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Invitrogen
PTPRB Polyclonal Antibody
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FIGURE: 1 / 3
PTPRB Antibody (PA5-104088) in IHC (P)
Immunohistochemistry analysis of PTPRB in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PTPRB polyclonal antibody (Product # PA5-104088) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-104088
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTPRB(Accession P23467), corresponding to amino acid residues S302-R352.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2853416
Product Specific Information
Antibody detects endogenous levels of total PTPRB.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein tyrosine phosphatase, receptor type, B; protein tyrosine phosphatase, receptor type, beta polypeptide; Protein-tyrosine phosphatase beta; R-PTP-beta; Receptor-type tyrosine-protein phosphatase beta; Vascular endothelial protein tyrosine phosphatase; VE-PTP
Gene Aliases: 3230402H02Rik; C130094E24; HPTP-BETA; HPTPB; PTPB; PTPRB; Ptpz; R-PTP-BETA; Rptpb; VE-PTP; VEPTP
UniProt ID: (Human) P23467, (Mouse) B2RU80
Entrez Gene ID: (Human) 5787, (Mouse) 19263, (Rat) 314843
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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