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Proteintech
PYGL Monoclonal Antibody (1G12D8)
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Product Details
66769-1-IG
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G12D8
Immunogen
PYGL Fusion Protein Ag8550 (499-846 aa encoded by BC009895)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GLAELIAEK IGEDYVKDLS QLTKLHSFLG DDVFLRELAK VKQENKLKFS QFLETEYKVK INPSSMFDVQ VKRIHEYKRQ LLNCLHVITM YNRIKKDPKK LFVPRTVIIG GKAAPGYHMA KMIIKLITSV ADVVNNDPMV GSKLKVIFLE NYRVSLAEKV IPATDLSEQI STAGTEASGT GNMKFLNGAL TIGTMDGANV EMAEEAGEEN LFIFGMRIDD VAALDKKGYE AKEYYEALPE LKLVIDQIDN GFFSPKQPDL FKDIINMLFY HDRFKVFADY EAYVKCQDKV SQLYMNPKAW NTMVLKNIAA SGKFSSDRTI KEYAQNIWNV EPSDLKISLS NESNKVNGN (499-846 aa encoded by BC009895)
Target Information
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glycogen liver; Glycogen phosphorylase, liver form; GPLL
Gene Aliases: GSD6; PYGL
UniProt ID: (Human) P06737
Entrez Gene ID: (Human) 5836
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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