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OriGene
PYDC1 Monoclonal Antibody (OTI7A2), TrueMAB™
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FIGURE: 1 / 1
PYDC1 Antibody (CF803612) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PYDC1 (RC211240, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PYDC1. Positive lysates LY407263 (100 µg) and LC407263 (20 µg) can be purchased separately from OriGene.
Product Details
CF803612
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI7A2
Immunogen
Full length human recombinant protein of human PYDC1 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
ASC2 associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. It suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cellular POP1; cPOP1; PAAD-only protein 1; PYD (pyrin domain) containing 1; Pyrin domain-containing protein 1; Pyrin-only protein 1
Gene Aliases: ASC2; ASCI; cPOP1; POP1; PYC1; PYDC1
UniProt ID: (Human) Q8WXC3
Entrez Gene ID: (Human) 260434
activation of innate immune response
positive regulation of defense response to virus by host
myeloid dendritic cell activation involved in immune response
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
negative regulation of protein kinase activity
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
response to bacterium
regulation of autophagy
negative regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of actin filament polymerization
regulation of protein stability
negative regulation of NF-kappaB transcription factor activity
interleukin-1 beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
tumor necrosis factor-mediated signaling pathway
positive regulation of activated T cell proliferation
regulation of GTPase activity
macropinocytosis
innate immune response
negative regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
positive regulation of phagocytosis
positive regulation of ERK1 and ERK2 cascade
positive regulation of chemokine secretion
activation of cysteine-type endopeptidase activity
negative regulation of NLRP3 inflammasome complex assembly
positive regulation of T cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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