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Product Details
27130-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PSRC1 Fusion Protein Ag26039 (1-215 aa encoded by BC056909)
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEDLEEDVR FIVDETLDFG GLSPSDSREE EDITVLVTPE KPLRRGLSHR SDPNAVAPAP QGVRLSLGPL SPEKLEEILD EANRLAAQLE QCALQDRESA GEGLGPRRVK PSPRRETFVL KDSPVRDLLP TVNSLTRSTP SPSSLTPRLR SNDRKGSVRA LRATSGKRPS NMKRESPTCN LFPASKSPAS SPLTRSTPPV RGRAGPSGRA AASEET (1-215 aa encoded by B C056909)
Target Information
PSRC1 is required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: differential display and activated by p53; MGC1780; OTTHUMP00000013785; OTTHUMP00000013786; p53-regulated DDA3; proline/serine-rich coiled-coil 1; Proline/serine-rich coiled-coil protein 1
Gene Aliases: DDA3; FP3214; PSRC1
UniProt ID: (Human) Q6PGN9
Entrez Gene ID: (Human) 84722
microtubule bundle formation
mitotic metaphase plate congression
negative regulation of cell growth
positive regulation of microtubule polymerization
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription, DNA-templated
cell division
regulation of mitotic spindle organization
Performance Guarantee
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