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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PTBP1 Antibodies

          Proteintech

          PTBP1 Polyclonal Antibody

          46 References
          View all (25) PTBP1 antibodies

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          Datasheet
          Protocols
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          Datasheet
          Protocols
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          Cite PTBP1 Polyclonal Antibody

          • Antibody Testing Data (20)
          PTBP1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          PTBP1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 20

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          PTBP1 Antibody (12582-1-AP) in ICC/IF

          Immunofluorescent analysis of A2780 cells, using PTBP1 antibody 12582-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          PTBP1 Antibody in Immunocytochemistry (ICC/IF)
          PTBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PTBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PTBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PTBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PTBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PTBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PTBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PTBP1 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)
          PTBP1 Antibody in Western Blot (WB)

          Product Details

          12582-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:6,000
          View 30 publications 30 publications

          Immunohistochemistry (IHC)

          -
          View 2 publications 2 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunohistochemistry (PFA fixed) (IHC (PFA))

          1:200
          -

          Immunocytochemistry (ICC/IF)

          1:10-1:100
          View 7 publications 7 publications

          Immunoprecipitation (IP)

          -
          View 1 publication 1 publication

          RNA Immunoprecipitation (RIP)

          -
          View 3 publications 3 publications

          Miscellaneous PubMed (MISC)

          -
          View 1 publication 1 publication

          Not applicable (N/A)

          -
          View 2 publications 2 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          PTBP1 Fusion Protein Ag3277 (1-370 aa encoded by BC013694)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.25 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: MDGIVPDIA VGTKRGSDEL FSTCVTNGPF IMSSNSASAA NGNDSKKFKG DSRSAGVPSR VIHIRKLPID VTEGEVISLG LPFGKVTNLL MLKGKNQAFI EMNTEEAANT MVNYYTSVTP VLRGQPIYIQ FSNHKELKTD SSPNQARAQA ALQAVNSVQS GNLALAASAA AVDAGMAMAG QSPVLRIIVE NLFYPVTLDV LHQIFSKFGT VLKIITFTKN NQFQALLQYA DPVSAQHAKL SLDGQNIYNA CCTLRIDFSK LTSLNVKYNN DKSRDYTRPD LPSGDSQPSL DQTMAAAFGA PGIISASPYA GAGFPPTFAI PQAAGLSVPN VHGALAPLAI PSAAAAAAAA GRIAIPGLAG AGNSVLLVSN L (1-370 aa encoded by BC013694)

          Target Information

          This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: 57 kDa RNA-binding protein PPTB-1; Heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; MGC10830; MGC8461; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); Polypyrimidine tract-binding protein 1; PTB; PYBP; pyrimidine binding protein 1; pyrimidine binding protein 2; Pyrimidine-binding protein; RNA-binding protein

          View more View less

          Gene Aliases: AA407203; AL033359; HNRNP-I; HNRNPI; HNRPI; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; PTBP1; Pybp; Pybp1; Pybp2; Tbfii

          View more View less

          UniProt ID: (Human) P26599, (Mouse) P17225, (Rat) Q00438

          View more View less

          Entrez Gene ID: (Human) 5725, (Mouse) 19205, (Rat) 29497

          View more View less

          Function(s)
          nucleotide binding RNA binding protein binding poly-pyrimidine tract binding pre-mRNA binding poly(A) RNA binding nucleic acid binding single-stranded DNA binding endonuclease activity
          Process(es)
          regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome mRNA processing RNA splicing fibroblast growth factor receptor signaling pathway gene expression negative regulation of RNA splicing negative regulation of mRNA splicing, via spliceosome negative regulation of muscle cell differentiation IRES-dependent viral translational initiation positive regulation of transcription from RNA polymerase II promoter nucleic acid phosphodiester bond hydrolysis
          It has to be done as per old AB suggested Products section.
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