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Product Details
H00256297-M03
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1B8
Immunogen
PTF1A (NP_835455, 250 a.a. approximately 328 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: QAQKVIICHR GTRSPSPSDP DYGLPPLAGH SLSWTDEKQL KEQNIIRTAK VWTPEDPRKL NSKSSFNNIE NEPPFEFVS
Target Information
PFT1A is a component of the pancreas transcription factor 1 complex and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLH transcription factor p48; bHLHa29; Class A basic helix-loop-helix protein 29; class II bHLH protein PTF1A; exocrine pancreas-specific transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; Pancreas transcription factor 1 subunit alpha; Pancreas-specific transcription factor 1a; PTF1-p48
Gene Aliases: BHLHA29; PACA; PAGEN2; PTF1-p48; PTF1A; PTF1P48
UniProt ID: (Human) Q7RTS3
Entrez Gene ID: (Human) 256297
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
embryo development
tissue development
retina layer formation
cerebellum development
pancreas development
exocrine pancreas development
amacrine cell differentiation
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
neuron fate commitment
regulation of neural retina development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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