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Invitrogen
PTPRG Polyclonal Antibody
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Product Details
PA5-15524
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 751-782 amino acids from the central region of human PTP gamma
Conjugate
Form
Liquid
Concentration
1.7 mg/mL
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2300580
Target Information
RPTP gamma, also known as Receptor-type tyrosine-protein phosphatase gamma, R-PTP-gamma or PTPRG is a protein tyrosine phosphatase (PTP) is a candidate tumor suppressor gene since it is located on human chromosome 3p14.2-p21, a region frequently deleted in certain types of renal and lung carcinomas. In situ hybridization analysis reveals that RPTP gamma mRNA is expressed in specific regions of the brain and that the localization of RPTP gamma changes during brain development. RPTP gamma is composed of a putative extracellular domain, a single transmembrane domain, and a cytoplasmic portion with two tandem catalytic tyrosine phosphatase domains. The extracellular domain contains a stretch of 266 amino acids with striking homology to the zinc-containing enzyme carbonic anhydrase (CAH), indicating that RPTP gamma and RPTP beta (HPTP zeta) represent a subfamily of receptor tyrosine phosphatases. RPTP gamma may have a function other than catalysis of hydration of metabolic CO2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: H_RG317H01.1; protein tyrosine phosphatase gamma; protein tyrosine phosphatase, receptor type, G; protein tyrosine phosphatase, receptor type, gamma polypeptide; Protein-tyrosine phosphatase gamma; Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma); R-PTP-gamma; receptor type protein tyrosine phosphatase gamma; receptor tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; Receptor-type tyrosine-protein phosphatase gamma
Gene Aliases: 5430405N12Rik; AW046354; AW549872; HPTPG; PTPG; PTPRG; R-PTP-GAMMA; RPTPG; RPTPgamma
UniProt ID: (Human) P23470, (Mouse) Q05909
Entrez Gene ID: (Human) 5793, (Mouse) 19270
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of epithelial cell migration
peptidyl-tyrosine dephosphorylation
regulation of homophilic cell adhesion
protein dephosphorylation
negative regulation of neuron projection development
dephosphorylation
toxin transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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