Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Bioss
PTF1A Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
BS-11930R
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PTF1A, amino acids 165-260.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 1% BSA
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PFT1A is a component of the pancreas transcription factor 1 complex and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: bHLH transcription factor p48; bHLHa29; Class A basic helix-loop-helix protein 29; class II bHLH protein PTF1A; exocrine pancreas-specific transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; Pancreas transcription factor 1 subunit alpha; pancreas transcription factor1 p48 subunit; Pancreas-specific transcription factor 1a; PTF1-p48
Gene Aliases: BHLHA29; PACA; PAGEN2; PTF1-p48; PTF1A; PTF1P48
UniProt ID: (Human) Q7RTS3, (Rat) Q64305, (Mouse) Q9QX98
Entrez Gene ID: (Human) 256297, (Rat) 117034, (Mouse) 19213
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
protein dimerization activity
E-box binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
protein binding
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
embryo development
tissue development
retina layer formation
cerebellum development
pancreas development
exocrine pancreas development
amacrine cell differentiation
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
neuron fate commitment
regulation of neural retina development
transcription, DNA-templated
cell differentiation
hindbrain development
cell fate commitment
positive regulation of transcription, DNA-templated
generation of neurons
retina morphogenesis in camera-type eye
multicellular organism development
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support