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Invitrogen
PTPN3 Polyclonal Antibody
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PTPN3 Antibody (PA5-15527) in IHC (P)
Immunohistochemistry analysis of PTPN3 in formalin-fixed and paraffin-embedded Human colon carcinoma tissue. Samples were incubated with PTPN3 polyclonal antibody (Product # PA5-15527) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-15527
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 366-397 amino acids from the central region of human PTPH1
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2173530
Target Information
Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation - it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytoskeletal-associated protein tyrosine phosphatase; Protein-tyrosine phosphatase H1; PTP-H1; Tyrosine-protein phosphatase non-receptor type 3
Gene Aliases: 9530011I20Rik; PTP-H1; PTPCL; PTPH1; PTPN3
UniProt ID: (Human) P26045, (Mouse) A2ALK8
Entrez Gene ID: (Human) 5774, (Mouse) 545622
protein dephosphorylation
peptidyl-tyrosine dephosphorylation
negative regulation of mitotic cell cycle
negative regulation of membrane protein ectodomain proteolysis
liver regeneration
regulation of membrane depolarization during action potential
regulation of sodium ion transmembrane transporter activity
dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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