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Invitrogen
PTPRU Monoclonal Antibody (1A6E5)
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Product Details
MA5-31875
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A6E5
Immunogen
Purified recombinant fragment of human PTPRU (AA: extra 579-749) expressed in E. coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2787498
Product Specific Information
MA5-31875 has been tested in indirect ELISA.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLEPP1; Pancreatic carcinoma phosphatase 2; PCP-2; pi R-PTP-Psi; protein tyrosine phosphatase, receptor type, U; Protein-tyrosine phosphatase J; Protein-tyrosine phosphatase pi; Protein-tyrosine phosphatase receptor omicron; PTP pi; PTP-J; PTP-RO; R-PTP-psi; R-PTP-U; Receptor protein tyrosine phosphatase hPTP-J; Receptor-type protein-tyrosine phosphatase psi; Receptor-type tyrosine-protein phosphatase U
Gene Aliases: FMI; hPTP-J; PCP-2; PCP2; PTP; PTP-J; PTP-PI; PTP-RO; PTPPSI; PTPRO; PTPRU; PTPU2; R-PTP-PSI; R-PTP-U
UniProt ID: (Human) Q92729
Entrez Gene ID: (Human) 10076
protein dephosphorylation
cell adhesion
transmembrane receptor protein tyrosine phosphatase signaling pathway
negative regulation of cell proliferation
single organismal cell-cell adhesion
cell differentiation
negative regulation of cell migration
organ regeneration
homotypic cell-cell adhesion
protein localization to cell surface
peptidyl-tyrosine dephosphorylation
response to glucocorticoid
canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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