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          • Primary Antibodies ›
          • PYK2 Antibodies

          Abnova

          PTK2B Monoclonal Antibody (3G14)

          View all (39) PYK2 antibodies

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          Cite PTK2B Monoclonal Antibody (3G14)

          • Antibody Testing Data (2)
          PTK2B Antibody in ELISA (ELISA)
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          PTK2B Antibody in ELISA (ELISA)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          PTK2B Antibody (H00002185-M04) in ELISA

          Detection limit for recombinant GST tagged PTK2B is 0.03 ng/mL as a capture antibody. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          PTK2B Antibody in ELISA (ELISA)
          PTK2B Antibody in ELISA (ELISA)

          Product Details

          H00002185-M04

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1-5 µg/mL
          -

          ELISA (ELISA)

          1 ng/mL
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG2a, kappa

          Class

          Monoclonal

          Type

          Antibody

          Clone

          3G14

          Immunogen

          PTK2B (AAH36651, 682 a.a. approximately 871 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          See Label

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4

          Contains

          no preservative

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Product Specific Information

          Sequence of this protein is as follows: VYQMEKDIAM EQERNARYRT PKILEPTAFQ EPPPKPSRPK YRPPPQTNLL APKLQFQVPE GLCASSPTLT SPMEYPSPVN SLHTPPLHRH NVFKRHSMRE EDFIQPSSRE EAQQLWEAEK VKMRQILDKQ QKQMVEDYQW LRQEEKSLDP MVYMNDKSPL TPEKEVGYLE FTGPPQKPPR LGAQSIQPTA

          Target Information

          PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: CADTK; CAK-beta; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; FADK; FADK 2; FAK; FAK1; Focal adhesion kinase 2; FRNK; pp125FAK; Proline-rich tyrosine kinase 2; protein kinase B; Protein-tyrosine kinase 2-beta; PTK2B protein tyrosine kinase 2 beta; RAFTK; Related adhesion focal tyrosine kinase

          View more View less

          Gene Aliases: CADTK; CAKB; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK

          View more View less

          UniProt ID: (Human) Q14289

          View more View less

          Entrez Gene ID: (Human) 2185

          View more View less

          Function(s)
          calmodulin-dependent protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer activity NMDA glutamate receptor activity receptor binding protein binding ATP binding protein complex binding 3-phosphoinositide-dependent protein kinase binding
          Process(es)
          MAPK cascade angiogenesis oocyte maturation response to hypoxia positive regulation of cell-matrix adhesion sprouting angiogenesis adaptive immune response marginal zone B cell differentiation protein complex assembly protein phosphorylation apoptotic process response to stress cellular defense response response to osmotic stress signal transduction cell surface receptor signaling pathway signal complex assembly epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape response to mechanical stimulus response to hormone response to glucose response to lithium ion positive regulation of endothelial cell migration negative regulation of muscle cell apoptotic process regulation of cGMP-mediated signaling regulation of macrophage chemotaxis positive regulation of neuron projection development glial cell proliferation peptidyl-tyrosine phosphorylation regulation of cell adhesion positive regulation of cell growth positive regulation of cell migration negative regulation of bone mineralization regulation of cGMP biosynthetic process positive regulation of actin filament polymerization neuron projection development regulation of inositol trisphosphate biosynthetic process tumor necrosis factor-mediated signaling pathway ionotropic glutamate receptor signaling pathway response to immobilization stress peptidyl-tyrosine autophosphorylation response to cocaine response to drug response to hydrogen peroxide activation of Janus kinase activity negative regulation of apoptotic process stress fiber assembly negative regulation of potassium ion transport positive regulation of JUN kinase activity negative regulation of neuron apoptotic process blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity innate immune response positive regulation of nitric oxide biosynthetic process bone resorption response to ethanol negative regulation of myeloid cell differentiation positive regulation of translation positive regulation of angiogenesis positive regulation of protein kinase activity positive regulation of JNK cascade protein autophosphorylation vascular endothelial growth factor receptor signaling pathway focal adhesion assembly positive regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling positive regulation of nitric-oxide synthase activity regulation of release of sequestered calcium ion into cytosol response to cAMP response to calcium ion positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation long term synaptic depression chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to fluid shear stress activation of GTPase activity regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of establishment of cell polarity regulation of actin cytoskeleton reorganization regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of B cell chemotaxis positive regulation of DNA biosynthetic process
          It has to be done as per old AB suggested Products section.
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