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Invitrogen
PYROXD1 Polyclonal Antibody
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PYROXD1 Antibody (PA5-114404) in IHC (P)
Immunohistochemistry analysis of PYROXD1 in paraffin-embedded human mammary cancer tissues. Antigen retrieval was performed with citrate buffer (pH6, 20 min). Samples were blocked with 10% goat serum and incubated in PYROXD1 polyclonal antibody (Product # PA5-114404) at a dilution of 1 µg/mL (overnight, 4°C), followed by biotinylated goat anti-rabbit IgG (30 min, 37°C) and Strepavidin-Biotin-Complex (SABC) ... View More
Product Details
PA5-114404
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human PYROXD1 recombinant protein (Position: K48-N230).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2884860
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human placenta tissue, human U-87MG whole cell, human HL-60 whole cell, human THP-1 whole cell, human PC-3 whole cell, rat kidney tissue. IHC: human mammary cancer tissue, human colon cancer tissue, human lung cancer tissue, mouse intestine tissue, rat intestine tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The PYROXD1 gene encodes the protein pyridine nucleotide-disulphide oxidoreductase domain 1, which has a significant role in mitochondrial function and cellular redox homeostasis. This gene is involved in maintaining the balance of oxidative stress within cells and is crucial for the redox regulation of cellular components, impacting processes like energy metabolism and apoptosis. Mutations in PYROXD1 have been associated with early-onset myopathy, indicating its importance in muscle development and maintenance. The protein encoded by PYROXD1 is part of the oxidoreductase enzyme family that facilitates electron transfer, contributing to cellular defense against oxidative damage. Recent studies have linked PYROXD1 to various neuromuscular disorders, where disruptions in its function affect muscle fiber alignment and force production. Understanding its role in redox biology is crucial for developing therapeutic strategies to combat muscle pathologies and redox-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ22028; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
Gene Aliases: PYROXD1
UniProt ID: (Human) Q8WU10, (Rat) Q68FS6, (Mouse) Q3TMV7
Entrez Gene ID: (Human) 79912, (Rat) 297708, (Mouse) 232491
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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