Proteintech

PURA Polyclonal Antibody

FIGURE: 1 / 5

PURA Antibody (17733-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 17733-1-AP) (PURA antibody) at dilution of 1:3,000 incubated at room temperature for 1.5 hours.

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Product Details

17733-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PURA Fusion Protein Ag12173 (1-322 aa encoded by BC036087)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MADRDSGSE QGGAALGSGG SLGHPGSGSG SGGGGGGGGG GGGSGGGGGG APGGLQHETQ ELASKRVDIR NKRFYLDVKQ NAKGRFLKIA EVGAGGNKSR LTLSMSVAVE FRDYLGDFIE HYAQLGPSQP PDLAQAQDEP RRALKSEFLV RENRKYYMDL KENQRGRFLR IRQTVNRGPG LGSTQGQTIA LPAQGLIEFR DALAKLIDDY GVEEEPAELP EGTSLTVDNK RFFFDVGSNK YGVFMRVSEV KPTYRNSITV PYKVWAKFGH TFCKYSEEMK KIQEKQREKR AACEQLHQQQ QQQQEETAAA TLLLQGEEEG EED (1-322 aa encoded by BC036087)

Target Information

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis.

EBioMedicine

Xu WW,Liao L,Dai W,Zheng CC,Tan XP,He Y,Zhang QH,Huang ZH,Chen WY,Qin YR,Chen KS,He ML,Law S,Lung ML,He QY,Li B

Thu Jun 01 00:00:00 UTC 2023

Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis.

EBioMedicine

Xu WW,Liao L,Dai W,Zheng CC,Tan XP,He Y,Zhang QH,Huang ZH,Chen WY,Qin YR,Chen KS,He ML,Law S,Lung ML,He QY,Li B

Thu Jun 01 00:00:00 UTC 2023

Corrigendum to article "Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation''.

Nucleic acids research

Chen R,Liu Y,Zhuang H,Yang B,Hei K,Xiao M,Hou C,Gao H,Zhang X,Jia C,Li L,Li Y,Zhang N

Mon Apr 19 00:00:00 UTC 2021

Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.

Acta histochemica

Wang Y,Liu Y,Li Y,Liu B,Wu P,Xu S,Shi H

Tue Jan 01 00:00:00 UTC 2019

Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.

Acta histochemica

Wang Y,Liu Y,Li Y,Liu B,Wu P,Xu S,Shi H

Tue Jan 01 00:00:00 UTC 2019

YAP and TAZ Regulate Cc2d1b and Purβ in Schwann Cells.

Frontiers in molecular neuroscience

Sophie B,Jacob H,Jordan VJS,Yungki P,Laura FM,Yannick P

Thu Oct 01 00:00:00 UTC 2020

Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.

Nucleic acids research

Chen R,Liu Y,Zhuang H,Yang B,Hei K,Xiao M,Hou C,Gao H,Zhang X,Jia C,Li L,Li Y,Zhang N

Fri Sep 29 00:00:00 UTC 2017

Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.

Nucleic acids research

Chen R,Liu Y,Zhuang H,Yang B,Hei K,Xiao M,Hou C,Gao H,Zhang X,Jia C,Li L,Li Y,Zhang N

Fri Sep 29 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Pur alpha; pura {ECO:0000250|UniProtKB:P42669}; purine rich element binding protein A; purine-rich element binding protein A; Purine-rich single-stranded DNA-binding protein alpha; purine-rich single-stranded DNA-binding protein alpha {ECO:0000250|UniProtKB:P42669}; Transcriptional activator protein Pur-alpha; transcriptional activator protein Pur-alpha {ECO:0000250|UniProtKB:P42669}

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Gene Aliases: CAGER-1; MRD31; PUR-ALPHA; PUR1; PURA; PURALPHA; ssCRE-BP

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UniProt ID: (Human) Q00577, (Mouse) P42669

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Entrez Gene ID: (Human) 5813, (Mouse) 19290, (Rat) 307498

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Function(s)

translation repressor activity, nucleic acid binding double-stranded telomeric DNA binding single-stranded DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription factor binding purine-rich negative regulatory element binding poly(A) RNA binding SMAD binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding

Process(es)

DNA unwinding involved in DNA replication DNA replication initiation transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development positive regulation of cell proliferation negative regulation of translation cell differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process mitotic cell cycle checkpoint cell proliferation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PURA Polyclonal Antibody

PURA Antibody (17733-1-AP) in WB

Product Details

17733-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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