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Proteintech
PXMP2 Polyclonal Antibody
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Product Details
24801-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PXMP2 Fusion Protein Ag20590 (126-184 aa encoded by BC073997)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FLIMNFLEG KDASAFAAKM RGGFWPALRM NWRVWTPLQF ININYVPLKF RVLFANLAAL (126-184 aa encoded by BC073997)
Target Information
Peroxisomes are subcellular organelles with important functions in lipid metabolism that are found in virtually all eucaryotic cells. The peroxisomal membrane contains a number of integral and peripheral membrane proteins involved in the import of peroxisomal matrix proteins and the transport of metabolites across the membrane. Pxmp2 (Peroxisomal membrane protein 2), also known as PMP22, is a 195 amino acid multi-pass membrane protein that belongs to the peroxisomal membrane protein PXMP2/4 family. The Pxmp2 protein interacts with both Peroxin 19 and Siva proteins. The Peroxin 19 protein binds multiple peroxisomal membrane proteins (PMPs), is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. Pxmp2 is the most abundant peroxisomal membrane protein in higher eukaryotes. Pxmp2's expression is tissue-specific with highest levels of expression in liver, kidney and heart tissue. It has been suggested that Pxmp2 is involved in pore-forming activity and may contribute to the broad permeability of the peroxisomal membrane. Disruption of the mouse Pxmp2 gene leads to partial restriction of peroxisomal membrane permeability to solutes in vitro and in vivo. The Pxmp2 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly and mosquito, and maps to human chromosome 12q24.33.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 22 kDa peroxisomal membrane protein; liver regeneration-related protein LRRG01; Peroxisomal membrane protein 2; peroxisomal membrane protein 2, 22 kDa; peroxisomal membrane protein 2, 22kDa
Gene Aliases: 22kDa; PMP22; PXMP2; T44
UniProt ID: (Human) Q9NR77, (Mouse) P42925, (Rat) Q07066
Entrez Gene ID: (Human) 5827, (Mouse) 19301, (Rat) 29533
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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