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Invitrogen
PSMC6 Recombinant Rabbit Monoclonal Antibody (PSH0-12)
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FIGURE: 1 / 5
PSMC6 Antibody (MA5-50776) in IHC (P)
Immunohistochemistry of PSMC6 in paraffin-embedded human testis tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with PSMC6 recombinant monoclonal antibody (Product # MA5-50776) with a dilution of 1:400 for 1 hour at roo... View More
Product Details
MA5-50776
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH0-12
Immunogen
Recombinant protein within human PSMC6 aa 1-200/389.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3093729
Product Specific Information
Positive control: Hela cell lysate, 293T cell lysate, SH-SY5Y cell lysate, HepG2 cell lysate, PC-12 cell lysate, NIH/3T3 cell lysate, mouse kidney tissue lysate, rat kidney tissue lysate, rat brain tissue lysate, human testis tissue, SH-SY5Y, NIH/3T3, PC-12.
Predicted band size: 44 kDa
Subcellular Location: Cytoplasm, Nucleus.
Target Information
PSMC6 (proteasome (prosome, macropain) 26S subunit, ATPase 6), also known as P44, p42, SUG2, S10B or CADP44, is a regulatory component of the 26S proteasome. More specifically, PSMC6 is one of the six ATPase subunits of the 19S regulator base. It contains a leucine zipper motif and an AAA (ATPase associated with diverse cellular activities) domain and belongs to the AAA ATPase family of chaperone-like ATPases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 26S protease regulatory subunit 10B; 26S protease regulatory subunit S10B; 26S proteasome AAA-ATPase subunit RPT4; 26S proteasome regulatory subunit 10B; conserved ATPase domain protein 44; epididymis secretory protein Li 73; proteasome (prosome, macropain) 26S subunit, ATPase, 6; proteasome (prosome, macropain) 26S subunit, ATPase, 6-like; Proteasome 26S subunit ATPase 6; Proteasome subunit p42
Gene Aliases: 2300001E01Rik; AI451058; CADP44; HEL-S-73; p42; P44; PSMC6; SUG2
UniProt ID: (Human) P62333, (Mouse) P62334
Entrez Gene ID: (Human) 5706, (Mouse) 67089, (Rat) 289990
protein catabolic process
ER-associated ubiquitin-dependent protein catabolic process
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
positive regulation of inclusion body assembly
positive regulation of proteasomal protein catabolic process
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
ubiquitin-dependent protein catabolic process
regulation of cellular amino acid metabolic process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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