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Immunogen sequence: MAATFFGEVV KAPCRAGTED EEEEEEGRRE TPEDREVRLQ LARKREVRLL RRQTKTSLEV SLLEKYPCSK FIIAIGNNAV AFLSSFVMNS GVWEEVGCAK LWNEWCRTTD TTHLSSTEAF CVFYHLKSNP SVFLCQCSCY VAEDQQYQWL EKVFGSCPRK NMQITILTCR HVTDYKTSES TGSLPSPFLR ALKTQNFKDS ACCPLLEQPN IVHDLPAAVL SYCQVWKIPA ILYLCYTDVM KLDLITVEAF KPILSTRSLK GLVKNIPQST EILKKLMTTN EIQSNIYT; Positive Samples: HeLa; Cellular Location: Cytoplasm, Endoplasmic reticulum
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C21-LRP; Chromosome 21 leucine-rich protein; Down syndrome critical region gene 2; Down syndrome critical region homolog 2; Down syndrome critical region protein 2; Down syndrome critical region protein 2 homolog; leucine rich protein C21-LRP; PAC-1; Pba1; proteasome (prosome, macropain) assembly chaperone 1; proteasome assembling chaperone 1; Proteasome assembly chaperone 1; Proteasome chaperone homolog 1; psmg1
Gene Aliases: AW552102; C21LRP; DSCR2; LRPC21; PAC-1; PAC1; PSMG1
UniProt ID: (Human) O95456, (Mouse) Q9JK23
Entrez Gene ID: (Human) 8624, (Mouse) 56088, (Rat) 288236
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