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Proteintech
PTGER4 Polyclonal Antibody
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Product Details
24895-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTGER4 Fusion Protein Ag19217 (333-488 aa encoded by BC101534)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RKTVLSKAI EKIKCLFCRI GGSRRERSGQ HCSDSQRTSS AMSGHSRSFI SRELKEISST SQTLLPDLSL PDLSENGLGG RNLLPGVPGM GLAQEDTTSL RTLRISETSD SSQGQDSESV LLVDEAGGSG RAGPAPKGSS LQVTFPSETL NLSEKCI (333-488 aa encoded by BC101534 )
Target Information
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EP1; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); Prostaglandin E2 receptor EP4 subtype; prostaglandin E2 receptor type 4; Prostanoid EP4 receptor
Gene Aliases: EP4; EP4R; Ptger; PTGER2; PTGER4; Ptgerep4
UniProt ID: (Human) P35408, (Mouse) P32240, (Rat) P43114
Entrez Gene ID: (Human) 5734, (Mouse) 19219, (Rat) 84023
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
JNK cascade
intestine smooth muscle contraction
positive regulation of smooth muscle cell migration
regulation of ossification
positive regulation of cAMP biosynthetic process
response to lipopolysaccharide
positive regulation of interleukin-8 production
negative regulation of integrin activation
positive regulation of urine volume
positive regulation of renal sodium excretion
T-helper cell differentiation
positive regulation of bone resorption
negative regulation of cytokine secretion
positive regulation of cytokine secretion
negative regulation of inflammatory response
positive regulation of inflammatory response
negative regulation of oxidoreductase activity
regulation of stress fiber assembly
bone development
positive regulation of mucus secretion
ERK1 and ERK2 cascade
ductus arteriosus closure
positive regulation of hyaluronan biosynthetic process
positive regulation of ovarian follicle development
positive regulation of antral ovarian follicle growth
positive regulation of neutrophil extravasation
negative regulation of eosinophil extravasation
negative regulation of peroxidase activity
negative regulation of peptide secretion
immune response
positive regulation of cytosolic calcium ion concentration
female pregnancy
positive regulation of cell proliferation
response to mechanical stimulus
positive regulation of gene expression
negative regulation of hydrogen peroxide metabolic process
regulation of circadian sleep/wake cycle, wakefulness
response to progesterone
negative regulation of circadian sleep/wake cycle, REM sleep
chemokinesis
response to drug
positive regulation of tyrosine phosphorylation of Stat3 protein
response to amino acid
positive regulation of osteoblast differentiation
positive regulation of cell adhesion
positive regulation of circadian sleep/wake cycle, non-REM sleep
negative regulation of interleukin-1 alpha secretion
negative regulation of nitric-oxide synthase biosynthetic process
maternal process involved in parturition
cellular response to mechanical stimulus
cellular response to glucose stimulus
cellular response to interleukin-1
cellular response to prostaglandin E stimulus
positive regulation of wound healing
response to salt
negative regulation of ductus arteriosus closure
negative regulation of small intestine smooth muscle contraction
positive regulation of calcitonin secretion
positive regulation of chemokinesis
positive regulation of matrix metallopeptidase secretion
negative regulation of tumor necrosis factor secretion
negative regulation of endothelin secretion
positive regulation of substance P secretion, neurotransmission
response to water-immersion restraint stress
positive regulation of interleukin-10 secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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