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Product Details
CL488-67682
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG3
Class
Monoclonal
Type
Antibody
Clone
1D5F7
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LTQAGLEALF ESNLLDDLKS VMKTNDIVRY RVYELIIEIS SVSPESLNYC TTSGLVTQLL RELTGEDVLV RATCIEMVTS LAYTHHGRQY LAQEGVIDQI SNIIVGADSD PFSSFYLPGF VKFFGNLAVM DSPQQICERY PIFVEKVFEM IESQDPTMIG VAVDTVGILG SNVEGKQVLQ KTGTRFERLL MRIGHQSKNA PVELKIRCLD AISSLLYLPP EQQTDDLLRM TESWFSSLSR DPLELFRGIS SQPFPELHCA ALKVFTAIAN QPWAQKLMFN SPGFVEYVVD RSVEHDKASK DAKYELVKAL ANSKTIAEIF GNPNYLRLRT YLSEGPYYVK PVSTTAVEGA E
Target Information
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator base.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 26S protease subunit S5 basic; 26S proteasome non-ATPase regulatory subunit 5; 26S proteasome subunit S5B; MGC23145; proteasome (prosome, macropain) 26S subunit, non-ATPase, 5; proteasome 26S non-ATPase subunit 5; RP11-27I1.5
Gene Aliases: 1500032A03Rik; AW475925; KIAA0072; mKIAA0072; PSMD5; S5B; W91691
UniProt ID: (Human) Q16401, (Mouse) Q8BJY1
Entrez Gene ID: (Rabbit) 100339098, (Human) 5711, (Mouse) 66998, (Rat) 296651
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
proteasome regulatory particle assembly
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
proteasome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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