Proteintech

PTGES2 Polyclonal Antibody

PTGES2 Antibody in Immunocytochemistry (ICC/IF)

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PTGES2 Antibody (10881-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 10881-1-AP (PTGES2 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

PTGES2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PTGES2 Antibody in Immunoprecipitation (IP)

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Product Details

10881-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Plant

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PTGES2 Fusion Protein Ag1329 (1-377 aa encoded by BC011613)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDPAARVVR ALWPGGCALA WRLGGRPQPL LPTQSRAGFA GAAGGPSPVA AARKGSPRLL GAAALALGGA LGLYHTARWH LRAQDLHAER SAAQLSLSSR LQLTLYQYKT CPFCSKVRAF LDFHALPYQV VEVNPVRRAE IKFSSYRKVP ILVAQEGESS QQLNDSSVII SALKTYLVSG QPLEEIITYY PAMKAVNEQG KEVTEFGNKY WLMLNEKEAQ QVYGGKEART EEMKWRQWAD DWLVHLISPN VYRTPTEALA SFDYIVREGK FGAVEGAVAK YMGAAAMYLI SKRLKSRHRL QDNVREDLYE AADKWVAAVG KDRPFMGGQK PNLADLAVYG VLRVMEGLDA FDDLMQHTHI QPWYLRVERA ITEASPAH (1-377 aa encoded by BC011613)

Target Information

Prostoglandin E2 (PGE2) is a potent lipid mediator produced by metabolism of arachidonic acid via the cyclooxygenase (COX) pathway. Following cellular stimulation, arachidonic acid is hydrolyzed from phospholipids stores by one of a family of phospholipase A2 enzymes and converted to the unstable endoperoxide PGH2 by either COX 1 or COX 2. PGH2 is isomerized to PGE2 by one of 3 distinct enzymes microsomal PGES 1 (mPGES 1), mPGES 2, or a cytosolic enzyme, cPGES. PGE2 is active in a number of physiological systems and settings including inflammation, immune regulation, generation of fever, pain perception, protection of the gastric muscosa, fertility and parturition, as well as sodium and water retention. The effects of PGE2 are transduced by 4 subtypes of G protein coupled receptors designated EP1, EP2, EP3, EP4, with Kd values for PGE2 ranging from 1 10 nM. PGE2 is rapidly metabolized in vivo by the prostaglandin 15 dehydrogenase pathway (15 hydroxy PGDH) to the inactive metabolite 13,14 dihydro 15 keto PGE2. The half life of PGE2 in the circulatory system is ~30 seconds and normal plasma levels are 3 12 pg/mL

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Elevated β-secretase 1 expression mediates CD4⁺ T cell dysfunction via PGE2 signalling in Alzheimer's disease.

Brain, behavior, and immunity

Dai L,Wang Q,Lv X,Gao F,Chen Z,Shen Y

Mon Nov 01 00:00:00 UTC 2021

Curc-mPEG454, a PEGylated curcumin derivative, as a multi-target anti-fibrotic prodrug.

International immunopharmacology

Xiao S,Deng Y,Shen N,Sun Y,Tang H,Hu P,Ren H,Peng M

Wed Dec 01 00:00:00 UTC 2021

Prostaglandin E₂ increases the expression of cyclooxygenase-2 in cultured rat microglia.

Journal of neuroimmunology

Nagano T,Tsuda N,Fujimura K,Ikezawa Y,Higashi Y,Kimura SH

Wed Dec 15 00:00:00 UTC 2021

Cyclooxygenase-2 is acutely induced by CCAAT/enhancer-binding protein β to produce prostaglandin E ₂ and F _2α following gonadotropin stimulation in Leydig cells.

Molecular reproduction and development

Yazawa T,Imamichi Y,Yuhki KI,Uwada J,Mikami D,Shimada M,Miyamoto K,Kitano T,Takahashi S,Sekiguchi T,Suzuki N,Rafiqul Islam Khan M,Ushikubi F,Umezawa A,Taniguchi T

Mon Jul 01 00:00:00 UTC 2019

Coupling of oxidative stress responses to tricarboxylic acid cycle and prostaglandin E₂ alterations in Caenorhabditis elegans under extremely low-frequency electromagnetic field.

International journal of radiation biology

Sun Y,Shi Z,Wang Y,Tang C,Liao Y,Yang C,Cai P

Sat Dec 01 00:00:00 UTC 2018

Coupling of oxidative stress responses to tricarboxylic acid cycle and prostaglandin E₂ alterations in Caenorhabditis elegans under extremely low-frequency electromagnetic field.

International journal of radiation biology

Sun Y,Shi Z,Wang Y,Tang C,Liao Y,Yang C,Cai P

Sat Dec 01 00:00:00 UTC 2018

Prostaglandin E2 triggers cytochrome P450 17α hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.

Oncology letters

Ke J,Shen Z,Li M,Peng C,Xu P,Wang M,Zhu Y,Zhang X,Wu D

Mon Oct 01 00:00:00 UTC 2018

Prostaglandin E2 triggers cytochrome P450 17α hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.

Oncology letters

Ke J,Shen Z,Li M,Peng C,Xu P,Wang M,Zhu Y,Zhang X,Wu D

Mon Oct 01 00:00:00 UTC 2018

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Ke J,Yang Y,Che Q,Jiang F,Wang H,Chen Z,Zhu M,Tong H,Zhang H,Yan X,Wang X,Wang F,Liu Y,Dai C,Wan X

Thu Sep 01 00:00:00 UTC 2016

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Ke J,Yang Y,Che Q,Jiang F,Wang H,Chen Z,Zhu M,Tong H,Zhang H,Yan X,Wang X,Wang F,Liu Y,Dai C,Wan X

Thu Sep 01 00:00:00 UTC 2016

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Ke J,Yang Y,Che Q,Jiang F,Wang H,Chen Z,Zhu M,Tong H,Zhang H,Yan X,Wang X,Wang F,Liu Y,Dai C,Wan X

Thu Sep 01 00:00:00 UTC 2016

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Ke J,Yang Y,Che Q,Jiang F,Wang H,Chen Z,Zhu M,Tong H,Zhang H,Yan X,Wang X,Wang F,Liu Y,Dai C,Wan X

Thu Sep 01 00:00:00 UTC 2016

Effect of propofol on prostaglandin E2 production and prostaglandin synthase-2 and cyclooxygenase-2 expressions in amniotic membrane cells.

Journal of anesthesia

Kim JD,Ahn BM,Joo BS,Kwon JY,Chung HJ,Yu SB

Mon Dec 01 00:00:00 UTC 2014

Effect of propofol on prostaglandin E2 production and prostaglandin synthase-2 and cyclooxygenase-2 expressions in amniotic membrane cells.

Journal of anesthesia

Kim JD,Ahn BM,Joo BS,Kwon JY,Chung HJ,Yu SB

Mon Dec 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: FLJ14038; gamma-interferon-activated transcriptional element-binding factor 1; GATE-binding factor 1; GBF-1; membrane-associated prostaglandin E synthase 2; Membrane-associated prostaglandin E synthase-2; MGC11289; Microsomal prostaglandin E synthase 2; microsomal prostaglandin E synthase-2; mPGE synthase-2; mPGES-2; Prostaglandin E synthase 2; Prostaglandin-H(2) E-isomerase; RP11-395P17.2

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Gene Aliases: 0610038H10Rik; C79137; C9orf15; GBF-1; GBF1; mPGES-2; Mpges2; PGES2; PTGES2

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UniProt ID: (Human) Q9H7Z7, (Mouse) Q8BWM0

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Entrez Gene ID: (Human) 80142, (Rat) 311865, (Mouse) 96979

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Function(s)

DNA binding protein binding electron carrier activity protein disulfide oxidoreductase activity lyase activity heme binding glutathione binding prostaglandin-E synthase activity isomerase activity

Process(es)

cell redox homeostasis positive regulation of transcription, DNA-templated secretion oxidation-reduction process prostaglandin biosynthetic process lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process prostaglandin metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PTGES2 Polyclonal Antibody

PTGES2 Antibody (10881-1-AP) in ICC/IF

Product Details

10881-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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