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Invitrogen
PSRC1 Polyclonal Antibody
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FIGURE: 1 / 5
PSRC1 Antibody (PA5-78606) in ICC/IF
PSRC1 Polyclonal Antibody detects PSRC1 protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: PSRC1 protein stained by PSRC1 Polyclonal Antibody (Product # PA5-78606) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
Product Details
PA5-78606
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PSRC1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.86 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2736472
Product Specific Information
Positive Control: 293T, A431, human PSRC1-transfected 293T
Predicted Reactivity: Rhesus Monkey (95%), Bovine (86%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PSRC1 is required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: differential display and activated by p53; MGC1780; OTTHUMP00000013785; OTTHUMP00000013786; p53-regulated DDA3; proline/serine-rich coiled-coil 1; Proline/serine-rich coiled-coil protein 1
Gene Aliases: 5430413I02Rik; AL033312; DDA3; FP3214; PSRC1
UniProt ID: (Human) Q6PGN9, (Mouse) Q9D0P7
Entrez Gene ID: (Human) 84722, (Mouse) 56742
microtubule bundle formation
cell cycle
mitotic nuclear division
mitotic metaphase plate congression
cellular process
negative regulation of cell growth
positive regulation of microtubule polymerization
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription, DNA-templated
cell division
regulation of mitotic spindle organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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