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Invitrogen
PTK7 Polyclonal Antibody
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Product Details
PA5-20425
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide from near the amino terminus of human PTK7.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11154564
Product Specific Information
A suggested positive control is human colon tissue lysate.
PA5-20425 can be used with blocking peptide PEP-0542.
Target Information
CCK4 may function as a cell adhesion molecule. Although it belongs to the insulin receptor subfamily of the Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, but weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. It is also expressed in erythroleukemia cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCK-4; Colon carcinoma kinase 4; Inactive tyrosine-protein kinase 7; Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK7 protein tyrosine kinase 7; receptor tyrosine kinase-like protein; serum response factor; Tyrosine-protein kinase-like 7
Gene Aliases: 8430404F20Rik; CCK-4; CCK4; chz; mPTK7/CCK4; PTK7; Srf
UniProt ID: (Human) Q13308, (Mouse) Q8BKG3
Entrez Gene ID: (Human) 5754, (Rat) 301242, (Mouse) 71461
protein kinase activity
protein binding
ATP binding
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity, transferring phosphorus-containing groups
establishment of planar polarity
neural tube closure
axis elongation
protein phosphorylation
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine phosphorylation
actin cytoskeleton reorganization
wound healing
establishment of epithelial cell apical/basal polarity
convergent extension
canonical Wnt signaling pathway
lung-associated mesenchyme development
cellular response to retinoic acid
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
cell adhesion
Wnt signaling pathway
ventricular septum development
signal transduction
coronary vasculature development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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