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Product Details
H00005813-M02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1C10
Immunogen
PURA (NP_005850, 183 a.a. approximately 292 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: TQGQTIALPA QGLIEFRDAL AKLIDDYGVE EEPAELPEGT SLTVDNKRFF FDVGSNKYGV FMRVSEVKPT YRNSITVPYK VWAKFGHTFC KYSEETKKIQ EKQREKRAAC
Target Information
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: pura {ECO:0000250|UniProtKB:P42669}; purine rich element binding protein A; purine-rich element binding protein A; Purine-rich single-stranded DNA-binding protein alpha; purine-rich single-stranded DNA-binding protein alpha {ECO:0000250|UniProtKB:P42669}; Transcriptional activator protein Pur-alpha; transcriptional activator protein Pur-alpha {ECO:0000250|UniProtKB:P42669}
Gene Aliases: MRD31; PUR-ALPHA; PUR1; PURA; PURALPHA
UniProt ID: (Human) Q00577
Entrez Gene ID: (Human) 5813, (Rat) 307498
translation repressor activity, nucleic acid binding
double-stranded telomeric DNA binding
single-stranded DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
purine-rich negative regulatory element binding
poly(A) RNA binding
SMAD binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
DNA unwinding involved in DNA replication
DNA replication initiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
positive regulation of cell proliferation
negative regulation of translation
cell differentiation
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
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