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Product Details
MA1-83385
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
BGN/1F8
Immunogen
Synthetic peptide corresponding to amino acids 1-34 of mature PTH conjugated to a a proprietary carrier molecule.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_935016
Product Specific Information
Mouse anti Human parathyroid hormone monoclonal antibody, clone BGN/1F8 recognizes human parathyroid hormone (PTH) also known as Parathyrin.
Target Information
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hypothalamic parathyroid hormone; Parathormone; Parathyrin; Parathyroid hormone; parathyroid hormone 1; prepro-PTH; preproparathyroid hormone; PTH
Gene Aliases: PTH; PTH-(1-84); PTH1; Pthp; Pthr1
UniProt ID: (Human) P01270, (Rat) P04089
Entrez Gene ID: (Human) 5741, (Rat) 24694, (Mouse) 19226
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
Rho protein signal transduction
cell-cell signaling
hormone-mediated apoptotic signaling pathway
positive regulation of signal transduction
response to lead ion
regulation of gene expression
positive regulation of bone mineralization
positive regulation of cAMP biosynthetic process
response to vitamin D
cellular macromolecule biosynthetic process
response to drug
bone resorption
response to ethanol
positive regulation of glycogen biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
cAMP metabolic process
positive regulation of glucose import
response to cadmium ion
homeostasis of number of cells within a tissue
response to parathyroid hormone
response to fibroblast growth factor
positive regulation of cell proliferation in bone marrow
negative regulation of apoptotic process in bone marrow
positive regulation of osteoclast proliferation
ossification
transcription from RNA polymerase II promoter
response to nutrient levels
positive regulation of ossification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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