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Invitrogen
PXR Monoclonal Antibody (1D12G1)
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FIGURE: 1 / 5
PXR Antibody (MA5-31808) in ICC/IF
Immunocytochemistry analysis of PXR in Hela cells (green). Sample was incubated with PXR monoclonal antibody (Product # MA5-31808) using a dilution of 1:200-1:1000 followed by DRAQ5 fluorescent DNA dye (blue), and Alexa Fluor- 555 phalloidin (red labeled actin filaments) .
Product Details
MA5-31808
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1D12G1
Immunogen
Purified recombinant fragment of human NR1I2 (AA: 1-142) expressed in E. coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2787431
Product Specific Information
MA5-31808 has been tested in indirect ELISA.
Target Information
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR 1; PAR 2; PAR q; pregnane X nuclear receptor variant 2; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
Gene Aliases: BXR; NR1I2; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
UniProt ID: (Human) O75469
Entrez Gene ID: (Human) 8856
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
drug binding
zinc ion binding
transcription initiation from RNA polymerase II promoter
xenobiotic metabolic process
signal transduction
steroid metabolic process
intracellular receptor signaling pathway
exogenous drug catabolic process
xenobiotic transport
steroid hormone mediated signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
drug export
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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