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Proteintech
PURA Monoclonal Antibody (1C6G4), CoraLite® Plus 488
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FIGURE: 1 / 1
PURA Antibody (CL488-67305) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human PURA (CL488-67305, Clone:1C6G4) (red), or 0.4 µg Mouse IgG2a Isotype Control (CL488-66360-2, Clone: K11A1B2A2) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-67305
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1C6G4
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MADRDSGSEQ GGAALGSGGS LGHPGSGSGS GGGGGGGGGG GGSGGGGGGA PGGLQHETQE LASKRVDIRN KRFYLDVKQN AKGRFLKIAE VGAGGNKSRL TLSMSVAVEF RDYLGDFIEH YAQLGPSQPP DLAQAQDEPR RALKSEFLVR ENRKYYMDLK ENQRGRFLRI RQTVNRGPGL GSTQGQTIAL PAQGLIEFRD ALAKLIDDYG VEEEPAELPE GTSLTVDNKR FFFDVGSNKY GVFMRVSEVK PTYRNSITVP YKVWAKFGHT FCKYSEEMKK IQEKQREKRA ACEQLHQQQQ QQQEETAAAT LLLQGEEEGE ED
Target Information
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pur alpha; pura {ECO:0000250|UniProtKB:P42669}; purine rich element binding protein A; purine-rich element binding protein A; Purine-rich single-stranded DNA-binding protein alpha; purine-rich single-stranded DNA-binding protein alpha {ECO:0000250|UniProtKB:P42669}; Transcriptional activator protein Pur-alpha; transcriptional activator protein Pur-alpha {ECO:0000250|UniProtKB:P42669}
Gene Aliases: CAGER-1; MRD31; PUR-ALPHA; PUR1; PURA; PURALPHA; ssCRE-BP
UniProt ID: (Human) Q00577, (Mouse) P42669
Entrez Gene ID: (Human) 5813, (Mouse) 19290, (Rat) 307498
translation repressor activity, nucleic acid binding
double-stranded telomeric DNA binding
single-stranded DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
purine-rich negative regulatory element binding
poly(A) RNA binding
SMAD binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
DNA unwinding involved in DNA replication
DNA replication initiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
positive regulation of cell proliferation
negative regulation of translation
cell differentiation
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
mitotic cell cycle checkpoint
cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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