitin-dependent protein catabolic process anaphase-promoting complex-dependent catabolic process tumor necrosis factor-mediated signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process regulation of mRNA stability positive regulation of RNA polymerase II transcriptional preinitiation complex assembly T cell receptor signaling pathway negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition Wnt signaling pathway, planar cell polarity pathway negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway negative regulation of neuron death positive regulation of proteasomal protein catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PSMC1 Polyclonal Antibody

PSMC1 Antibody (11196-1-AP) in WB

Product Details

11196-1-AP

Western Blot (WB)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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