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Invitrogen
PTPRA Polyclonal Antibody
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Product Details
PA5-34136
Product Specifications
Species Reactivity
Bat,
Bovine,
Dog,
Chicken,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat,
Xenopus,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from cytoplasmic domain of human PTPRA.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551489
Target Information
Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation - it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hptp alpha; LCA-related phosphatase; Leukocyte common antigen-related peptide (protein tyrosine phosphate); protein tyrosine phosphatase alpha; protein tyrosine phosphatase receptor type alpha; protein tyrosine phosphatase, receptor type, A; protein tyrosine phosphatase, receptor type, alpha polypeptide; Protein-tyrosine phosphatase alpha; protein-tyrosine-phosphatase alpha; PTP alpha; PTPase-alpha; PTPLCA-related phosphatase; PTPTY-28; R-PTP-alpha; Receptor-type tyrosine-protein phosphatase alpha; RPTP alpha; tyrosine phosphatase alpha
Gene Aliases: BOS_13147; HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA; Ptpalpha; PTPRA; PTPRL2; R-PTP-alpha; RPTP[a]; RPTPA; Rptpalpha; Rptra; Rptralpha
UniProt ID: (Human) P18433, (Mouse) P18052
protein dephosphorylation
dephosphorylation
regulation of protein kinase activity
convergent extension involved in gastrulation
retina development in camera-type eye
MAPK cascade
axon guidance
insulin receptor signaling pathway
peptidyl-tyrosine dephosphorylation
positive regulation of GTPase activity
protein phosphorylation
positive regulation of oligodendrocyte differentiation
oligodendrocyte differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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