Proteintech

PSMD11 Polyclonal Antibody

PSMD11 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

PSMD11 Antibody (14786-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells using 14786-1-AP (PSMD11 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

PSMD11 Antibody in Immunoprecipitation (IP)

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Product Details

14786-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PSMD11 Fusion Protein Ag6435 (76-422 aa encoded by BC000437)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: FLNSISKAK AARLVRSLLD LFLDMEAATG QEVELCLECI EWAKSEKRTF LRQALEARLV SLYFDTKRYQ EALHLGSQLL RELKKMDDKA LLVEVQLLES KTYHALSNLP KARAALTSAR TTANAIYCPP KLQATLDMQS GIIHAAEEKD WKTAYSYFYE AFEGYDSIDS PKAITSLKYM LLCKIMLNTP EDVQALVSGK LALRYAGRQT EALKCVAQAS KNRSLADFEK ALTDYRAELR DDPIISTHLA KLYDNLLEQN LIRVIEPFSR VQIEHISSLI KLSKADVERK LSQMILDKKF HGILDQGEGV LIIFDEPPVD KTYEAALETI QNMSKVVDSL YNKAKKLT (76-422 aa encoded by BC000437 )

Target Information

The 26S proteasome (PSMD11) is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The protein is a non-ATPase subunit of the 19S regulator.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system.

Nature communications

Saha I,Yuste-Checa P,Da Silva Padilha M,Guo Q,Körner R,Holthusen H,Trinkaus VA,Dudanova I,Fernández-Busnadiego R,Baumeister W,Sanders DW,Gautam S,Diamond MI,Hartl FU,Hipp MS

Thu Feb 02 00:00:00 UTC 2023

Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome.

Journal of medicinal chemistry

Dai Z,An LY,Chen XY,Yang F,Zhao N,Li CC,Ren R,Li BY,Tao WY,Li P,Jiang C,Yan F,Jiang ZY,You QD,Di B,Xu LL

Thu Mar 24 00:00:00 UTC 2022

Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.

BMC developmental biology

Zhao L,Zhao J,Zhang Y,Wang L,Zuo L,Niu A,Zhang W,Xue X,Zhao S,Sun C,Li K,Wang J,Bian Z,Zhao X,Saur D,Seidler B,Wang C,Qi T

Mon Feb 01 00:00:00 UTC 2021

Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.

BMC developmental biology

Zhao L,Zhao J,Zhang Y,Wang L,Zuo L,Niu A,Zhang W,Xue X,Zhao S,Sun C,Li K,Wang J,Bian Z,Zhao X,Saur D,Seidler B,Wang C,Qi T

Mon Feb 01 00:00:00 UTC 2021

Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kesireddy VS,Chillappagari S,Ahuja S,Knudsen L,Henneke I,Graumann J,Meiners S,Ochs M,Ruppert C,Korfei M,Seeger W,Mahavadi P

Fri Nov 01 00:00:00 UTC 2019

Homoharringtonine could induce quick protein synthesis of PSMD11 through activating MEK1/ERK1/2 signaling pathway in pancreatic cancer cells.

Journal of cellular biochemistry

Wang L,Zhao L,Wei G,Saur D,Seidler B,Wang J,Wang C,Qi T

Wed Aug 01 00:00:00 UTC 2018

Homoharringtonine could induce quick protein synthesis of PSMD11 through activating MEK1/ERK1/2 signaling pathway in pancreatic cancer cells.

Journal of cellular biochemistry

Wang L,Zhao L,Wei G,Saur D,Seidler B,Wang J,Wang C,Qi T

Wed Aug 01 00:00:00 UTC 2018

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.

Oncogene

Sparks A,Dayal S,Das J,Robertson P,Menendez S,Saville MK

Thu Sep 18 00:00:00 UTC 2014

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.

Oncogene

Sparks A,Dayal S,Das J,Robertson P,Menendez S,Saville MK

Thu Sep 18 00:00:00 UTC 2014

Proteomic profiling identified multiple short-lived members of the central proteome as the direct targets of the addicted oncogenes in cancer cells.

Molecular & cellular proteomics : MCP

Qi T,Zhang W,Luan Y,Kong F,Xu D,Cheng G,Wang Y

Wed Jan 01 00:00:00 UTC 2014

Proteomic profiling identified multiple short-lived members of the central proteome as the direct targets of the addicted oncogenes in cancer cells.

Molecular & cellular proteomics : MCP

Qi T,Zhang W,Luan Y,Kong F,Xu D,Cheng G,Wang Y

Wed Jan 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: 26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit 9; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

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Gene Aliases: 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik; C78232; P44.5; PSMD11; Rpn6; S9

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UniProt ID: (Human) O00231, (Mouse) Q8BG32

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Entrez Gene ID: (Human) 5717, (Rat) 303353, (Mouse) 69077

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Function(s)

protein binding

Process(es)

ubiquitin-dependent protein catabolic process proteasome assembly stem cell differentiation MAPK cascade protein polyubiquitination stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of cellular amino acid metabolic process anaphase-promoting complex-dependent catabolic process tumor necrosis factor-mediated signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process regulation of mRNA stability T cell receptor signaling pathway negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition Wnt signaling pathway, planar cell polarity pathway negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PSMD11 Polyclonal Antibody

PSMD11 Antibody (14786-1-AP) in ICC/IF

Product Details

14786-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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