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Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Hamster, Bovine, Dog (94%) Mouse, Rat, Bat (81%).
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1 (subtype EP1), 42kD; prostaglandin E receptor 1 (subtype EP1), 42kDa; prostaglandin E receptor 1, subtype EP1; Prostaglandin E2 receptor EP1 subtype; Prostanoid EP1 receptor
Gene Aliases: EP1; PTGER1
UniProt ID: (Human) P34995
Entrez Gene ID: (Human) 5731
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