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FIGURE: 1 / 5
PXN Antibody (H00005829-D01P) in WB
Western Blot analysis of PXN expression in transfected 293T cell line (H00005829-T03) by PXN MaxPab polyclonal antibody.
Lane 1: PXN transfected lysate(27.70 KDa).
Lane 2: Non-transfected lysate.
Lane 1: PXN transfected lysate(27.70 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00005829-D01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PXN (XP_001132665.1, 1 a.a. approximately 262 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MPDTFNSRSP SVEGSLWAVG TESQGRDWRH LPTITSELSG APRCHTVPCA GSTALQEPGE PQGPPASPSC PEEALAATWE QPWASEVFGP ERMPPSGAAR SFQEVTEPAV VAVDRQAIFP DTWTLTEEHG LQQERPRPEP GRLGSSSPAS VTTEQLGAKM TERGSVARPT QGPETPRSPE GTTEAATQDG KEQPELPCAM AMGTPSTTER ISTSGQAGTS SHGCWAWPLA GLSVGRSSLT ACSLPLCACL LGQKMLRHCG RT
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ16691; hCG_1778014; PAX-1; PAXI; Paxillin; paxillin alpha; testicular tissue protein Li 134
Gene Aliases: PXN
UniProt ID: (Human) P49023
Entrez Gene ID: (Human) 5829
muscle contraction
cell adhesion
cell-matrix adhesion
signal transduction
signal complex assembly
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
cellular response to reactive oxygen species
vascular endothelial growth factor receptor signaling pathway
growth hormone receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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