Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
PTPRZ Monoclonal Antibody (279245)
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
PTPRZ Antibody (MA5-23980) in IHC (P)
Immunohistochemical analysis of PTPRZ in immersion fixed paraffin-embedded sections of human brain (cortex). Samples were incubated in PTPRZ monoclonal antibody (Product # MA5-23980) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal cell bodie... View More
Product Details
MA5-23980
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
279245
Immunogen
E. coli-derived recombinant human PTP beta/zeta/PTPRZ Gly302-Asn754
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609152
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: protein tyrosine phosphatase, receptor-type, Z polypeptide 1; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; R-PTP-zeta; R-PTP-zeta-2; receptor-type tyrosine phosphatase beta/zeta; Receptor-type tyrosine-protein phosphatase zeta
Gene Aliases: HPTPZ; HPTPzeta; HTPZP2; phosphacan; PTP-ZETA; PTP18; PTPRZ; PTPRZ1; PTPRZ2; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta
UniProt ID: (Human) P23471
Entrez Gene ID: (Human) 5803
hematopoietic progenitor cell differentiation
protein dephosphorylation
axonogenesis
axonal fasciculation
central nervous system development
learning or memory
negative regulation of cell proliferation
visual learning
negative regulation of cell-substrate adhesion
hippocampus development
peptidyl-tyrosine dephosphorylation
positive regulation of fibroblast proliferation
oligodendrocyte differentiation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
regulation of oligodendrocyte progenitor proliferation
positive regulation of dendrite development
positive regulation of Schwann cell migration
positive regulation of neuron death
negative regulation of dendrite development
positive regulation of neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support